X-ray diffraction
1.6Å resolution

Structure of the N-terminal BRCT domain of human microcephalin (MCPH1).

Source organism: Homo sapiens
Entry authors: Singh N, Heroux A, Thompson JR, Mer G

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Microcephalin Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 103 amino acids
Theoretical weight: 11.64 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q8NEM0 (Residues: 1-101; Coverage: 12%)
Gene name: MCPH1
Sequence domains: twin BRCT domain
Structure domains: BRCT domain

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P21
Unit cell:
a: 35.069Å b: 39.274Å c: 106.639Å
α: 90° β: 91.52° γ: 90°
R R work R free
0.139 0.138 0.195
Expression system: Escherichia coli