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TRPV1 structures in distinct conformations reveal activation mechanisms.

Cao E, Liao M, Cheng Y, Julius D
Nature 504 113-8 (2013)
Cited: 595 times
EuropePMC logo PMID: 24305161

Abstract

Transient receptor potential (TRP) channels are polymodal signal detectors that respond to a wide range of physical and chemical stimuli. Elucidating how these channels integrate and convert physiological signals into channel opening is essential to understanding how they regulate cell excitability under normal and pathophysiological conditions. Here we exploit pharmacological probes (a peptide toxin and small vanilloid agonists) to determine structures of two activated states of the capsaicin receptor, TRPV1. A domain (consisting of transmembrane segments 1-4) that moves during activation of voltage-gated channels remains stationary in TRPV1, highlighting differences in gating mechanisms for these structurally related channel superfamilies. TRPV1 opening is associated with major structural rearrangements in the outer pore, including the pore helix and selectivity filter, as well as pronounced dilation of a hydrophobic constriction at the lower gate, suggesting a dual gating mechanism. Allosteric coupling between upper and lower gates may account for rich physiological modulation exhibited by TRPV1 and other TRP channels.

Reviews - 3j5q mentioned but not cited (19)

  1. From foe to friend: using animal toxins to investigate ion channel function. Kalia J, Milescu M, Salvatierra J, Wagner J, Klint JK, King GF, Olivera BM, Bosmans F, Bosmans F. J Mol Biol 427 158-175 (2015)
  2. Structure of potassium channels. Kuang Q, Purhonen P, Hebert H. Cell Mol Life Sci 72 3677-3693 (2015)
  3. A structural view of ligand-dependent activation in thermoTRP channels. Steinberg X, Lespay-Rebolledo C, Brauchi S. Front Physiol 5 171 (2014)
  4. Transient Receptor Potential Canonical (TRPC) Channels: Then and Now. Chen X, Sooch G, Demaree IS, White FA, Obukhov AG. Cells 9 E1983 (2020)
  5. Structural insights into the gating mechanisms of TRPV channels. Pumroy RA, Fluck EC, Ahmed T, Moiseenkova-Bell VY. Cell Calcium 87 102168 (2020)
  6. How the TRPA1 receptor transmits painful stimuli: Inner workings revealed by electron cryomicroscopy. Brewster MS, Gaudet R. Bioessays 37 1184-1192 (2015)
  7. Cryo-EM as a powerful tool for drug discovery. Van Drie JH, Tong L. Bioorg Med Chem Lett 30 127524 (2020)
  8. TRP ion channels: Proteins with conformational flexibility. López-Romero AE, Hernández-Araiza I, Torres-Quiroz F, Tovar-Y-Romo LB, Islas LD, Rosenbaum T. Channels (Austin) 13 207-226 (2019)
  9. Current View of Ligand and Lipid Recognition by the Menthol Receptor TRPM8. Yin Y, Lee SY. Trends Biochem Sci 45 806-819 (2020)
  10. Structural Pharmacology of TRP Channels. Zhao Y, McVeigh BM, Moiseenkova-Bell VY. J Mol Biol 433 166914 (2021)
  11. High-resolution views of TRPV1 and their implications for the TRP channel superfamily. Hellmich UA, Gaudet R. Handb Exp Pharmacol 223 991-1004 (2014)
  12. Structural biology of thermoTRPV channels. Yuan P. Cell Calcium 84 102106 (2019)
  13. Electron microscopy holdings of the Protein Data Bank: the impact of the resolution revolution, new validation tools, and implications for the future. Burley SK, Berman HM, Chiu W, Dai W, Flatt JW, Hudson BP, Kaelber JT, Khare SD, Kulczyk AW, Lawson CL, Pintilie GD, Sali A, Vallat B, Westbrook JD, Young JY, Zardecki C. Biophys Rev 14 1281-1301 (2022)
  14. Ligand-Binding Sites in Vanilloid-Subtype TRP Channels. Yelshanskaya MV, Sobolevsky AI. Front Pharmacol 13 900623 (2022)
  15. Centipede Venom: A Potential Source of Ion Channel Modulators. Luo A, Wang A, Kamau PM, Lai R, Luo L. Int J Mol Sci 23 7105 (2022)
  16. Diffracted X-ray Tracking Method for Measuring Intramolecular Dynamics of Membrane Proteins. Fujimura S, Mio K, Ohkubo T, Arai T, Kuramochi M, Sekiguchi H, Sasaki YC. Int J Mol Sci 23 2343 (2022)
  17. TRP (transient receptor potential) ion channel family: structures, biological functions and therapeutic interventions for diseases. Zhang M, Ma Y, Ye X, Zhang N, Pan L, Wang B. Signal Transduct Target Ther 8 261 (2023)
  18. Thermosensory Transient Receptor Potential Ion Channels and Asthma. Kytikova OY, Novgorodtseva TP, Denisenko YK, Naumov DE, Gvozdenko TA, Perelman JM. Biomedicines 9 816 (2021)
  19. Visualizing Intramolecular Dynamics of Membrane Proteins. Ohkubo T, Shiina T, Kawaguchi K, Sasaki D, Inamasu R, Yang Y, Li Z, Taninaka K, Sakaguchi M, Fujimura S, Sekiguchi H, Kuramochi M, Arai T, Tsuda S, Sasaki YC, Mio K. Int J Mol Sci 23 14539 (2022)

Articles - 3j5q mentioned but not cited (52)

  1. TRPV1 structures in distinct conformations reveal activation mechanisms. Cao E, Liao M, Cheng Y, Julius D. Nature 504 113-118 (2013)
  2. TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action. Gao Y, Cao E, Julius D, Cheng Y. Nature 534 347-351 (2016)
  3. Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution. Yan Z, Bai X, Yan C, Wu J, Li Z, Xie T, Peng W, Yin C, Li X, Scheres SHW, Shi Y, Yan N. Nature 517 50-55 (2015)
  4. Cryo-electron microscopy structure of the TRPV2 ion channel. Zubcevic L, Herzik MA, Chung BC, Liu Z, Lander GC, Lee SY. Nat Struct Mol Biol 23 180-186 (2016)
  5. Gating machinery of InsP3R channels revealed by electron cryomicroscopy. Fan G, Baker ML, Wang Z, Baker MR, Sinyagovskiy PA, Chiu W, Ludtke SJ, Serysheva II. Nature 527 336-341 (2015)
  6. Structure of the full-length TRPV2 channel by cryo-EM. Huynh KW, Cohen MR, Jiang J, Samanta A, Lodowski DT, Zhou ZH, Moiseenkova-Bell VY. Nat Commun 7 11130 (2016)
  7. Understanding TRPV1 activation by ligands: Insights from the binding modes of capsaicin and resiniferatoxin. Elokely K, Velisetty P, Delemotte L, Palovcak E, Klein ML, Rohacs T, Carnevale V. Proc Natl Acad Sci U S A 113 E137-45 (2016)
  8. Structural basis of TRPV5 channel inhibition by econazole revealed by cryo-EM. Hughes TET, Lodowski DT, Huynh KW, Yazici A, Del Rosario J, Kapoor A, Basak S, Samanta A, Han X, Chakrapani S, Zhou ZH, Filizola M, Rohacs T, Han S, Moiseenkova-Bell VY. Nat Struct Mol Biol 25 53-60 (2018)
  9. A pain-inducing centipede toxin targets the heat activation machinery of nociceptor TRPV1. Yang S, Yang F, Wei N, Hong J, Li B, Luo L, Rong M, Yarov-Yarovoy V, Zheng J, Wang K, Lai R. Nat Commun 6 8297 (2015)
  10. Electron cryo-microscopy structure of the canonical TRPC4 ion channel. Vinayagam D, Mager T, Apelbaum A, Bothe A, Merino F, Hofnagel O, Gatsogiannis C, Raunser S. Elife 7 e36615 (2018)
  11. Structural insights into the mechanism of activation of the TRPV1 channel by a membrane-bound tarantula toxin. Bae C, Anselmi C, Kalia J, Jara-Oseguera A, Schwieters CD, Krepkiy D, Won Lee C, Kim EH, Kim JI, Faraldo-Gómez JD, Swartz KJ. Elife 5 e11273 (2016)
  12. Capsaicin interaction with TRPV1 channels in a lipid bilayer: molecular dynamics simulation. Hanson SM, Newstead S, Swartz KJ, Sansom MSP. Biophys J 108 1425-1434 (2015)
  13. Molecular determinants of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) binding to transient receptor potential V1 (TRPV1) channels. Poblete H, Oyarzún I, Olivero P, Comer J, Zuñiga M, Sepulveda RV, Báez-Nieto D, González Leon C, González-Nilo F, Latorre R. J Biol Chem 290 2086-2098 (2015)
  14. CHEXVIS: a tool for molecular channel extraction and visualization. Masood TB, Sandhya S, Chandra N, Natarajan V. BMC Bioinformatics 16 119 (2015)
  15. Rational design and validation of a vanilloid-sensitive TRPV2 ion channel. Yang F, Vu S, Yarov-Yarovoy V, Zheng J. Proc Natl Acad Sci U S A 113 E3657-66 (2016)
  16. Role of the outer pore domain in transient receptor potential vanilloid 1 dynamic permeability to large cations. Munns CH, Chung MK, Sanchez YE, Amzel LM, Caterina MJ. J Biol Chem 290 5707-5724 (2015)
  17. The conformational wave in capsaicin activation of transient receptor potential vanilloid 1 ion channel. Yang F, Xiao X, Lee BH, Vu S, Yang W, Yarov-Yarovoy V, Zheng J. Nat Commun 9 2879 (2018)
  18. Temperature-sensitive gating of TRPV1 channel as probed by atomistic simulations of its trans- and juxtamembrane domains. Chugunov AO, Volynsky PE, Krylov NA, Nolde DE, Efremov RG. Sci Rep 6 33112 (2016)
  19. Membrane Protein Properties Revealed through Data-Rich Electrostatics Calculations. Marcoline FV, Bethel N, Guerriero CJ, Brodsky JL, Grabe M. Structure 23 1526-1537 (2015)
  20. A bimodal activation mechanism underlies scorpion toxin-induced pain. Yang S, Yang F, Zhang B, Lee BH, Li B, Luo L, Zheng J, Lai R. Sci Adv 3 e1700810 (2017)
  21. A combined coarse-grained and all-atom simulation of TRPV1 channel gating and heat activation. Zheng W, Qin F. J Gen Physiol 145 443-456 (2015)
  22. Structural determinants of the transient receptor potential 1 (TRPV1) channel activation by phospholipid analogs. Morales-Lázaro SL, Serrano-Flores B, Llorente I, Hernández-García E, González-Ramírez R, Banerjee S, Miller D, Gududuru V, Fells J, Norman D, Tigyi G, Escalante-Alcalde D, Rosenbaum T. J Biol Chem 289 24079-24090 (2014)
  23. Proton block of proton-activated TRPV1 current. Lee BH, Zheng J. J Gen Physiol 146 147-159 (2015)
  24. Direct Binding between Pre-S1 and TRP-like Domains in TRPP Channels Mediates Gating and Functional Regulation by PIP2. Zheng W, Cai R, Hofmann L, Nesin V, Hu Q, Long W, Fatehi M, Liu X, Hussein S, Kong T, Li J, Light PE, Tang J, Flockerzi V, Tsiokas L, Chen XZ. Cell Rep 22 1560-1573 (2018)
  25. Molecular basis for heat desensitization of TRPV1 ion channels. Luo L, Wang Y, Li B, Xu L, Kamau PM, Zheng J, Yang F, Yang S, Lai R. Nat Commun 10 2134 (2019)
  26. TRPV1 activation power can switch an action mode for its polypeptide ligands. Nikolaev MV, Dorofeeva NA, Komarova MS, Korolkova YV, Andreev YA, Mosharova IV, Grishin EV, Tikhonov DB, Kozlov SA. PLoS One 12 e0177077 (2017)
  27. TRPV1 function is modulated by Cdk5-mediated phosphorylation: insights into the molecular mechanism of nociception. Jendryke T, Prochazkova M, Hall BE, Nordmann GC, Schladt M, Milenkovic VM, Kulkarni AB, Wetzel CH. Sci Rep 6 22007 (2016)
