› 3ldi

X-ray diffraction
2.2Å resolution

Crystal structure of aprotinin in complex with sucrose octasulfate: unusual interactions and implication for heparin binding

Released:
DOI: 10.2210/pdb3ldi/pdb
PDB entry 3ldi coloured by chain, front view.
PDB entry 3ldi coloured by chain, side view.
PDB entry 3ldi coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
Crystal structures of aprotinin and its complex with sucrose octasulfate reveal multiple modes of interactions with implications for heparin binding.
Yang IS, Kim TG, Park BS, Cho KJ, Lee JH, Park Y, Kim KH
Biochem Biophys Res Commun 397 429-35 (2010)
PMID: 20529698

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo decamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133761 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Pancreatic trypsin inhibitor Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 58 amino acids
Theoretical weight: 6.53 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P00974 (Residues: 36-93; Coverage: 73%)
Sequence domains: Kunitz/Bovine pancreatic trypsin inhibitor domain
Structure domains: Pancreatic trypsin inhibitor Kunitz domain

Ligands and Environments

3 bound ligands:
Ligand SO4 18 x SO4
Ligand HG 5 x HG
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 4A
Spacegroup: P6322
Unit cell:
a: 119.08Å b: 119.08Å c: 110.794Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.207 0.206 0.234

Quick links

Citations

1 review citation

Recent advances on plasmin inhibitors for the treatment of fibrinolysis-related disorders.
Al-Horani et al. (2014)
3 other articles