› 3k5e

X-ray diffraction
1.97Å resolution

The structure of human kinesin-like motor protein Kif11/KSP/Eg5 in complex with ADP and enastrol.

Released:
DOI: 10.2210/pdb3k5e/pdb
PDB entry 3k5e coloured by chain, front view.
PDB entry 3k5e coloured by chain, side view.
PDB entry 3k5e coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Crawley L, Cheng RKY, Wood M, Barker J, Felicetti B, Whittaker M

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156614 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Kinesin-like protein KIF11 Chains: A, B
Molecule details ›
Chains: A, B
Length: 368 amino acids
Theoretical weight: 41.06 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P52732 (Residues: 1-368; Coverage: 35%)
Gene names: EG5, KIF11, KNSL1, TRIP5
Sequence domains: Kinesin motor domain
Structure domains: Kinesin motor domain

Ligands and Environments

3 bound ligands:
Ligand K5E 2 x K5E
Ligand ADP 2 x ADP
Ligand MG 2 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: C2
Unit cell:
a: 160.58Å b: 79.8Å c: 69.19Å
α: 90° β: 96.93° γ: 90°
R-values:
R R work R free
0.244 0.241 0.295
Expression system: Escherichia coli

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