  28. A hypothetical molecular mechanism for TRPV1 activation that invokes rotation of an S6 asparagine. Kasimova MA, Yazici AT, Yudin Y, Granata D, Klein ML, Rohacs T, Carnevale V. J Gen Physiol 150 1554-1566 (2018)
  29. Gating of human TRPV3 in a lipid bilayer. Deng Z, Maksaev G, Rau M, Xie Z, Hu H, Fitzpatrick JAJ, Yuan P. Nat Struct Mol Biol 27 635-644 (2020)
  30. Kunitz-Type Peptide HCRG21 from the Sea Anemone Heteractis crispa Is a Full Antagonist of the TRPV1 Receptor. Monastyrnaya M, Peigneur S, Zelepuga E, Sintsova O, Gladkikh I, Leychenko E, Isaeva M, Tytgat J, Kozlovskaya E. Mar Drugs 14 E229 (2016)
  31. Molecular Determinants of the Sensitivity to Gq/11-Phospholipase C-dependent Gating, Gd3+ Potentiation, and Ca2+ Permeability in the Transient Receptor Potential Canonical Type 5 (TRPC5) Channel. Chen X, Li W, Riley AM, Soliman M, Chakraborty S, Stamatkin CW, Obukhov AG. J Biol Chem 292 898-911 (2017)
  32. A Gate Hinge Controls the Epithelial Calcium Channel TRPV5. van der Wijst J, Leunissen EH, Blanchard MG, Venselaar H, Verkaart S, Paulsen CE, Bindels RJ, Hoenderop JG. Sci Rep 7 45489 (2017)
  33. The First Extracellular Linker Is Important for Several Aspects of the Gating Mechanism of Human TRPA1 Channel. Marsakova L, Barvik I, Zima V, Zimova L, Vlachova V. Front Mol Neurosci 10 16 (2017)
  34. The Outer Pore and Selectivity Filter of TRPA1. Christensen AP, Akyuz N, Corey DP. PLoS One 11 e0166167 (2016)
  35. Global alignment and assessment of TRP channel transmembrane domain structures to explore functional mechanisms. Huffer KE, Aleksandrova AA, Jara-Oseguera A, Forrest LR, Swartz KJ. Elife 9 e58660 (2020)
  36. Functional and Modeling Studies of the Transmembrane Region of the TRPM8 Channel. Bidaux G, Sgobba M, Lemonnier L, Borowiec AS, Noyer L, Jovanovic S, Zholos AV, Haider S. Biophys J 109 1840-1851 (2015)
  37. Toward elucidating the heat activation mechanism of the TRPV1 channel gating by molecular dynamics simulation. Wen H, Qin F, Zheng W. Proteins 84 1938-1949 (2016)
  38. Energetics of Ion Permeation in an Open-Activated TRPV1 Channel. Jorgensen C, Furini S, Domene C. Biophys J 111 1214-1222 (2016)
  39. Flexible Fitting of Atomic Models into Cryo-EM Density Maps Guided by Helix Correspondences. Dou H, Burrows DW, Baker ML, Ju T. Biophys J 112 2479-2493 (2017)
  40. Phosphorylation of the Transient Receptor Potential Ankyrin 1 by Cyclin-dependent Kinase 5 affects Chemo-nociception. Hall BE, Prochazkova M, Sapio MR, Minetos P, Kurochkina N, Binukumar BK, Amin ND, Terse A, Joseph J, Raithel SJ, Mannes AJ, Pant HC, Chung MK, Iadarola MJ, Kulkarni AB. Sci Rep 8 1177 (2018)
  41. Variability of Protein Structure Models from Electron Microscopy. Monroe L, Terashi G, Kihara D. Structure 25 592-602.e2 (2017)
  42. Ion-dependent structure, dynamics, and allosteric coupling in a non-selective cation channel. Lewis A, Kurauskas V, Tonelli M, Henzler-Wildman K. Nat Commun 12 6225 (2021)
  43. A centipede toxin causes rapid desensitization of nociceptor TRPV1 ion channel. Zhu A, Aierken A, Yao Z, Vu S, Tian Y, Zheng J, Yang S, Yang F. Toxicon 178 41-49 (2020)
  44. A fragment based method for modeling of protein segments into cryo-EM density maps. Ismer J, Rose AS, Tiemann JKS, Hildebrand PW. BMC Bioinformatics 18 475 (2017)
  45. Modeling Suggests TRPC3 Hydrogen Bonding and Not Phosphorylation Contributes to the Ataxia Phenotype of the Moonwalker Mouse. Hanson SM, Sansom MS, Becker EB. Biochemistry 54 4033-4041 (2015)
  46. Novel TRPV1 Channel Agonists With Faster and More Potent Analgesic Properties Than Capsaicin. Duarte Y, Cáceres J, Sepúlveda RV, Arriagada D, Olivares P, Díaz-Franulic I, Stehberg J, González-Nilo F. Front Pharmacol 11 1040 (2020)
  47. Human mutations highlight an intersubunit cation-π bond that stabilizes the closed but not open or inactivated states of TRPV channels. Teng J, Anishkin A, Kung C, Blount P. Proc Natl Acad Sci U S A 116 9410-9416 (2019)
  48. A new era for the design of TRPV1 antagonists and agonists with the use of structural information and molecular docking of capsaicin-like compounds. Caballero J. J Enzyme Inhib Med Chem 37 2169-2178 (2022)
  49. Computational Analysis of the Crystal and Cryo-EM Structures of P-Loop Channels with Drugs. Tikhonov DB, Zhorov BS. Int J Mol Sci 22 8143 (2021)
  50. Cost-Effective Pipeline for a Rational Design and Selection of Capsaicin Analogues Targeting TRPV1 Channels. Bustos D, Galarza C, Ordoñez W, Brauchi S, Benso B. ACS Omega 8 11736-11749 (2023)
  51. Discovery of a Novel Non-Narcotic Analgesic Derived from the CL-20 Explosive: Synthesis, Pharmacology, and Target Identification of Thiowurtzine, a Potent Inhibitor of the Opioid Receptors and the Ion Channels. Aguero S, Megy S, Eremina VV, Kalashnikov AI, Krylova SG, Kulagina DA, Lopatina KA, Fournier M, Povetyeva TN, Vorozhtsov AB, Sysolyatin SV, Zhdanov VV, Terreux R. ACS Omega 6 15400-15411 (2021)
  52. Molecular Dynamic Simulations Reveal the Activation Mechanisms of Oxidation-Induced TRPV1. Chu Y, Zhang H, Yang M, Yu R. Int J Mol Sci 24 9553 (2023)


Reviews citing this publication (189)

  1. How cryo-EM is revolutionizing structural biology. Bai XC, McMullan G, Scheres SH. Trends Biochem Sci 40 49-57 (2015)
  2. Mechanically Activated Ion Channels. Ranade SS, Syeda R, Patapoutian A. Neuron 87 1162-1179 (2015)
  3. Transient receptor potential channels in the vasculature. Earley S, Brayden JE. Physiol Rev 95 645-690 (2015)
  4. Structural Biology of the Major Facilitator Superfamily Transporters. Yan N. Annu Rev Biophys 44 257-283 (2015)
  5. Peripheral thermosensation in mammals. Vriens J, Nilius B, Voets T. Nat Rev Neurosci 15 573-589 (2014)
  6. TRPV4: Molecular Conductor of a Diverse Orchestra. White JP, Cibelli M, Urban L, Nilius B, McGeown JG, Nagy I. Physiol Rev 96 911-973 (2016)
  7. Signalling scaffolds and local organization of cellular behaviour. Langeberg LK, Scott JD. Nat Rev Mol Cell Biol 16 232-244 (2015)
  8. Unravelling biological macromolecules with cryo-electron microscopy. Fernandez-Leiro R, Scheres SH. Nature 537 339-346 (2016)
  9. Feeling the hidden mechanical forces in lipid bilayer is an original sense. Anishkin A, Loukin SH, Teng J, Kung C. Proc Natl Acad Sci U S A 111 7898-7905 (2014)
  10. Single-particle cryo-EM-How did it get here and where will it go. Cheng Y. Science 361 876-880 (2018)
  11. Allosteric Modulation as a Unifying Mechanism for Receptor Function and Regulation. Changeux JP, Christopoulos A. Cell 166 1084-1102 (2016)
  12. Challenges and opportunities in cryo-EM single-particle analysis. Lyumkis D. J Biol Chem 294 5181-5197 (2019)
  13. Cryo-EM in drug discovery: achievements, limitations and prospects. Renaud JP, Chari A, Ciferri C, Liu WT, Rémigy HW, Stark H, Wiesmann C. Nat Rev Drug Discov 17 471-492 (2018)
  14. Understand spiciness: mechanism of TRPV1 channel activation by capsaicin. Yang F, Zheng J. Protein Cell 8 169-177 (2017)
  15. The G protein-coupled receptor-transient receptor potential channel axis: molecular insights for targeting disorders of sensation and inflammation. Veldhuis NA, Poole DP, Grace M, McIntyre P, Bunnett NW. Pharmacol Rev 67 36-73 (2015)
  16. The force-from-lipid (FFL) principle of mechanosensitivity, at large and in elements. Teng J, Loukin S, Anishkin A, Kung C. Pflugers Arch 467 27-37 (2015)
  17. In Situ Cryo-Electron Tomography: A Post-Reductionist Approach to Structural Biology. Asano S, Engel BD, Baumeister W. J Mol Biol 428 332-343 (2016)
  18. Sensory TRP channels: the key transducers of nociception and pain. Mickle AD, Shepherd AJ, Mohapatra DP. Prog Mol Biol Transl Sci 131 73-118 (2015)
  19. Transient Receptor Potential (TRP) Channels. Samanta A, Hughes TET, Moiseenkova-Bell VY. Subcell Biochem 87 141-165 (2018)
  20. Forcing open TRP channels: Mechanical gating as a unifying activation mechanism. Liu C, Montell C. Biochem Biophys Res Commun 460 22-25 (2015)
  21. Why do we study animal toxins? Zhang Y. Dongwuxue Yanjiu 36 183-222 (2015)
  22. Advances in the field of single-particle cryo-electron microscopy over the last decade. Frank J. Nat Protoc 12 209-212 (2017)
  23. Vascular TRP channels: performing under pressure and going with the flow. Hill-Eubanks DC, Gonzales AL, Sonkusare SK, Nelson MT. Physiology (Bethesda) 29 343-360 (2014)
  24. Learning by failing: ideas and concepts to tackle γ-secretases in Alzheimer's disease and beyond. De Strooper B, Chávez Gutiérrez L. Annu Rev Pharmacol Toxicol 55 419-437 (2015)
  25. Amphipols for each season. Zoonens M, Popot JL. J Membr Biol 247 759-796 (2014)
  26. The recombinant expression systems for structure determination of eukaryotic membrane proteins. He Y, Wang K, Yan N. Protein Cell 5 658-672 (2014)
  27. Spider venomics: implications for drug discovery. Pineda SS, Undheim EA, Rupasinghe DB, Ikonomopoulou MP, King GF. Future Med Chem 6 1699-1714 (2014)
  28. TRP Channels in Skin Biology and Pathophysiology. Caterina MJ, Pang Z. Pharmaceuticals (Basel) 9 E77 (2016)
  29. Resolution advances in cryo-EM enable application to drug discovery. Subramaniam S, Earl LA, Falconieri V, Milne JL, Egelman EH. Curr Opin Struct Biol 41 194-202 (2016)
  30. TRPs in Pain Sensation. Jardín I, López JJ, Diez R, Sánchez-Collado J, Cantonero C, Albarrán L, Woodard GE, Redondo PC, Salido GM, Smani T, Rosado JA. Front Physiol 8 392 (2017)
  31. The molecular and cellular basis of thermosensation in mammals. Palkar R, Lippoldt EK, McKemy DD. Curr Opin Neurobiol 34 14-19 (2015)
  32. Na+ channel function, regulation, structure, trafficking and sequestration. Chen-Izu Y, Shaw RM, Pitt GS, Yarov-Yarovoy V, Sack JT, Abriel H, Aldrich RW, Belardinelli L, Cannell MB, Catterall WA, Chazin WJ, Chiamvimonvat N, Deschenes I, Grandi E, Hund TJ, Izu LT, Maier LS, Maltsev VA, Marionneau C, Mohler PJ, Rajamani S, Rasmusson RL, Sobie EA, Clancy CE, Bers DM. J Physiol 593 1347-1360 (2015)
  33. Phosphoinositide regulation of TRPV1 revisited. Rohacs T. Pflugers Arch 467 1851-1869 (2015)
  34. Targeting TRP channels for novel migraine therapeutics. Dussor G, Yan J, Xie JY, Ossipov MH, Dodick DW, Porreca F. ACS Chem Neurosci 5 1085-1096 (2014)
