› 3l9b

X-ray diffraction
1.95Å resolution

Crystal Structure of Rat Otoferlin C2A

Released:
DOI: 10.2210/pdb3l9b/pdb
PDB entry 3l9b coloured by chain, front view.
PDB entry 3l9b coloured by chain, side view.
PDB entry 3l9b coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
The crystal structure of the C₂A domain of otoferlin reveals an unconventional top loop region.
Helfmann S, Neumann P, Tittmann K, Moser T, Ficner R, Reisinger E
J Mol Biol 406 479-90 (2011)
PMID: 21216247

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190173 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Otoferlin Chain: A
Molecule details ›
Chain: A
Length: 144 amino acids
Theoretical weight: 16.41 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9ERC5 (Residues: 1-124; Coverage: 6%)
Gene names: Fer1l2, Otof
Sequence domains: C2 domain
Structure domains: C2 domain

Ligands and Environments

1 bound ligand:
Ligand MG 1 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: I41
Unit cell:
a: 100.3Å b: 100.3Å c: 30Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.345 0.181 0.229
Expression system: Escherichia coli

Quick links

Citations

8 review citations

Auditory neuropathy--neural and synaptic mechanisms.
Moser et al. (2016)
7 more

7 mentions without citation

The Many Faces of DFNB9: Relating OTOF Variants to Hearing Impairment.
Vona et al. (2020)
6 more