Function and Biology Details
Reaction catalysed:
Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate
Biochemical function:
Biological process:
Cellular component:
- not assigned
Sequence domains:
- 3'5'-cyclic nucleotide phosphodiesterase
- HD/PDEase domain
- 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
- Retinal cGMP phosphodiesterase, gamma subunit superfamily
- Retinal cGMP phosphodiesterase, gamma subunit
- 3'5'-cyclic nucleotide phosphodiesterase, conserved site
- 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131206 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'; cGMP-specific 3',5'-cyclic phosphodiesterase
Molecule details ›
Chains: A, B
Length: 330 amino acids
Theoretical weight: 38.28 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: 3'5'-cyclic nucleotide phosphodiesterase
Structure domains: 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Length: 330 amino acids
Theoretical weight: 38.28 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
O76074 (Residues: 535-786, 827-860; Coverage: 33%) - Canonical: P51160 (Residues: 746-785; Coverage: 5%)
Sequence domains: 3'5'-cyclic nucleotide phosphodiesterase
Structure domains: 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
Molecule details ›
Chains: C, D
Length: 18 amino acids
Theoretical weight: 2.19 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
Length: 18 amino acids
Theoretical weight: 2.19 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
- Canonical: P18545 (Residues: 70-87; Coverage: 21%)