  35. ThermoTRPs and Pain. Laing RJ, Dhaka A. Neuroscientist 22 171-187 (2016)
  36. TRPV1: A Target for Rational Drug Design. Carnevale V, Rohacs T. Pharmaceuticals (Basel) 9 E52 (2016)
  37. Membrane protein structural biology in the era of single particle cryo-EM. Cheng Y. Curr Opin Struct Biol 52 58-63 (2018)
  38. Cryo electron microscopy to determine the structure of macromolecular complexes. Carroni M, Saibil HR. Methods 95 78-85 (2016)
  39. Dawning of a new era in TRP channel structural biology by cryo-electron microscopy. Madej MG, Ziegler CM. Pflugers Arch 470 213-225 (2018)
  40. Functional diversity and evolutionary dynamics of thermoTRP channels. Saito S, Tominaga M. Cell Calcium 57 214-221 (2015)
  41. Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014). Lee Y, Hong S, Cui M, Sharma PK, Lee J, Choi S. Expert Opin Ther Pat 25 291-318 (2015)
  42. High-resolution cryo-EM: the nuts and bolts. Elmlund D, Le SN, Elmlund H. Curr Opin Struct Biol 46 1-6 (2017)
  43. Involvement of TRPV1 Channels in Energy Homeostasis. Christie S, Wittert GA, Li H, Page AJ. Front Endocrinol (Lausanne) 9 420 (2018)
  44. Natural product modulators of transient receptor potential (TRP) channels as potential anti-cancer agents. Rodrigues T, Sieglitz F, Bernardes GJ. Chem Soc Rev 45 6130-6137 (2016)
  45. Physiological significance of TRPV2 as a mechanosensor, thermosensor and lipid sensor. Shibasaki K. J Physiol Sci 66 359-365 (2016)
  46. Harnessing the Therapeutic Potential of Capsaicin and Its Analogues in Pain and Other Diseases. Basith S, Cui M, Hong S, Choi S. Molecules 21 E966 (2016)
  47. Structural biology of TRP channels. Hellmich UA, Gaudet R. Handb Exp Pharmacol 223 963-990 (2014)
  48. TRPM3 in temperature sensing and beyond. Held K, Voets T, Vriens J. Temperature (Austin) 2 201-213 (2015)
  49. Transient Receptor Potential Channels and Endothelial Cell Calcium Signaling. Thakore P, Earley S. Compr Physiol 9 1249-1277 (2019)
  50. Transient receptor potential channels as targets for phytochemicals. Premkumar LS. ACS Chem Neurosci 5 1117-1130 (2014)
  51. Complexins: small but capable. Mohrmann R, Dhara M, Bruns D. Cell Mol Life Sci 72 4221-4235 (2015)
  52. Cryogenic electron microscopy and single-particle analysis. Elmlund D, Elmlund H. Annu Rev Biochem 84 499-517 (2015)
  53. Species-specific temperature sensitivity of TRPA1. Laursen WJ, Anderson EO, Hoffstaetter LJ, Bagriantsev SN, Gracheva EO. Temperature (Austin) 2 214-226 (2015)
  54. Thermally activated TRP channels: molecular sensors for temperature detection. Castillo K, Diaz-Franulic I, Canan J, Gonzalez-Nilo F, Latorre R. Phys Biol 15 021001 (2018)
  55. Factors that Influence the Formation and Stability of Thin, Cryo-EM Specimens. Glaeser RM, Han BG, Csencsits R, Killilea A, Pulk A, Cate JH. Biophys J 110 749-755 (2016)
  56. Tools for Understanding Nanoscale Lipid Regulation of Ion Channels. Robinson CV, Rohacs T, Hansen SB. Trends Biochem Sci 44 795-806 (2019)
  57. A Glimpse of Membrane Transport through Structures-Advances in the Structural Biology of the GLUT Glucose Transporters. Yan N. J Mol Biol 429 2710-2725 (2017)
  58. Versatile Roles of Intracellularly Located TRPV1 Channel. Zhao R, Tsang SY. J Cell Physiol 232 1957-1965 (2017)
  59. Endoplasmic reticulum stress in insulin resistance and diabetes. Guerrero-Hernández A, Leon-Aparicio D, Chavez-Reyes J, Olivares-Reyes JA, DeJesus S. Cell Calcium 56 311-322 (2014)
  60. Folding and stability of integral membrane proteins in amphipols. Kleinschmidt JH, Popot JL. Arch Biochem Biophys 564 327-343 (2014)
  61. Allosterism and Structure in Thermally Activated Transient Receptor Potential Channels. Diaz-Franulic I, Poblete H, Miño-Galaz G, González C, Latorre R. Annu Rev Biophys 45 371-398 (2016)
  62. Magnetic control of cellular processes using biofunctional nanoparticles. Monzel C, Vicario C, Piehler J, Coppey M, Dahan M. Chem Sci 8 7330-7338 (2017)
  63. Membrane protein structures without crystals, by single particle electron cryomicroscopy. Vinothkumar KR. Curr Opin Struct Biol 33 103-114 (2015)
  64. Remarkable Progress with Small-Molecule Modulation of TRPC1/4/5 Channels: Implications for Understanding the Channels in Health and Disease. Minard A, Bauer CC, Wright DJ, Rubaiy HN, Muraki K, Beech DJ, Bon RS. Cells 7 E52 (2018)
  65. Sample preparation of biological macromolecular assemblies for the determination of high-resolution structures by cryo-electron microscopy. Stark H, Chari A. Microscopy (Oxf) 65 23-34 (2016)
  66. Toward a high-resolution structure of IP₃R channel. Serysheva II. Cell Calcium 56 125-132 (2014)
  67. Transient Receptor Potential Channels and Calcium Signaling. Vangeel L, Voets T. Cold Spring Harb Perspect Biol 11 a035048 (2019)
  68. How lipids contribute to ion channel function, a fat perspective on direct and indirect interactions. Cordero-Morales JF, Vásquez V. Curr Opin Struct Biol 51 92-98 (2018)
  69. TRP channels: a missing bond in the entrainment mechanism of peripheral clocks throughout evolution. Poletini MO, Moraes MN, Ramos BC, Jerônimo R, Castrucci AM. Temperature (Austin) 2 522-534 (2015)
  70. The Mysteries of Capsaicin-Sensitive Afferents. Fischer MJM, Ciotu CI, Szallasi A. Front Physiol 11 554195 (2020)
  71. The S4---S5 linker - gearbox of TRP channel gating. Hofmann L, Wang H, Zheng W, Philipp SE, Hidalgo P, Cavalié A, Chen XZ, Beck A, Flockerzi V. Cell Calcium 67 156-165 (2017)
  72. Organellar TRP channels. Zhang X, Hu M, Yang Y, Xu H. Nat Struct Mol Biol 25 1009-1018 (2018)
  73. TRPV4: A Physio and Pathophysiologically Significant Ion Channel. Rosenbaum T, Benítez-Angeles M, Sánchez-Hernández R, Morales-Lázaro SL, Hiriart M, Morales-Buenrostro LE, Torres-Quiroz F. Int J Mol Sci 21 E3837 (2020)
  74. The Ca2+-Permeable Cation Transient Receptor Potential TRPV3 Channel: An Emerging Pivotal Target for Itch and Skin Diseases. Wang G, Wang K. Mol Pharmacol 92 193-200 (2017)
  75. Two promising future developments of cryo-EM: capturing short-lived states and mapping a continuum of states of a macromolecule. Chen B, Frank J. Microscopy (Oxf) 65 69-79 (2016)
  76. Allosteric modulation as a unifying mechanism for receptor function and regulation. Changeux JP, Christopoulos A. Diabetes Obes Metab 19 Suppl 1 4-21 (2017)
  77. Application of amphipols for structure-functional analysis of TRP channels. Huynh KW, Cohen MR, Moiseenkova-Bell VY. J Membr Biol 247 843-851 (2014)
  78. New approaches towards the understanding of integral membrane proteins: A structural perspective on G protein-coupled receptors. Grisshammer R. Protein Sci 26 1493-1504 (2017)
  79. Polyamine-mediated channel block of ionotropic glutamate receptors and its regulation by auxiliary proteins. Bowie D. J Biol Chem 293 18789-18802 (2018)
  80. TRPV4 ion channel as important cell sensors. Shibasaki K. J Anesth 30 1014-1019 (2016)
  81. Generalized single-particle cryo-EM--a historical perspective. Frank J. Microscopy (Oxf) 65 3-8 (2016)
  82. Integrative Modeling of Macromolecular Assemblies from Low to Near-Atomic Resolution. Xu X, Yan C, Wohlhueter R, Ivanov I. Comput Struct Biotechnol J 13 492-503 (2015)
  83. Spectator no more, the role of the membrane in regulating ion channel function. Pliotas C, Naismith JH. Curr Opin Struct Biol 45 59-66 (2017)
  84. Structural mechanisms of transient receptor potential ion channels. Cao E. J Gen Physiol 152 e201811998 (2020)
  85. TRP Channels as Potential Targets for Sex-Related Differences in Migraine Pain. Artero-Morales M, González-Rodríguez S, Ferrer-Montiel A. Front Mol Biosci 5 73 (2018)
  86. The mechanosensitive Piezo1 channel: structural features and molecular bases underlying its ion permeation and mechanotransduction. Wang Y, Xiao B. J Physiol 596 969-978 (2018)
  87. Electron Cryo-microscopy as a Tool for Structure-Based Drug Development. Merino F, Raunser S. Angew Chem Int Ed Engl 56 2846-2860 (2017)
  88. New Structures and Gating of Voltage-Dependent Potassium (Kv) Channels and Their Relatives: A Multi-Domain and Dynamic Question. Barros F, Pardo LA, Domínguez P, Sierra LM, de la Peña P. Int J Mol Sci 20 E248 (2019)
  89. TRP channels in schistosomes. Bais S, Greenberg RM. Int J Parasitol Drugs Drug Resist 6 335-342 (2016)
  90. Evolutionary tuning of TRPA1 and TRPV1 thermal and chemical sensitivity in vertebrates. Saito S, Tominaga M. Temperature (Austin) 4 141-152 (2017)
  91. Membrane mimetic systems in CryoEM: keeping membrane proteins in their native environment. Autzen HE, Julius D, Cheng Y. Curr Opin Struct Biol 58 259-268 (2019)
  92. Pain-Causing Venom Peptides: Insights into Sensory Neuron Pharmacology. Jami S, Erickson A, Brierley SM, Vetter I. Toxins (Basel) 10 E15 (2017)
  93. Receptor-Receptor Interactions as a Widespread Phenomenon: Novel Targets for Drug Development? Guidolin D, Marcoli M, Tortorella C, Maura G, Agnati LF. Front Endocrinol (Lausanne) 10 53 (2019)
  94. Single-particle cryo-electron microscopy of macromolecular complexes. Skiniotis G, Southworth DR. Microscopy (Oxf) 65 9-22 (2016)
  95. Structural studies of the C-terminal tail of polycystin-2 (PC2) reveal insights into the mechanisms used for the functional regulation of PC2. Yang Y, Ehrlich BE. J Physiol 594 4141-4149 (2016)
  96. Structure of thermally activated TRP channels. Cohen MR, Moiseenkova-Bell VY. Curr Top Membr 74 181-211 (2014)
  97. The role of π-helices in TRP channel gating. Zubcevic L, Lee SY. Curr Opin Struct Biol 58 314-323 (2019)
  98. Animal Toxins Providing Insights into TRPV1 Activation Mechanism. Geron M, Hazan A, Priel A. Toxins (Basel) 9 E326 (2017)
  99. Are sensory TRP channels biological alarms for lipid peroxidation? Choi SI, Yoo S, Lim JY, Hwang SW. Int J Mol Sci 15 16430-16457 (2014)
  100. Regulation of TRP channels by steroids: Implications in physiology and diseases. Kumar A, Kumari S, Majhi RK, Swain N, Yadav M, Goswami C. Gen Comp Endocrinol 220 23-32 (2015)
  101. TRPV1: Structure, Endogenous Agonists, and Mechanisms. Benítez-Angeles M, Morales-Lázaro SL, Juárez-González E, Rosenbaum T. Int J Mol Sci 21 E3421 (2020)
