PDBe 3kas

X-ray diffraction
2.4Å resolution

Machupo virus GP1 bound to human transferrin receptor 1


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Transferrin receptor protein 1, serum form Chain: A
Molecule details ›
Chain: A
Length: 640 amino acids
Theoretical weight: 71.81 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
  • Canonical: P02786 (Residues: 121-760; Coverage: 84%)
Gene name: TFRC
Sequence domains:
Structure domains:
Pre-GP-C Chain: B
Molecule details ›
Chain: B
Length: 162 amino acids
Theoretical weight: 18.62 KDa
Source organism: Machupo mammarenavirus
Expression system: Spodoptera frugiperda
  • Canonical: Q8AZ57 (Residues: 83-244; Coverage: 33%)
Gene name: GPC

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: C2221
Unit cell:
a: 143.951Å b: 170.228Å c: 98.471Å
α: 90° β: 90° γ: 90°
R R work R free
0.192 0.189 0.238
Expression systems:
  • Cricetulus griseus
  • Spodoptera frugiperda