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Crystal Structure of DcR3-TL1A complex

X-ray diffraction
2.45Å resolution
PDB entry 3k51 coloured by chain, front view.
PDB entry 3k51 coloured by chain, side view.
PDB entry 3k51 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero hexamer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Tumor necrosis factor ligand superfamily member 15, secreted form and Tumor necrosis factor receptor superfamily member 6B
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Multimeric state: hetero hexamer
Accessible surface area: 44357.93 Å2
Buried surface area: 11968.34 Å2
Dissociation area: 3,227.86 Å2
Dissociation energy (ΔGdiss): 4.15 kcal/mol
Dissociation entropy (TΔSdiss): 40.07 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-131829

Macromolecules

Tumor necrosis factor ligand superfamily member 15, secreted form
Chain: A
Length: 184 amino acids
Theoretical weight: 20.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O95150 (Residues: 72-251; Coverage: 72%)
Gene names: TL1, TNFSF15, VEGI
Pfam: TNF(Tumour Necrosis Factor) family
InterPro:
CATH: Jelly Rolls
Tumor necrosis factor ligand superfamily member 15, secreted form in PDB entry 3k51, assembly 1, front view.
Tumor necrosis factor ligand superfamily member 15, secreted form in PDB entry 3k51, assembly 1, side view.
Tumor necrosis factor ligand superfamily member 15, secreted form in PDB entry 3k51, assembly 1, top view.
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Tumor necrosis factor receptor superfamily member 6B
Chain: B
Length: 176 amino acids
Theoretical weight: 19.29 KDa
Source organism: Homo sapiens
Expression system: Drosophila
UniProt:
  • Canonical: O95407 (Residues: 30-195; Coverage: 61%)
Gene names: DCR3, TNFRSF6B, TR6, UNQ186/PRO212
Pfam: TNFR/NGFR cysteine-rich region
InterPro:
CATH: Tumor Necrosis Factor Receptor, subunit A, domain 2
Tumor necrosis factor receptor superfamily member 6B in PDB entry 3k51, assembly 1, front view.
Tumor necrosis factor receptor superfamily member 6B in PDB entry 3k51, assembly 1, side view.
Tumor necrosis factor receptor superfamily member 6B in PDB entry 3k51, assembly 1, top view.
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