  102. The Role of Toxins in the Pursuit for Novel Analgesics. Maatuf Y, Geron M, Priel A. Toxins (Basel) 11 E131 (2019)
  103. While the revolution will not be crystallized, biochemistry reigns supreme. Takizawa Y, Binshtein E, Erwin AL, Pyburn TM, Mittendorf KF, Ohi MD. Protein Sci 26 69-81 (2017)
  104. Electron Microscopy: From 2D to 3D Images with Special Reference to Muscle. Franzini-Armstrong C. Eur J Transl Myol 25 4836 (2015)
  105. Endothelial TRPV1 as an Emerging Molecular Target to Promote Therapeutic Angiogenesis. Negri S, Faris P, Rosti V, Antognazza MR, Lodola F, Moccia F. Cells 9 E1341 (2020)
  106. Heat activation mechanism of TRPV1: New insights from molecular dynamics simulation. Zheng W, Wen H. Temperature (Austin) 6 120-131 (2019)
  107. Involvement of calcium channels in the regulation of adipogenesis. Zhai M, Yang D, Yi W, Sun W. Adipocyte 9 132-141 (2020)
  108. Never at rest: insights into the conformational dynamics of ion channels from cryo-electron microscopy. Lau C, Hunter MJ, Stewart A, Perozo E, Vandenberg JI. J Physiol 596 1107-1119 (2018)
  109. Nociceptor Signalling through ion Channel Regulation via GPCRs. Salzer I, Ray S, Schicker K, Boehm S. Int J Mol Sci 20 E2488 (2019)
  110. Sensory TRP channel interactions with endogenous lipids and their biological outcomes. Yoo S, Lim JY, Hwang SW. Molecules 19 4708-4744 (2014)
  111. Single-Particle Cryo-EM of the Ryanodine Receptor Channel in an Aqueous Environment. Baker MR, Fan G, Serysheva II. Eur J Transl Myol 25 4803 (2015)
  112. Soluble Epoxide Hydrolase Regulation of Lipid Mediators Limits Pain. Wagner KM, Gomes A, McReynolds CB, Hammock BD. Neurotherapeutics 17 900-916 (2020)
  113. Structure-Driven Pharmacology of Transient Receptor Potential Channel Vanilloid 1. Díaz-Franulic I, Caceres-Molina J, Sepulveda RV, Gonzalez-Nilo F, Latorre R. Mol Pharmacol 90 300-308 (2016)
  114. Function and dynamics of macromolecular complexes explored by integrative structural and computational biology. Purdy MD, Bennett BC, McIntire WE, Khan AK, Kasson PM, Yeager M. Curr Opin Struct Biol 27 138-148 (2014)
  115. Global versus local mechanisms of temperature sensing in ion channels. Arrigoni C, Minor DL. Pflugers Arch 470 733-744 (2018)
  116. Modulation of the Activities of Neuronal Ion Channels by Fatty Acid-Derived Pro-Resolvents. Choi G, Hwang SW. Front Physiol 7 523 (2016)
  117. Structural insights into the transport of small molecules across membranes. Noinaj N, Buchanan SK. Curr Opin Struct Biol 27 8-15 (2014)
  118. The (Poly)Pharmacology of Cannabidiol in Neurological and Neuropsychiatric Disorders: Molecular Mechanisms and Targets. Vitale RM, Iannotti FA, Amodeo P. Int J Mol Sci 22 4876 (2021)
  119. Capsaicin-Sensitive Sensory Nerves and the TRPV1 Ion Channel in Cardiac Physiology and Pathologies. Szabados T, Gömöri K, Pálvölgyi L, Görbe A, Baczkó I, Helyes Z, Jancsó G, Ferdinandy P, Bencsik P. Int J Mol Sci 21 E4472 (2020)
  120. Molecular mechanisms of temperature adaptation. Bagriantsev SN, Gracheva EO. J Physiol 593 3483-3491 (2015)
  121. Pore size matters for potassium channel conductance. Naranjo D, Moldenhauer H, Pincuntureo M, Díaz-Franulic I. J Gen Physiol 148 277-291 (2016)
  122. To flourish or perish: evolutionary TRiPs into the sensory biology of plant-herbivore interactions. Startek JB, Voets T, Talavera K. Pflugers Arch 471 213-236 (2019)
  123. Transient receptor potential (TRP) channels: a metabolic TR(i)P to obesity prevention and therapy. Bishnoi M, Khare P, Brown L, Panchal SK. Obes Rev 19 1269-1292 (2018)
  124. What is new about mild temperature sensing? A review of recent findings. García-Ávila M, Islas LD. Temperature (Austin) 6 132-141 (2019)
  125. Changes in Membrane Protein Structural Biology. Birch J, Cheruvara H, Gamage N, Harrison PJ, Lithgo R, Quigley A. Biology (Basel) 9 E401 (2020)
  126. Evolutionary dynamics of metazoan TRP channels. Kadowaki T. Pflugers Arch 467 2043-2053 (2015)
  127. High-resolution structures of transient receptor potential vanilloid channels: Unveiling a functionally diverse group of ion channels. van Goor MK, de Jager L, Cheng Y, van der Wijst J. Protein Sci 29 1569-1580 (2020)
  128. Structure and function of polycystin channels in primary cilia. Ta CM, Vien TN, Ng LCT, DeCaen PG. Cell Signal 72 109626 (2020)
  129. The Pivotal Role of TRP Channels in Homeostasis and Diseases throughout the Gastrointestinal Tract. Alaimo A, Rubert J. Int J Mol Sci 20 E5277 (2019)
  130. Beyond Neuronal Heat Sensing: Diversity of TRPV1 Heat-Capsaicin Receptor-Channel Functions. Shuba YM. Front Cell Neurosci 14 612480 (2020)
  131. Highlighting membrane protein structure and function: A celebration of the Protein Data Bank. Li F, Egea PF, Vecchio AJ, Asial I, Gupta M, Paulino J, Bajaj R, Dickinson MS, Ferguson-Miller S, Monk BC, Stroud RM. J Biol Chem 296 100557 (2021)
  132. Natural product modulators of human sensations and mood: molecular mechanisms and therapeutic potential. Pluskal T, Weng JK. Chem Soc Rev 47 1592-1637 (2018)
  133. Simulation-Based Methods for Model Building and Refinement in Cryoelectron Microscopy. Dodd T, Yan C, Ivanov I. J Chem Inf Model 60 2470-2483 (2020)
  134. Structure and function of the calcium-selective TRP channel TRPV6. Yelshanskaya MV, Nadezhdin KD, Kurnikova MG, Sobolevsky AI. J Physiol 599 2673-2697 (2021)
  135. Structure of an innexin gap junction channel and cryo-EM sample preparation. Oshima A. Microscopy (Oxf) 66 371-379 (2017)
  136. The transient receptor potential cation channel subfamily V member 6 (TRPV6): genetics, biochemical properties, and functions of exceptional calcium channel proteins. Stoerger C, Flockerzi V. Biochem Cell Biol 92 441-448 (2014)
  137. A painful link between the TRPV1 channel and lysophosphatidic acid. Morales-Lázaro SL, Rosenbaum T. Life Sci 125 15-24 (2015)
  138. Advances in methods for atomic resolution macromolecular structure determination. Thompson MC, Yeates TO, Rodriguez JA. F1000Res 9 F1000 Faculty Rev-667 (2020)
  139. Biological Applications at the Cutting Edge of Cryo-Electron Microscopy. Dillard RS, Hampton CM, Strauss JD, Ke Z, Altomara D, Guerrero-Ferreira RC, Kiss G, Wright ER. Microsc Microanal 24 406-419 (2018)
  140. Mechanism of TRPM2 channel gating revealed by cryo-EM. Xia S, Wang L, Fu TM, Wu H. FEBS J 286 3333-3339 (2019)
  141. TRPV1 in chronic pruritus and pain: Soft modulation as a therapeutic strategy. Fernández-Carvajal A, Fernández-Ballester G, Ferrer-Montiel A. Front Mol Neurosci 15 930964 (2022)
  142. Electron cryomicroscopy as a powerful tool in biomedical research. Quentin D, Raunser S. J Mol Med (Berl) 96 483-493 (2018)
  143. Evolutionary Aspects of TRPMLs and TPCs. Jaślan D, Böck J, Krogsaeter E, Grimm C. Int J Mol Sci 21 E4181 (2020)
  144. Modelling the interactions between animal venom peptides and membrane proteins. Hung A, Kuyucak S, Schroeder CI, Kaas Q. Neuropharmacology 127 20-31 (2017)
  145. Molecular mechanisms of coupling to voltage sensors in voltage-evoked cellular signals. Okamura Y, Okochi Y. Proc Jpn Acad Ser B Phys Biol Sci 95 111-135 (2019)
  146. Armed stem to stinger: a review of the ecological roles of scorpion weapons. Simone Y, van der Meijden A. J Venom Anim Toxins Incl Trop Dis 27 e20210002 (2021)
  147. Deciphering Subtype-Selective Modulations in TRPA1 Biosensor Channels. Kozai D, Sakaguchi R, Ohwada T, Mori Y. Curr Neuropharmacol 13 266-278 (2015)
  148. Genetic strategies to analyze primary TRP channel-expressing cells in mice. Wyatt A, Wartenberg P, Candlish M, Krasteva-Christ G, Flockerzi V, Boehm U. Cell Calcium 67 91-104 (2017)
  149. Cannabinoids and Neurogenesis: The Promised Solution for Neurodegeneration? Valeri A, Mazzon E. Molecules 26 6313 (2021)
  150. Cryo-electron microscopy for structural biology: current status and future perspectives. Wang H. Sci China Life Sci 58 750-756 (2015)
  151. Druggable Lipid Binding Sites in Pentameric Ligand-Gated Ion Channels and Transient Receptor Potential Channels. Cheng WWL, Arcario MJ, Petroff JT. Front Physiol 12 798102 (2021)
  152. Function and therapeutic potential of transient receptor potential ankyrin 1 in fibrosis. Wei Y, Cai J, Zhu R, Xu K, Li H, Li J. Front Pharmacol 13 1014041 (2022)
  153. Involvement of TRP Channels in Adipocyte Thermogenesis: An Update. Sun W, Luo Y, Zhang F, Tang S, Zhu T. Front Cell Dev Biol 9 686173 (2021)
  154. Molecular dynamics: a powerful tool for studying the medicinal chemistry of ion channel modulators. Şterbuleac D. RSC Med Chem 12 1503-1518 (2021)
  155. Nobel somatosensations and pain. Reeh PW, Fischer MJM. Pflugers Arch 474 405-420 (2022)
  156. TRPV1: Role in Skin and Skin Diseases and Potential Target for Improving Wound Healing. Bagood MD, Isseroff RR. Int J Mol Sci 22 6135 (2021)
  157. The envenomation of general physiology throughout the last century. Sack JT. J Gen Physiol 149 975-983 (2017)
  158. Towards the Idea of Molecular Brains. Timsit Y, Grégoire SP. Int J Mol Sci 22 11868 (2021)
  159. Transient Receptor Potential (TRP) Channels in Pain, Neuropsychiatric Disorders, and Epilepsy. Yang F, Sivils A, Cegielski V, Singh S, Chu XP. Int J Mol Sci 24 4714 (2023)
  160. Understanding diverse TRPV1 signaling - an update. Andresen MC. F1000Res 8 F1000 Faculty Rev-1978 (2019)
  161. [Progress on structural biology of voltage-gated ion channels]. Song F, Guo J. Zhejiang Da Xue Xue Bao Yi Xue Ban 48 25-33 (2019)
  162. A bibliometrics analysis and visualization study of TRPV1 channel. Gao N, Li M, Wang W, Liu Z, Guo Y. Front Pharmacol 14 1076921 (2023)
  163. A molecular perspective on identifying TRPV1 thermosensitive regions and disentangling polymodal activation. Luu DD, Owens AM, Mebrat MD, Van Horn WD. Temperature (Austin) 10 67-101 (2023)
  164. Comprehensive Survey of Consensus Docking for High-Throughput Virtual Screening. Blanes-Mira C, Fernández-Aguado P, de Andrés-López J, Fernández-Carvajal A, Ferrer-Montiel A, Fernández-Ballester G. Molecules 28 175 (2022)
