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The structure of IL-13 in complex with IL-13Ralpha2

Source organism: Homo sapiens
Biochemical function: cytokine receptor activity
Biological process: immune response
Cellular component: membrane

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GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF09240
Domain description: Interleukin-6 receptor alpha chain, binding
Occurring in:
  1. Interleukin-13 receptor subunit alpha-2
  2. Interleukin-13 receptor subunit alpha-2
The deposited structure of PDB entry 3lb6 contains 1 copy of Pfam domain PF09240 (Interleukin-6 receptor alpha chain, binding) in Interleukin-13 receptor subunit alpha-2. Showing 1 copy in chain B [auth C].
The deposited structure of PDB entry 3lb6 contains 1 copy of Pfam domain PF09240 (Interleukin-6 receptor alpha chain, binding) in Interleukin-13 receptor subunit alpha-2. Showing 1 copy in chain D.

PF03487
Domain description: Interleukin-13
Occurring in:
  1. Interleukin-13
  2. Interleukin-13
The deposited structure of PDB entry 3lb6 contains 1 copy of Pfam domain PF03487 (Interleukin-13) in Interleukin-13. Showing 1 copy in chain A.
The deposited structure of PDB entry 3lb6 contains 1 copy of Pfam domain PF03487 (Interleukin-13) in Interleukin-13. Showing 1 copy in chain C [auth B].

InterPro InterPro annotations
IPR020470
Domain description: Interleukin-13
Occurring in:
  1. Interleukin-13
  2. Interleukin-13
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. Interleukin-13 receptor subunit alpha-2
  2. Interleukin-13 receptor subunit alpha-2
IPR036116
Domain description: Fibronectin type III superfamily
Occurring in:
  1. Interleukin-13 receptor subunit alpha-2
  2. Interleukin-13 receptor subunit alpha-2
IPR003961
Domain description: Fibronectin type III
Occurring in:
  1. Interleukin-13 receptor subunit alpha-2
  2. Interleukin-13 receptor subunit alpha-2
IPR003532
Domain description: Short hematopoietin receptor, family 2, conserved site
Occurring in:
  1. Interleukin-13 receptor subunit alpha-2
  2. Interleukin-13 receptor subunit alpha-2
IPR015321
Domain description: Type I cytokine receptor, cytokine-binding domain
Occurring in:
  1. Interleukin-13 receptor subunit alpha-2
  2. Interleukin-13 receptor subunit alpha-2
IPR018096
Domain description: Interleukin-4/interleukin-13, conserved site
Occurring in:
  1. Interleukin-13
  2. Interleukin-13
IPR009079
Domain description: Four-helical cytokine-like, core
Occurring in:
  1. Interleukin-13
  2. Interleukin-13
IPR001325
Domain description: Interleukin-4/interleukin-13
Occurring in:
  1. Interleukin-13
  2. Interleukin-13

Structure domains

CATH CATH domains
2.60.40.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulins
Occurring in:
  1. Interleukin-13 receptor subunit alpha-2
  2. Interleukin-13 receptor subunit alpha-2
The deposited structure of PDB entry 3lb6 contains 2 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in Interleukin-13 receptor subunit alpha-2. Showing 2 copies in chain B [auth C].
The deposited structure of PDB entry 3lb6 contains 2 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in Interleukin-13 receptor subunit alpha-2. Showing 2 copies in chain D.
1.20.1250.10
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Growth Hormone; Chain: A;
Homology: Growth Hormone; Chain: A;
Occurring in:
  1. Interleukin-13
  2. Interleukin-13
The deposited structure of PDB entry 3lb6 contains 1 copy of CATH domain 1.20.1250.10 (Growth Hormone; Chain: A;) in Interleukin-13. Showing 1 copy in chain A.
The deposited structure of PDB entry 3lb6 contains 1 copy of CATH domain 1.20.1250.10 (Growth Hormone; Chain: A;) in Interleukin-13. Showing 1 copy in chain C [auth B].

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