3kpz

X-ray diffraction
1.9Å resolution

Crystal structure of a novel vitamin D3 analogue, ZK203278 showing dissociated profile

Released:
Source organism: Homo sapiens
Primary publication:
Crystal structure of a vitamin D3 analog, ZK203278, showing dissociated profile.
Anticancer Res. 32 335-9 (2012)
PMID: 22213324

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Vitamin D3 receptor Chain: A
Molecule details ›
Chain: A
Length: 259 amino acids
Theoretical weight: 29.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P11473 (Residues: 118-427; Coverage: 61%)
Gene names: NR1I1, VDR
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM30A
Spacegroup: P212121
Unit cell:
a: 44.887Å b: 51.892Å c: 132.204Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.228 0.195 0.228
Expression system: Escherichia coli