  165. CryoEM Reveals the Complexity and Diversity of ATP Synthases. Courbon GM, Rubinstein JL. Front Microbiol 13 864006 (2022)
  166. Deciphering Molecular Mechanisms and Intervening in Physiological and Pathophysiological Processes of Ca2+ Signaling Mechanisms Using Optogenetic Tools. Maltan L, Najjar H, Tiffner A, Derler I. Cells 10 3340 (2021)
  167. Detergents and alternatives in cryo-EM studies of membrane proteins. Li S. Acta Biochim Biophys Sin (Shanghai) 54 1049-1056 (2022)
  168. Does Transient Receptor Potential Vanilloid Type 1 Alleviate or Aggravate Pathological Myocardial Hypertrophy? Yan Q, Tang J, Zhang X, Wu L, Xu Y, Wang L. Front Pharmacol 12 681286 (2021)
  169. Function-Related Dynamics in Multi-Spanning Helical Membrane Proteins Revealed by Solution NMR. Takeuchi K, Kofuku Y, Imai S, Ueda T, Tokunaga Y, Toyama Y, Shiraishi Y, Shimada I. Membranes (Basel) 11 604 (2021)
  170. Impact of TRPV1 on Pathogenesis and Therapy of Neurodegenerative Diseases. Wang W, Sun T. Molecules 29 181 (2023)
  171. Inferiority complex: why do sensory ion channels multimerize? Gamper N, Shah S. Biochem Soc Trans 50 213-222 (2022)
  172. Lipid-dependent sequential allosteric activation of heat-sensing TRPV1 channels by anchor-stereoselective "hot" vanilloid compounds and analogs. Wang G. Biochem Biophys Rep 28 101109 (2021)
  173. Molecular pharmacology of the onco-TRP channel TRPV6. Neuberger A, Sobolevsky AI. Channels (Austin) 17 2266669 (2023)
  174. Natural Active Ingredients and TRPV1 Modulation: Focus on Key Chemical Moieties Involved in Ligand-Target Interaction. Andrei C, Zanfirescu A, Nițulescu GM, Olaru OT, Negreș S. Plants (Basel) 12 339 (2023)
  175. New Horizons in Structural Biology of Membrane Proteins: Experimental Evaluation of the Role of Conformational Dynamics and Intrinsic Flexibility. Puthenveetil R, Christenson ET, Vinogradova O. Membranes (Basel) 12 227 (2022)
  176. Nociceptor-Macrophage Interactions in Apical Periodontitis: How Biomolecules Link Inflammation with Pain. Menon N, Kishen A. Biomolecules 13 1193 (2023)
  177. Overview of Membrane Protein Sample Preparation for Single-Particle Cryo-Electron Microscopy Analysis. Vénien-Bryan C, Fernandes CAH. Int J Mol Sci 24 14785 (2023)
  178. P-Loop Channels: Experimental Structures, and Physics-Based and Neural Networks-Based Models. Tikhonov DB, Zhorov BS. Membranes (Basel) 12 229 (2022)
  179. Polycystin Channel Complexes. Esarte Palomero O, Larmore M, DeCaen PG. Annu Rev Physiol 85 425-448 (2023)
  180. Progress in the Structural Basis of thermoTRP Channel Polymodal Gating. Fernández-Ballester G, Fernández-Carvajal A, Ferrer-Montiel A. Int J Mol Sci 24 743 (2023)
  181. Pungency Perception and the Interaction with Basic Taste Sensations: An Overview. He W, Liang L, Zhang Y. Foods 12 2317 (2023)
  182. Recent Advances in the Structural Biology of the Volume-Regulated Anion Channel LRRC8. Kasuya G, Nureki O. Front Pharmacol 13 896532 (2022)
  183. Resiniferatoxin: Nature's Precision Medicine to Silence TRPV1-Positive Afferents. Szallasi A. Int J Mol Sci 24 15042 (2023)
  184. Role of TRPV1 in High Temperature-Induced Mitochondrial Biogenesis in Skeletal Muscle: A Mini Review. Xu Y, Zhao Y, Gao B. Front Cell Dev Biol 10 882578 (2022)
  185. Sensory TRP Channels in Three Dimensions. Diver MM, Lin King JV, Julius D, Cheng Y. Annu Rev Biochem 91 629-649 (2022)
  186. Structural basis of properties, mechanisms, and channelopathy of cyclic nucleotide-gated channels. Hu Z, Yang J. Channels (Austin) 17 2273165 (2023)
  187. TRP channels: a journey towards a molecular understanding of pain. Rosenbaum T, Morales-Lázaro SL, Islas LD. Nat Rev Neurosci 23 596-610 (2022)
  188. TRPV1 in male reproductive system: focus on sperm function. Xiao W, Chen Y. Mol Cell Biochem 477 2567-2579 (2022)
  189. Venom Peptide Toxins Targeting the Outer Pore Region of Transient Receptor Potential Vanilloid 1 in Pain: Implications for Analgesic Drug Development. Hwang SM, Jo YY, Cohen CF, Kim YH, Berta T, Park CK. Int J Mol Sci 23 5772 (2022)

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  1. Structure of the TRPV1 ion channel determined by electron cryo-microscopy. Liao M, Cao E, Julius D, Cheng Y. Nature 504 107-112 (2013)
  2. Structure of the TRPA1 ion channel suggests regulatory mechanisms. Paulsen CE, Armache JP, Gao Y, Cheng Y, Julius D. Nature 520 511-517 (2015)
  3. Semi-automated selection of cryo-EM particles in RELION-1.3. Scheres SH. J Struct Biol 189 114-122 (2015)
  4. Chemical activation of the mechanotransduction channel Piezo1. Syeda R, Xu J, Dubin AE, Coste B, Mathur J, Huynh T, Matzen J, Lao J, Tully DC, Engels IH, Petrassi HM, Schumacher AM, Montal M, Bandell M, Patapoutian A. Elife 4 (2015)
  5. Structural mechanism underlying capsaicin binding and activation of the TRPV1 ion channel. Yang F, Xiao X, Cheng W, Yang W, Yu P, Song Z, Yarov-Yarovoy V, Zheng J. Nat Chem Biol 11 518-524 (2015)
  6. Structure of the cold- and menthol-sensing ion channel TRPM8. Yin Y, Wu M, Zubcevic L, Borschel WF, Lander GC, Lee SY. Science 359 237-241 (2018)
  7. Phytochemicals perturb membranes and promiscuously alter protein function. Ingólfsson HI, Thakur P, Herold KF, Hobart EA, Ramsey NB, Periole X, de Jong DH, Zwama M, Yilmaz D, Hall K, Maretzky T, Hemmings HC, Blobel C, Marrink SJ, Koçer A, Sack JT, Andersen OS. ACS Chem Biol 9 1788-1798 (2014)
  8. Crystal structure of the epithelial calcium channel TRPV6. Saotome K, Singh AK, Yelshanskaya MV, Sobolevsky AI. Nature 534 506-511 (2016)
  9. Structure of the human TRPM4 ion channel in a lipid nanodisc. Autzen HE, Myasnikov AG, Campbell MG, Asarnow D, Julius D, Cheng Y. Science 359 228-232 (2018)
  10. The Structure of the Polycystic Kidney Disease Channel PKD2 in Lipid Nanodiscs. Shen PS, Yang X, DeCaen PG, Liu X, Bulkley D, Clapham DE, Cao E. Cell 167 763-773.e11 (2016)
  11. Cryo-EM enters a new era. Kühlbrandt W. Elife 3 e03678 (2014)
  12. Alignment of cryo-EM movies of individual particles by optimization of image translations. Rubinstein JL, Brubaker MA. J Struct Biol 192 188-195 (2015)
  13. Channel opening and gating mechanism in AMPA-subtype glutamate receptors. Twomey EC, Yelshanskaya MV, Grassucci RA, Frank J, Sobolevsky AI. Nature 549 60-65 (2017)
  14. Electron cryo-microscopy structure of the mechanotransduction channel NOMPC. Jin P, Bulkley D, Guo Y, Zhang W, Guo Z, Huynh W, Wu S, Meltzer S, Cheng T, Jan LY, Jan YN, Cheng Y. Nature 547 118-122 (2017)
  15. International Union of Basic and Clinical Pharmacology. XC. multisite pharmacology: recommendations for the nomenclature of receptor allosterism and allosteric ligands. Christopoulos A, Changeux JP, Catterall WA, Fabbro D, Burris TP, Cidlowski JA, Olsen RW, Peters JA, Neubig RR, Pin JP, Sexton PM, Kenakin TP, Ehlert FJ, Spedding M, Langmead CJ. Pharmacol Rev 66 918-947 (2014)
  16. Electron cryo-microscopy structure of a human TRPM4 channel. Winkler PA, Huang Y, Sun W, Du J, Lü W. Nature 552 200-204 (2017)
  17. GABA blocks pathological but not acute TRPV1 pain signals. Hanack C, Moroni M, Lima WC, Wende H, Kirchner M, Adelfinger L, Schrenk-Siemens K, Tappe-Theodor A, Wetzel C, Kuich PH, Gassmann M, Roggenkamp D, Bettler B, Lewin GR, Selbach M, Siemens J. Cell 160 759-770 (2015)
  18. Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2). Grieben M, Pike AC, Shintre CA, Venturi E, El-Ajouz S, Tessitore A, Shrestha L, Mukhopadhyay S, Mahajan P, Chalk R, Burgess-Brown NA, Sitsapesan R, Huiskonen JT, Carpenter EP. Nat Struct Mol Biol 24 114-122 (2017)
  19. Cryo-EM and X-ray structures of TRPV4 reveal insight into ion permeation and gating mechanisms. Deng Z, Paknejad N, Maksaev G, Sala-Rabanal M, Nichols CG, Hite RK, Yuan P. Nat Struct Mol Biol 25 252-260 (2018)
  20. Structure and gating mechanism of the transient receptor potential channel TRPV3. Singh AK, McGoldrick LL, Sobolevsky AI. Nat Struct Mol Biol 25 805-813 (2018)
  21. Subnanometre-resolution electron cryomicroscopy structure of a heterodimeric ABC exporter. Kim J, Wu S, Tomasiak TM, Mergel C, Winter MB, Stiller SB, Robles-Colmanares Y, Stroud RM, Tampé R, Craik CS, Cheng Y. Nature 517 396-400 (2015)
  22. Transmembrane helix straightening and buckling underlies activation of mechanosensitive and thermosensitive K(2P) channels. Lolicato M, Riegelhaupt PM, Arrigoni C, Clark KA, Minor DL. Neuron 84 1198-1212 (2014)
  23. Structure of a TRPM2 channel in complex with Ca2+ explains unique gating regulation. Zhang Z, Tóth B, Szollosi A, Chen J, Csanády L. Elife 7 e36409 (2018)
  24. Structure of the receptor-activated human TRPC6 and TRPC3 ion channels. Tang Q, Guo W, Zheng L, Wu JX, Liu M, Zhou X, Zhang X, Chen L. Cell Res 28 746-755 (2018)
  25. A molecular framework for temperature-dependent gating of ion channels. Chowdhury S, Jarecki BW, Chanda B. Cell 158 1148-1158 (2014)
  26. Cryo-electron microscopy structure of the lysosomal calcium-permeable channel TRPML3. Hirschi M, Herzik MA, Wie J, Suo Y, Borschel WF, Ren D, Lander GC, Lee SY. Nature 550 411-414 (2017)
  27. Physical basis of apparent pore dilation of ATP-activated P2X receptor channels. Li M, Toombes GE, Silberberg SD, Swartz KJ. Nat Neurosci 18 1577-1583 (2015)
  28. Human TRPML1 channel structures in open and closed conformations. Schmiege P, Fine M, Blobel G, Li X. Nature 550 366-370 (2017)
  29. Evolution of TRP channels inferred by their classification in diverse animal species. Peng G, Shi X, Kadowaki T. Mol Phylogenet Evol 84 145-157 (2015)
  30. Photoswitchable fatty acids enable optical control of TRPV1. Frank JA, Moroni M, Moshourab R, Sumser M, Lewin GR, Trauner D. Nat Commun 6 7118 (2015)
  31. Englerin A Agonizes the TRPC4/C5 Cation Channels to Inhibit Tumor Cell Line Proliferation. Carson C, Raman P, Tullai J, Xu L, Henault M, Thomas E, Yeola S, Lao J, McPate M, Verkuyl JM, Marsh G, Sarber J, Amaral A, Bailey S, Lubicka D, Pham H, Miranda N, Ding J, Tang HM, Ju H, Tranter P, Ji N, Krastel P, Jain RK, Schumacher AM, Loureiro JJ, George E, Berellini G, Ross NT, Bushell SM, Erdemli G, Solomon JM. PLoS One 10 e0127498 (2015)
  32. Structure of the mouse TRPC4 ion channel. Duan J, Li J, Zeng B, Chen GL, Peng X, Zhang Y, Wang J, Clapham DE, Li Z, Zhang J. Nat Commun 9 3102 (2018)
