PDBe 3l14

X-ray diffraction
1.22Å resolution

Human Carbonic Anhydrase II complexed with Althiazide

Source organism: Homo sapiens
Entry authors: Quirit JG, Robbins A, Genis C, Tu C, Silverman DN, McKenna R

Function and Biology Details

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Carbonic anhydrase 2 Chain: A
Molecule details ›
Chain: A
Length: 260 amino acids
Theoretical weight: 29.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P00918 (Residues: 1-260; Coverage: 100%)
Gene name: CA2
Sequence domains: Eukaryotic-type carbonic anhydrase
Structure domains: Alpha carbonic anhydrase

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: P21
Unit cell:
a: 42.158Å b: 41.396Å c: 72.391Å
α: 90° β: 104.37° γ: 90°
R R work R free
0.13 0.13 0.173
Expression system: Escherichia coli