Protein Data Bank in Europe

Chain: A
Length: 346 amino acids
Theoretical weight: 38.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:

• Canonical: Q9UBE0 (Residues: 1-346; Coverage: 100%)

Gene names: AOS1, SAE1, SUA1, UBLE1A
Pfam: ThiF family
InterPro:

• Ubiquitin-activating enzyme
• ThiF/MoeB/HesA family
• THIF-type NAD/FAD binding fold
• Ubiquitin/SUMO-activating enzyme E1-like

CATH: NAD(P)-binding Rossmann-like Domain

Chain: B
Length: 660 amino acids
Theoretical weight: 73.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:

• Canonical: Q9UBT2 (Residues: 1-640; Coverage: 100%)

Gene names: HRIHFB2115, SAE2, UBA2, UBLE1B
Pfam:

• ThiF family
• Ubiquitin/SUMO-activating enzyme ubiquitin-like domain
• SUMO-activating enzyme subunit 2 C-terminus

InterPro:

• Ubiquitin-activating enzyme
• ThiF/MoeB/HesA family
• THIF-type NAD/FAD binding fold
• 6-pyruvoyl tetrahydropterin synthase/QueD superfamily
• SUMO-activating enzyme subunit Uba2
• Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1
• Ubiquitin activating enzyme, alpha domain superfamily
• Ubiquitin-activating enzyme E1, Cys active site
• Ubiquitin-activating enzyme E1, conserved site
• Ubiquitin/SUMO-activating enzyme ubiquitin-like domain
• SUMO-activating enzyme subunit 2, C-terminal domain

CATH:

• NAD(P)-binding Rossmann-like Domain
• Ubiquitin activating enzymes (Uba3). Chain: B, domain 2
• Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3

Chain: D
Length: 97 amino acids
Theoretical weight: 11.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:

• Canonical: P63165 (Residues: 1-97; Coverage: 96%)

Gene names: OK/SW-cl.43, SMT3C, SMT3H3, SUMO1, UBL1
Pfam: Ubiquitin-2 like Rad60 SUMO-like
InterPro:

• Ubiquitin-like domain superfamily
• Ubiquitin-like domain
• Small ubiquitin-related modifier 1, Ubl domain
• Rad60/SUMO-like domain

CATH: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1