  33. 2.8 Å resolution reconstruction of the Thermoplasma acidophilum 20S proteasome using cryo-electron microscopy. Campbell MG, Veesler D, Cheng A, Potter CS, Carragher B. Elife 4 (2015)
  34. Structural insights into TRPM8 inhibition and desensitization. Diver MM, Cheng Y, Julius D. Science 365 1434-1440 (2019)
  35. Structure of the mammalian TRPM7, a magnesium channel required during embryonic development. Duan J, Li Z, Li J, Hulse RE, Santa-Cruz A, Valinsky WC, Abiria SA, Krapivinsky G, Zhang J, Clapham DE. Proc Natl Acad Sci U S A 115 E8201-E8210 (2018)
  36. Unique interweaved microtubule scaffold mediates osmosensory transduction via physical interaction with TRPV1. Prager-Khoutorsky M, Khoutorsky A, Bourque CW. Neuron 83 866-878 (2014)
  37. Conformational ensemble of the human TRPV3 ion channel. Zubcevic L, Herzik MA, Wu M, Borschel WF, Hirschi M, Song AS, Lander GC, Lee SY. Nat Commun 9 4773 (2018)
  38. The TRPM8 protein is a testosterone receptor: II. Functional evidence for an ionotropic effect of testosterone on TRPM8. Asuthkar S, Demirkhanyan L, Sun X, Elustondo PA, Krishnan V, Baskaran P, Velpula KK, Thyagarajan B, Pavlov EV, Zakharian E. J Biol Chem 290 2670-2688 (2015)
  39. TRPV4 channel activity is modulated by direct interaction of the ankyrin domain to PI(4,5)P₂. Takahashi N, Hamada-Nakahara S, Itoh Y, Takemura K, Shimada A, Ueda Y, Kitamata M, Matsuoka R, Hanawa-Suetsugu K, Senju Y, Mori MX, Kiyonaka S, Kohda D, Kitao A, Mori Y, Suetsugu S. Nat Commun 5 4994 (2014)
  40. Elephantid Genomes Reveal the Molecular Bases of Woolly Mammoth Adaptations to the Arctic. Lynch VJ, Bedoya-Reina OC, Ratan A, Sulak M, Drautz-Moses DI, Perry GH, Miller W, Schuster SC. Cell Rep 12 217-228 (2015)
  41. GraDeR: Membrane Protein Complex Preparation for Single-Particle Cryo-EM. Hauer F, Gerle C, Fischer N, Oshima A, Shinzawa-Itoh K, Shimada S, Yokoyama K, Fujiyoshi Y, Stark H. Structure 23 1769-1775 (2015)
  42. Activation of TRPM7 channels by small molecules under physiological conditions. Hofmann T, Schäfer S, Linseisen M, Sytik L, Gudermann T, Chubanov V. Pflugers Arch 466 2177-2189 (2014)
  43. Modality-specific mechanisms of protein kinase C-induced hypersensitivity of TRPV1: S800 is a polymodal sensitization site. Wang S, Joseph J, Ro JY, Chung MK. Pain 156 931-941 (2015)
  44. Structural dynamics of potassium-channel gating revealed by single-molecule FRET. Wang S, Vafabakhsh R, Borschel WF, Ha T, Nichols CG. Nat Struct Mol Biol 23 31-36 (2016)
  45. Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states. McClenaghan C, Schewe M, Aryal P, Carpenter EP, Baukrowitz T, Tucker SJ. J Gen Physiol 147 497-505 (2016)
  46. Structural insight into tetrameric hTRPV1 from homology modeling, molecular docking, molecular dynamics simulation, virtual screening, and bioassay validations. Feng Z, Pearce LV, Xu X, Yang X, Yang P, Blumberg PM, Xie XQ. J Chem Inf Model 55 572-588 (2015)
  47. TRPM8 inhibits endothelial cell migration via a non-channel function by trapping the small GTPase Rap1. Genova T, Grolez GP, Camillo C, Bernardini M, Bokhobza A, Richard E, Scianna M, Lemonnier L, Valdembri D, Munaron L, Philips MR, Mattot V, Serini G, Prevarskaya N, Gkika D, Pla AF. J Cell Biol 216 2107-2130 (2017)
  48. An optically controlled probe identifies lipid-gating fenestrations within the TRPC3 channel. Lichtenegger M, Tiapko O, Svobodova B, Stockner T, Glasnov TN, Schreibmayer W, Platzer D, de la Cruz GG, Krenn S, Schober R, Shrestha N, Schindl R, Romanin C, Groschner K. Nat Chem Biol 14 396-404 (2018)
  49. Molecular mechanism of TRPV2 channel modulation by cannabidiol. Pumroy RA, Samanta A, Liu Y, Hughes TE, Zhao S, Yudin Y, Rohacs T, Han S, Moiseenkova-Bell VY. Elife 8 e48792 (2019)
  50. Hyaluronan modulates TRPV1 channel opening, reducing peripheral nociceptor activity and pain. Caires R, Luis E, Taberner FJ, Fernandez-Ballester G, Ferrer-Montiel A, Balazs EA, Gomis A, Belmonte C, de la Peña E. Nat Commun 6 8095 (2015)
  51. Low-cost functional plasticity of TRPV1 supports heat tolerance in squirrels and camels. Laursen WJ, Schneider ER, Merriman DK, Bagriantsev SN, Gracheva EO. Proc Natl Acad Sci U S A 113 11342-11347 (2016)
  52. Architecture of the heteromeric GluA1/2 AMPA receptor in complex with the auxiliary subunit TARP γ8. Herguedas B, Watson JF, Ho H, Cais O, García-Nafría J, Greger IH. Science 364 eaav9011 (2019)
  53. Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function. Gerndt S, Chen CC, Chao YK, Yuan Y, Burgstaller S, Scotto Rosato A, Krogsaeter E, Urban N, Jacob K, Nguyen ONP, Miller MT, Keller M, Vollmar AM, Gudermann T, Zierler S, Schredelseker J, Schaefer M, Biel M, Malli R, Wahl-Schott C, Bracher F, Patel S, Grimm C. Elife 9 e54712 (2020)
  54. Conformational plasticity in the selectivity filter of the TRPV2 ion channel. Zubcevic L, Le S, Yang H, Lee SY. Nat Struct Mol Biol 25 405-415 (2018)
  55. Structural basis of temperature sensation by the TRP channel TRPV3. Singh AK, McGoldrick LL, Demirkhanyan L, Leslie M, Zakharian E, Sobolevsky AI. Nat Struct Mol Biol 26 994-998 (2019)
  56. Temperature and voltage coupling to channel opening in transient receptor potential melastatin 8 (TRPM8). Raddatz N, Castillo JP, Gonzalez C, Alvarez O, Latorre R. J Biol Chem 289 35438-35454 (2014)
  57. Comparative sequence analysis suggests a conserved gating mechanism for TRP channels. Palovcak E, Delemotte L, Klein ML, Carnevale V. J Gen Physiol 146 37-50 (2015)
  58. Cryo-EM structure of TRPC5 at 2.8-Å resolution reveals unique and conserved structural elements essential for channel function. Duan J, Li J, Chen GL, Ge Y, Liu J, Xie K, Peng X, Zhou W, Zhong J, Zhang Y, Xu J, Xue C, Liang B, Zhu L, Liu W, Zhang C, Tian XL, Wang J, Clapham DE, Zeng B, Li Z, Zhang J. Sci Adv 5 eaaw7935 (2019)
  59. Measuring distances between TRPV1 and the plasma membrane using a noncanonical amino acid and transition metal ion FRET. Zagotta WN, Gordon MT, Senning EN, Munari MA, Gordon SE. J Gen Physiol 147 201-216 (2016)
  60. Regulation of TRPV1 ion channel by phosphoinositide (4,5)-bisphosphate: the role of membrane asymmetry. Senning EN, Collins MD, Stratiievska A, Ufret-Vincenty CA, Gordon SE. J Biol Chem 289 10999-11006 (2014)
  61. Structural insight into TRPV5 channel function and modulation. Dang S, van Goor MK, Asarnow D, Wang Y, Julius D, Cheng Y, van der Wijst J. Proc Natl Acad Sci U S A 116 8869-8878 (2019)
  62. High temperature sensitivity is intrinsic to voltage-gated potassium channels. Yang F, Zheng J. Elife 3 e03255 (2014)
  63. Mechanism for phosphoinositide selectivity and activation of TRPV1 ion channels. Ufret-Vincenty CA, Klein RM, Collins MD, Rosasco MG, Martinez GQ, Gordon SE. J Gen Physiol 145 431-442 (2015)
  64. Discovery of peptide ligands through docking and virtual screening at nicotinic acetylcholine receptor homology models. Leffler AE, Kuryatov A, Zebroski HA, Powell SR, Filipenko P, Hussein AK, Gorson J, Heizmann A, Lyskov S, Tsien RW, Poget SF, Nicke A, Lindstrom J, Rudy B, Bonneau R, Holford M. Proc Natl Acad Sci U S A 114 E8100-E8109 (2017)
  65. Hydrophobic pore gates regulate ion permeation in polycystic kidney disease 2 and 2L1 channels. Zheng W, Yang X, Hu R, Cai R, Hofmann L, Wang Z, Hu Q, Liu X, Bulkley D, Yu Y, Tang J, Flockerzi V, Cao Y, Cao E, Chen XZ. Nat Commun 9 2302 (2018)
  66. L596-W733 bond between the start of the S4-S5 linker and the TRP box stabilizes the closed state of TRPV4 channel. Teng J, Loukin SH, Anishkin A, Kung C. Proc Natl Acad Sci U S A 112 3386-3391 (2015)
  67. TRPV1 mediates cellular uptake of anandamide and thus promotes endothelial cell proliferation and network-formation. Hofmann NA, Barth S, Waldeck-Weiermair M, Klec C, Strunk D, Malli R, Graier WF. Biol Open 3 1164-1172 (2014)
  68. An external sodium ion binding site controls allosteric gating in TRPV1 channels. Jara-Oseguera A, Bae C, Swartz KJ. Elife 5 e13356 (2016)
  69. Heat activation is intrinsic to the pore domain of TRPV1. Zhang F, Jara-Oseguera A, Chang TH, Bae C, Hanson SM, Swartz KJ. Proc Natl Acad Sci U S A 115 E317-E324 (2018)
  70. Structural basis for PtdInsP2-mediated human TRPML1 regulation. Fine M, Schmiege P, Li X. Nat Commun 9 4192 (2018)
  71. De Novo modeling in cryo-EM density maps with Pathwalking. Chen M, Baldwin PR, Ludtke SJ, Baker ML. J Struct Biol 196 289-298 (2016)
  72. Engineering vanilloid-sensitivity into the rat TRPV2 channel. Zhang F, Hanson SM, Jara-Oseguera A, Krepkiy D, Bae C, Pearce LV, Blumberg PM, Newstead S, Swartz KJ. Elife 5 e16409 (2016)
  73. Irritant-evoked activation and calcium modulation of the TRPA1 receptor. Zhao J, Lin King JV, Paulsen CE, Cheng Y, Julius D. Nature 585 141-145 (2020)
  74. A Cell-Penetrating Scorpion Toxin Enables Mode-Specific Modulation of TRPA1 and Pain. Lin King JV, Emrick JJ, Kelly MJS, Herzig V, King GF, Medzihradszky KF, Julius D. Cell 178 1362-1374.e16 (2019)
  75. Amphipols outperform dodecylmaltoside micelles in stabilizing membrane protein structure in the gas phase. Calabrese AN, Watkinson TG, Henderson PJ, Radford SE, Ashcroft AE. Anal Chem 87 1118-1126 (2015)
  76. Identification of a putative binding site critical for general anesthetic activation of TRPA1. Ton HT, Phan TX, Abramyan AM, Shi L, Ahern GP. Proc Natl Acad Sci U S A 114 3762-3767 (2017)
  77. Cryo-EM structure of the polycystic kidney disease-like channel PKD2L1. Su Q, Hu F, Liu Y, Ge X, Mei C, Yu S, Shen A, Zhou Q, Yan C, Lei J, Zhang Y, Liu X, Wang T. Nat Commun 9 1192 (2018)
  78. Mutation of I696 and W697 in the TRP box of vanilloid receptor subtype I modulates allosteric channel activation. Gregorio-Teruel L, Valente P, González-Ros JM, Fernández-Ballester G, Ferrer-Montiel A. J Gen Physiol 143 361-375 (2014)
  79. Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel. Suo Y, Wang Z, Zubcevic L, Hsu AL, He Q, Borgnia MJ, Ji RR, Lee SY. Neuron 105 882-894.e5 (2020)
  80. Structural basis for KCNE3 modulation of potassium recycling in epithelia. Kroncke BM, Van Horn WD, Smith J, Kang C, Welch RC, Song Y, Nannemann DP, Taylor KC, Sisco NJ, Sisco NJ, George AL, Meiler J, Vanoye CG, Sanders CR. Sci Adv 2 e1501228 (2016)
