› › Structure analysis

Mcl-1 in complex with Bim BH3 mutant I2dA

X-ray diffraction
1.945Å resolution
PDB entry 3kj1 coloured by chain, front view.
PDB entry 3kj1 coloured by chain, side view.
PDB entry 3kj1 coloured by chain, top view.
Source organism: Homo sapiens
Assemblies composition:
hetero dimer (preferred)
hetero octamer
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Induced myeloid leukemia cell differentiation protein Mcl-1 and Bcl-2-like protein 11
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Multimeric state: hetero dimer
Accessible surface area: 8800.5 Å2
Buried surface area: 2911.31 Å2
Dissociation area: 1,111.75 Å2
Dissociation energy (ΔGdiss): 24.52 kcal/mol
Dissociation entropy (TΔSdiss): 9.29 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-128964
Assembly 2
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Assembly Name: Induced myeloid leukemia cell differentiation protein Mcl-1 and Bcl-2-like protein 11
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Multimeric state: hetero octamer
Accessible surface area: 31227.83 Å2
Buried surface area: 15370.97 Å2
Dissociation area: 197.88 Å2
Dissociation energy (ΔGdiss): 25.36 kcal/mol
Dissociation entropy (TΔSdiss): -1.64 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-128981

Macromolecules

Induced myeloid leukemia cell differentiation protein Mcl-1
Chain: A
Length: 158 amino acids
Theoretical weight: 17.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q07820 (Residues: 172-327; Coverage: 45%)
Gene names: BCL2L3, MCL1
Pfam: Apoptosis regulator proteins, Bcl-2 family
InterPro:
CATH: Blc2-like
Induced myeloid leukemia cell differentiation protein Mcl-1 in PDB entry 3kj1, assembly 1, front view.
Induced myeloid leukemia cell differentiation protein Mcl-1 in PDB entry 3kj1, assembly 1, side view.
Induced myeloid leukemia cell differentiation protein Mcl-1 in PDB entry 3kj1, assembly 1, top view.
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Bcl-2-like protein 11
Chain: B
Length: 22 amino acids
Theoretical weight: 2.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O43521 (Residues: 143-163; Coverage: 11%)
Gene names: BCL2L11, BIM
Pfam: Bcl-x interacting, BH3 domain
InterPro: Bcl-x interacting, BH3 domain
Bcl-2-like protein 11 in PDB entry 3kj1, assembly 1, front view.
Bcl-2-like protein 11 in PDB entry 3kj1, assembly 1, side view.
Bcl-2-like protein 11 in PDB entry 3kj1, assembly 1, top view.
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