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Crystal Structure of Human SIRT6

X-ray diffraction
2Å resolution
PDB entry 3k35 coloured by chain, front view.
PDB entry 3k35 coloured by chain, side view.
PDB entry 3k35 coloured by chain, top view.
Source organism: Homo sapiens
Assemblies composition:
monomeric (preferred)
homo hexamer
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1
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Assembly Name: NAD-dependent protein deacylase sirtuin-6
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Multimeric state: monomeric
Accessible surface area: 13027.01 Å2
Buried surface area: 1724.61 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-185425
Assembly 2
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Assembly Name: NAD-dependent protein deacylase sirtuin-6
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Multimeric state: monomeric
Accessible surface area: 12935.88 Å2
Buried surface area: 1428.51 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-185425
Assembly 3 (preferred)
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Assembly Name: NAD-dependent protein deacylase sirtuin-6
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Multimeric state: monomeric
Accessible surface area: 13004.25 Å2
Buried surface area: 1199.82 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-185425
Assembly 4
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Assembly Name: NAD-dependent protein deacylase sirtuin-6
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Multimeric state: monomeric
Accessible surface area: 13174.01 Å2
Buried surface area: 1447.75 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-185425
Assembly 5
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Assembly Name: NAD-dependent protein deacylase sirtuin-6
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Multimeric state: monomeric
Accessible surface area: 13154.6 Å2
Buried surface area: 1383.45 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-185425
Assembly 6
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Assembly Name: NAD-dependent protein deacylase sirtuin-6
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Multimeric state: monomeric
Accessible surface area: 13281.92 Å2
Buried surface area: 1430.05 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-185425
Assembly 7
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Assembly Name: NAD-dependent protein deacylase sirtuin-6
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Multimeric state: homo hexamer
Accessible surface area: 63772.36 Å2
Buried surface area: 23417.7 Å2
Dissociation area: 3,689.87 Å2
Dissociation energy (ΔGdiss): 27.16 kcal/mol
Dissociation entropy (TΔSdiss): 30.03 kcal/mol
Symmetry number: 6
PDBe Complex ID: PDB-CPX-185428

Macromolecules

NAD-dependent protein deacylase sirtuin-6
Chains: A, B, C, D, E, F
Length: 318 amino acids
Theoretical weight: 35.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8N6T7 (Residues: 3-318; Coverage: 89%)
Gene names: SIR2L6, SIRT6
Pfam: Sir2 family
InterPro:
CATH:
NAD-dependent protein deacylase sirtuin-6 in PDB entry 3k35, assembly 3, front view.
NAD-dependent protein deacylase sirtuin-6 in PDB entry 3k35, assembly 3, side view.
NAD-dependent protein deacylase sirtuin-6 in PDB entry 3k35, assembly 3, top view.
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