  81. Structural determinants of 5',6'-epoxyeicosatrienoic acid binding to and activation of TRPV4 channel. Berna-Erro A, Izquierdo-Serra M, Sepúlveda RV, Rubio-Moscardo F, Doñate-Macián P, Serra SA, Carrillo-Garcia J, Perálvarez-Marín A, González-Nilo F, Fernández-Fernández JM, Valverde MA. Sci Rep 7 10522 (2017)
  82. Structure of the vacuolar H+-ATPase rotary motor reveals new mechanistic insights. Rawson S, Phillips C, Huss M, Tiburcy F, Wieczorek H, Trinick J, Harrison MA, Muench SP. Structure 23 461-471 (2015)
  83. Regulatory switch at the cytoplasmic interface controls TRPV channel gating. Zubcevic L, Borschel WF, Hsu AL, Borgnia MJ, Lee SY. Elife 8 e47746 (2019)
  84. TRPV1 pore turret dictates distinct DkTx and capsaicin gating. Geron M, Kumar R, Zhou W, Faraldo-Gómez JD, Vásquez V, Priel A. Proc Natl Acad Sci U S A 115 E11837-E11846 (2018)
  85. Transient Receptor Potential Vanilloid 1 Regulates Mitochondrial Membrane Potential and Myocardial Reperfusion Injury. Hurt CM, Lu Y, Stary CM, Piplani H, Small BA, Urban TJ, Qvit N, Gross GJ, Mochly-Rosen D, Gross ER. J Am Heart Assoc 5 e003774 (2016)
  86. The pain receptor TRPV1 displays agonist-dependent activation stoichiometry. Hazan A, Kumar R, Matzner H, Priel A. Sci Rep 5 12278 (2015)
  87. Cryo-EM structures of the mammalian endo-lysosomal TRPML1 channel elucidate the combined regulation mechanism. Zhang S, Li N, Zeng W, Gao N, Yang M. Protein Cell 8 834-847 (2017)
  88. Ion Channel Sensing: Are Fluctuations the Crux of the Matter? Kasimova MA, Yazici A, Yudin Y, Granata D, Klein ML, Rohacs T, Carnevale V. J Phys Chem Lett 9 1260-1264 (2018)
  89. Letter Olmsted syndrome with erythromelalgia caused by recessive transient receptor potential vanilloid 3 mutations. Duchatelet S, Guibbal L, de Veer S, Fraitag S, Nitschké P, Zarhrate M, Bodemer C, Hovnanian A. Br J Dermatol 171 675-678 (2014)
  90. Structural basis for activation of voltage sensor domains in an ion channel TPC1. Kintzer AF, Green EM, Dominik PK, Bridges M, Armache JP, Deneka D, Kim SS, Hubbell W, Kossiakoff AA, Cheng Y, Stroud RM. Proc Natl Acad Sci U S A 115 E9095-E9104 (2018)
  91. Structures of TRPV2 in distinct conformations provide insight into role of the pore turret. Dosey TL, Wang Z, Fan G, Zhang Z, Serysheva II, Chiu W, Wensel TG. Nat Struct Mol Biol 26 40-49 (2019)
  92. Unveiling TRPV1 spatio-temporal organization in live cell membranes. Storti B, Di Rienzo C, Cardarelli F, Bizzarri R, Beltram F. PLoS One 10 e0116900 (2015)
  93. Post-Translational Modifications of TRP Channels. Voolstra O, Huber A. Cells 3 258-287 (2014)
  94. Regulation of the temperature-dependent activation of transient receptor potential vanilloid 1 (TRPV1) by phospholipids in planar lipid bilayers. Sun X, Zakharian E. J Biol Chem 290 4741-4747 (2015)
  95. Single-particle electron microscopy in the study of membrane protein structure. De Zorzi R, Mi W, Liao M, Walz T. Microscopy (Oxf) 65 81-96 (2016)
  96. TRPV1 antagonists that cause hypothermia, instead of hyperthermia, in rodents: Compounds' pharmacological profiles, in vivo targets, thermoeffectors recruited and implications for drug development. Garami A, Pakai E, McDonald HA, Reilly RM, Gomtsyan A, Corrigan JJ, Pinter E, Zhu DXD, Lehto SG, Gavva NR, Kym PR, Romanovsky AA. Acta Physiol (Oxf) 223 e13038 (2018)
  97. Targeting the transient receptor potential vanilloid type 1 (TRPV1) assembly domain attenuates inflammation-induced hypersensitivity. Flynn R, Chapman K, Iftinca M, Aboushousha R, Varela D, Altier C. J Biol Chem 289 16675-16687 (2014)
  98. The Integrity of the TRP Domain Is Pivotal for Correct TRPV1 Channel Gating. Gregorio-Teruel L, Valente P, Liu B, Fernández-Ballester G, Qin F, Ferrer-Montiel A. Biophys J 109 529-541 (2015)
  99. Conserved allosteric pathways for activation of TRPV3 revealed through engineering vanilloid-sensitivity. Zhang F, Swartz KJ, Jara-Oseguera A. Elife 8 e42756 (2019)
  100. Nicotinic acid activates the capsaicin receptor TRPV1: Potential mechanism for cutaneous flushing. Ma L, Lee BH, Mao R, Cai A, Jia Y, Clifton H, Schaefer S, Xu L, Zheng J. Arterioscler Thromb Vasc Biol 34 1272-1280 (2014)
  101. Optimization of TRPV6 Calcium Channel Inhibitors Using a 3D Ligand-Based Virtual Screening Method. Simonin C, Awale M, Brand M, van Deursen R, Schwartz J, Fine M, Kovacs G, Häfliger P, Gyimesi G, Sithampari A, Charles RP, Hediger MA, Reymond JL. Angew Chem Int Ed Engl 54 14748-14752 (2015)
  102. Symmetry transitions during gating of the TRPV2 ion channel in lipid membranes. Zubcevic L, Hsu AL, Borgnia MJ, Lee SY. Elife 8 e45779 (2019)
  103. Systematic analysis of the use of amphipathic polymers for studies of outer membrane proteins using mass spectrometry. Watkinson TG, Calabrese AN, Giusti F, Zoonens M, Radford SE, Ashcroft AE. Int J Mass Spectrom 391 54-61 (2015)
  104. Diverse TRPV1 responses to cannabinoids. Starkus J, Jansen C, Shimoda LMN, Stokes AJ, Small-Howard AL, Turner H. Channels (Austin) 13 172-191 (2019)
  105. Expression, purification, and structural insights for the human uric acid transporter, GLUT9, using the Xenopus laevis oocytes system. Clémençon B, Lüscher BP, Fine M, Baumann MU, Surbek DV, Bonny O, Hediger MA. PLoS One 9 e108852 (2014)
  106. Mibefradil represents a new class of benzimidazole TRPM7 channel agonists. Schäfer S, Ferioli S, Hofmann T, Zierler S, Gudermann T, Chubanov V. Pflugers Arch 468 623-634 (2016)
  107. Myrcene and terpene regulation of TRPV1. Jansen C, Shimoda LMN, Kawakami JK, Ang L, Bacani AJ, Baker JD, Badowski C, Speck M, Stokes AJ, Small-Howard AL, Turner H. Channels (Austin) 13 344-366 (2019)
  108. Structural basis of TRPA1 inhibition by HC-030031 utilizing species-specific differences. Gupta R, Saito S, Mori Y, Itoh SG, Okumura H, Tominaga M. Sci Rep 6 37460 (2016)
  109. Identification of significant amino acids in multiple transmembrane domains of human transient receptor potential ankyrin 1 (TRPA1) for activation by eudesmol, an oxygenized sesquiterpene in hop essential oil. Ohara K, Fukuda T, Okada H, Kitao S, Ishida Y, Kato K, Takahashi C, Katayama M, Uchida K, Tominaga M. J Biol Chem 290 3161-3171 (2015)
  110. Mechanism of ligand activation of a eukaryotic cyclic nucleotide-gated channel. Zheng X, Fu Z, Su D, Zhang Y, Li M, Pan Y, Li H, Li S, Grassucci RA, Ren Z, Hu Z, Li X, Zhou M, Li G, Frank J, Yang J. Nat Struct Mol Biol 27 625-634 (2020)
  111. Quantitative Analyses of Synergistic Responses between Cannabidiol and DNA-Damaging Agents on the Proliferation and Viability of Glioblastoma and Neural Progenitor Cells in Culture. Deng L, Ng L, Ozawa T, Stella N. J Pharmacol Exp Ther 360 215-224 (2017)
  112. Comment Structural biology: Ion channel seen by electron microscopy. Henderson R. Nature 504 93-94 (2013)
  113. Critical role of the pore domain in the cold response of TRPM8 channels identified by ortholog functional comparison. Pertusa M, Rivera B, González A, Ugarte G, Madrid R. J Biol Chem 293 12454-12471 (2018)
  114. Detailed Analysis of the Binding Mode of Vanilloids to Transient Receptor Potential Vanilloid Type I (TRPV1) by a Mutational and Computational Study. Ohbuchi K, Mori Y, Ogawa K, Warabi E, Yamamoto M, Hirokawa T. PLoS One 11 e0162543 (2016)
  115. Lys49 myotoxin from the Brazilian lancehead pit viper elicits pain through regulated ATP release. Zhang C, Medzihradszky KF, Sánchez EE, Basbaum AI, Julius D. Proc Natl Acad Sci U S A 114 E2524-E2532 (2017)
  116. Nicotinic acid is a common regulator of heat-sensing TRPV1-4 ion channels. Ma L, Lee BH, Clifton H, Schaefer S, Zheng J. Sci Rep 5 8906 (2015)
  117. Outer membrane protein F stabilised with minimal amphipol forms linear arrays and LPS-dependent 2D crystals. Arunmanee W, Harris JR, Lakey JH. J Membr Biol 247 949-956 (2014)
  118. Selective Activation of Nociceptor TRPV1 Channel and Reversal of Inflammatory Pain in Mice by a Novel Coumarin Derivative Muralatin L from Murraya alata. Wei NN, Lv HN, Wu Y, Yang SL, Sun XY, Lai R, Jiang Y, Wang K. J Biol Chem 291 640-651 (2016)
  119. Silica nanoparticles inhibit the cation channel TRPV4 in airway epithelial cells. Sanchez A, Alvarez JL, Demydenko K, Jung C, Alpizar YA, Alvarez-Collazo J, Cokic SM, Valverde MA, Hoet PH, Talavera K. Part Fibre Toxicol 14 43 (2017)
  120. Structural modeling and patch-clamp analysis of pain-related mutation TRPA1-N855S reveal inter-subunit salt bridges stabilizing the channel open state. Zíma V, Witschas K, Hynkova A, Zímová L, Barvík I, Vlachova V. Neuropharmacology 93 294-307 (2015)
  121. Structural snapshots of TRPV1 reveal mechanism of polymodal functionality. Zhang K, Julius D, Cheng Y. Cell 184 5138-5150.e12 (2021)
  122. TRPV1 temperature activation is specifically sensitive to strong decreases in amino acid hydrophobicity. Sosa-Pagán JO, Iversen ES, Grandl J. Sci Rep 7 549 (2017)
  123. The ion selectivity filter is not an activation gate in TRPV1-3 channels. Jara-Oseguera A, Huffer KE, Swartz KJ. Elife 8 e51212 (2019)
  124. The region adjacent to the C-end of the inner gate in transient receptor potential melastatin 8 (TRPM8) channels plays a central role in allosteric channel activation. Taberner FJ, López-Córdoba A, Fernández-Ballester G, Korchev Y, Ferrer-Montiel A. J Biol Chem 289 28579-28594 (2014)
  125. The structure of lipid nanodisc-reconstituted TRPV3 reveals the gating mechanism. Shimada H, Kusakizako T, Dung Nguyen TH, Nishizawa T, Hino T, Tominaga M, Nureki O. Nat Struct Mol Biol 27 645-652 (2020)
  126. A competing hydrophobic tug on L596 to the membrane core unlatches S4-S5 linker elbow from TRP helix and allows TRPV4 channel to open. Teng J, Loukin SH, Anishkin A, Kung C. Proc Natl Acad Sci U S A 113 11847-11852 (2016)
  127. A molecular determinant of phosphoinositide affinity in mammalian TRPV channels. Velisetty P, Borbiro I, Kasimova MA, Liu L, Badheka D, Carnevale V, Rohacs T. Sci Rep 6 27652 (2016)
  128. Conformational dynamics in TRPV1 channels reported by an encoded coumarin amino acid. Steinberg X, Kasimova MA, Cabezas-Bratesco D, Galpin JD, Ladron-de-Guevara E, Villa F, Carnevale V, Islas L, Ahern CA, Brauchi SE. Elife 6 e28626 (2017)
  129. Different agonists induce distinct single-channel conductance states in TRPV1 channels. Canul-Sánchez JA, Hernández-Araiza I, Hernández-García E, Llorente I, Morales-Lázaro SL, Islas LD, Rosenbaum T. J Gen Physiol 150 1735-1746 (2018)
  130. Intracellular cavity of sensor domain controls allosteric gating of TRPA1 channel. Zimova L, Sinica V, Kadkova A, Vyklicka L, Zima V, Barvik I, Vlachova V. Sci Signal 11 eaan8621 (2018)
  131. Intracellular long-chain acyl CoAs activate TRPV1 channels. Yu Y, Carter CR, Youssef N, Dyck JR, Light PE. PLoS One 9 e96597 (2014)
  132. Lipid Interactions of a Ciliary Membrane TRP Channel: Simulation and Structural Studies of Polycystin-2. Wang Q, Corey RA, Hedger G, Aryal P, Grieben M, Nasrallah C, Baronina A, Pike ACW, Shi J, Carpenter EP, Sansom MSP. Structure 28 169-184.e5 (2020)
  133. Solution behavior and crystallization of cytochrome bc₁ in the presence of amphipols. Charvolin D, Picard M, Huang LS, Berry EA, Popot JL. J Membr Biol 247 981-996 (2014)
  134. Structural mechanism of heat-induced opening of a temperature-sensitive TRP channel. Nadezhdin KD, Neuberger A, Trofimov YA, Krylov NA, Sinica V, Kupko N, Vlachova V, Zakharian E, Efremov RG, Sobolevsky AI. Nat Struct Mol Biol 28 564-572 (2021)
  135. Structural mechanisms underlying activation of TRPV1 channels by pungent compounds in gingers. Yin Y, Dong Y, Vu S, Yang F, Yarov-Yarovoy V, Tian Y, Zheng J. Br J Pharmacol 176 3364-3377 (2019)
  136. Structure of Alcohol Oxidase from Pichia pastoris by Cryo-Electron Microscopy. Vonck J, Parcej DN, Mills DJ. PLoS One 11 e0159476 (2016)
  137. 4-Hydroxynonenal dependent alteration of TRPV1-mediated coronary microvascular signaling. DelloStritto DJ, Sinharoy P, Connell PJ, Fahmy JN, Cappelli HC, Thodeti CK, Geldenhuys WJ, Damron DS, Bratz IN. Free Radic Biol Med 101 10-19 (2016)
  138. Decrypting the Heat Activation Mechanism of TRPV1 Channel by Molecular Dynamics Simulation. Wen H, Zheng W. Biophys J 114 40-52 (2018)
  139. Involvement of acid-sensing ion channel 1a in matrix metabolism of endplate chondrocytes under extracellular acidic conditions through NF-κB transcriptional activity. Yuan FL, Zhao MD, Jiang DL, Jin C, Liu HF, Xu MH, Hu W, Li X. Cell Stress Chaperones 21 97-104 (2016)
  140. Molecular mechanism of the tree shrew's insensitivity to spiciness. Han Y, Li B, Yin TT, Xu C, Ombati R, Luo L, Xia Y, Xu L, Zheng J, Zhang Y, Yang F, Wang GD, Yang S, Lai R. PLoS Biol 16 e2004921 (2018)
  141. Multi-Functional Diarylurea Small Molecule Inhibitors of TRPV1 with Therapeutic Potential for Neuroinflammation. Feng Z, Pearce LV, Zhang Y, Xing C, Herold BK, Ma S, Hu Z, Turcios NA, Yang P, Tong Q, McCall AK, Blumberg PM, Xie XQ. AAPS J 18 898-913 (2016)
  142. Near-atomic resolution reconstructions using a mid-range electron microscope operated at 200 kV. Campbell MG, Kearney BM, Cheng A, Potter CS, Johnson JE, Carragher B, Veesler D. J Struct Biol 188 183-187 (2014)
  143. Structural Basis of TRPV4 N Terminus Interaction with Syndapin/PACSIN1-3 and PIP2. Goretzki B, Glogowski NA, Diehl E, Duchardt-Ferner E, Hacker C, Gaudet R, Hellmich UA. Structure 26 1583-1593.e5 (2018)
  144. A Selectivity Filter Gate Controls Voltage-Gated Calcium Channel Calcium-Dependent Inactivation. Abderemane-Ali F, Findeisen F, Rossen ND, Minor DL. Neuron 101 1134-1149.e3 (2019)
  145. Binding Efficacy and Thermogenic Efficiency of Pungent and Nonpungent Analogs of Capsaicin. Baskaran P, Covington K, Bennis J, Mohandass A, Lehmann T, Thyagarajan B. Molecules 23 E3198 (2018)
  146. Calcium Channelopathies: Structural Insights into Disorders of the Muscle Excitation-Contraction Complex. Pancaroglu R, Van Petegem F. Annu Rev Genet 52 373-396 (2018)
  147. Implications of Human Transient Receptor Potential Melastatin 8 (TRPM8) Channel Gating from Menthol Binding Studies of the Sensing Domain. Rath P, Hilton JK, Sisco NJ, Van Horn WD. Biochemistry 55 114-124 (2016)
  148. Molecular Modeling of the Structural and Dynamical Changes in Calcium Channel TRPV5 Induced by the African-Specific A563T Variation. Wang L, Holmes RP, Peng JB. Biochemistry 55 1254-1264 (2016)
  149. Patterns of coevolving amino acids unveil structural and dynamical domains. Granata D, Ponzoni L, Micheletti C, Carnevale V. Proc Natl Acad Sci U S A 114 E10612-E10621 (2017)
  150. Pirt contributes to uterine contraction-induced pain in mice. Wang C, Wang Z, Yang Y, Zhu C, Wu G, Yu G, Jian T, Yang N, Shi H, Tang M, He Q, Lan L, Liu Q, Guan Y, Dong X, Duan J, Tang Z. Mol Pain 11 57 (2015)
  151. Pore dilation reconsidered. Bean BP. Nat Neurosci 18 1534-1535 (2015)
  152. Single-particle cryo-EM of the ryanodine receptor channel in an aqueous environment. Baker MR, Fan G, Serysheva II. Eur J Transl Myol 25 35-48 (2015)
  153. Structural Refinement of Proteins by Restrained Molecular Dynamics Simulations with Non-interacting Molecular Fragments. Shen R, Han W, Fiorin G, Islam SM, Schulten K, Roux B. PLoS Comput Biol 11 e1004368 (2015)
  154. Synthetic and Biological Studies of Sesquiterpene Polygodial: Activity of 9-Epipolygodial against Drug-Resistant Cancer Cells. Dasari R, De Carvalho A, Medellin DC, Middleton KN, Hague F, Volmar MN, Frolova LV, Rossato MF, De La Chapa JJ, Dybdal-Hargreaves NF, Pillai A, Mathieu V, Rogelj S, Gonzales CB, Calixto JB, Evidente A, Gautier M, Munirathinam G, Glass R, Burth P, Pelly SC, van Otterlo WA, Kiss R, Kornienko A. ChemMedChem 10 2014-2026 (2015)
  155. TRPV1 expressed throughout the arterial circulation regulates vasoconstriction and blood pressure. Phan TX, Ton HT, Gulyás H, Pórszász R, Tóth A, Russo R, Kay MW, Sahibzada N, Ahern GP. J Physiol 598 5639-5659 (2020)
  156. Thermodynamic implications of high Q 10 of thermo-TRP channels in living cells. Ito E, Ikemoto Y, Yoshioka T. Biophysics (Nagoya-shi) 11 33-38 (2015)
  157. Transient receptor potential channels: current perspectives on evolution, structure, function and nomenclature. Himmel NJ, Cox DN. Proc Biol Sci 287 20201309 (2020)
  158. Transient receptor potential vanilloid 4 (TRPV4) channel as a target of crotamiton and its bimodal effects. Kittaka H, Yamanoi Y, Tominaga M. Pflugers Arch 469 1313-1323 (2017)
  159. An Unorthodox Mechanism Underlying Voltage Sensitivity of TRPV1 Ion Channel. Yang F, Xu L, Lee BH, Xiao X, Yarov-Yarovoy V, Zheng J. Adv Sci (Weinh) 7 2000575 (2020)
  160. Evidence for Novel Pharmacological Sensitivities of Transient Receptor Potential (TRP) Channels in Schistosoma mansoni. Bais S, Churgin MA, Fang-Yen C, Greenberg RM. PLoS Negl Trop Dis 9 e0004295 (2015)
  161. Expression of TRPV1 channels by Cajal-Retzius cells and layer-specific modulation of synaptic transmission by capsaicin in the mouse hippocampus. Anstötz M, Lee SK, Maccaferri G. J Physiol 596 3739-3758 (2018)
  162. Heterologously-expressed and Liposome-reconstituted Human Transient Receptor Potential Melastatin 4 Channel (TRPM4) is a Functional Tetramer. Constantine M, Liew CK, Lo V, Macmillan A, Cranfield CG, Sunde M, Whan R, Graham RM, Martinac B. Sci Rep 6 19352 (2016)
  163. Lactate is a potent inhibitor of the capsaicin receptor TRPV1. de la Roche J, Walther I, Leonow W, Hage A, Eberhardt M, Fischer M, Reeh PW, Sauer S, Leffler A. Sci Rep 6 36740 (2016)
  164. Mitogen-Activated Protein Kinase and Intracellular Polyamine Signaling Is Involved in TRPV1 Activation-Induced Cardiac Hypertrophy. Chen M, Xin J, Liu B, Luo L, Li J, Yin W, Li M. J Am Heart Assoc 5 e003718 (2016)
  165. Molecular mechanisms underlying menthol binding and activation of TRPM8 ion channel. Xu L, Han Y, Chen X, Aierken A, Wen H, Zheng W, Wang H, Lu X, Zhao Z, Ma C, Liang P, Yang W, Yang S, Yang F. Nat Commun 11 3790 (2020)
  166. Preferential selection of Arginine at the lipid-water-interface of TRPV1 during vertebrate evolution correlates with its snorkeling behaviour and cholesterol interaction. Saha S, Ghosh A, Ghosh A, Tiwari N, Kumar A, Kumar A, Goswami C. Sci Rep 7 16808 (2017)
  167. Structural and Evolutionary Insights Point to Allosteric Regulation of TRP Ion Channels. Hilton JK, Kim M, Van Horn WD. Acc Chem Res 52 1643-1652 (2019)
  168. Structure of the Cellulose Synthase Complex of Gluconacetobacter hansenii at 23.4 Å Resolution. Du J, Vepachedu V, Cho SH, Kumar M, Nixon BT. PLoS One 11 e0155886 (2016)
  169. Synthetic Analogues of the Snail Toxin 6-Bromo-2-mercaptotryptamine Dimer (BrMT) Reveal That Lipid Bilayer Perturbation Does Not Underlie Its Modulation of Voltage-Gated Potassium Channels. Dockendorff C, Gandhi DM, Kimball IH, Eum KS, Rusinova R, Ingólfsson HI, Kapoor R, Peyear T, Dodge MW, Martin SF, Aldrich RW, Andersen OS, Sack JT. Biochemistry 57 2733-2743 (2018)
  170. TRPV channel-mediated calcium transients in nociceptor neurons are dispensable for avoidance behaviour. Lindy AS, Parekh PK, Zhu R, Kanju P, Chintapalli SV, Tsvilovskyy V, Patterson RL, Anishkin A, van Rossum DB, Liedtke WB. Nat Commun 5 4734 (2014)
  171. TRPV1 ligands with hyperthermic, hypothermic and no temperature effects in rats. Gomtsyan A, McDonald HA, Schmidt RG, Daanen JF, Voight EA, Segreti JA, Puttfarcken PS, Reilly RM, Kort ME, Dart MJ, Kym PR. Temperature (Austin) 2 297-301 (2015)
  172. Tyrosine Residue in the TRPV1 Vanilloid Binding Pocket Regulates Deactivation Kinetics. Kumar R, Hazan A, Basu A, Zalcman N, Matzner H, Priel A. J Biol Chem 291 13855-13863 (2016)
  173. Wittig derivatization of sesquiterpenoid polygodial leads to cytostatic agents with activity against drug resistant cancer cells and capable of pyrrolylation of primary amines. Dasari R, De Carvalho A, Medellin DC, Middleton KN, Hague F, Volmar MN, Frolova LV, Rossato MF, De La Chapa JJ, Dybdal-Hargreaves NF, Pillai A, Kälin RE, Mathieu V, Rogelj S, Gonzales CB, Calixto JB, Evidente A, Gautier M, Munirathinam G, Glass R, Burth P, Pelly SC, van Otterlo WA, Kiss R, Kornienko A. Eur J Med Chem 103 226-237 (2015)
  174. A single TRPV1 amino acid controls species sensitivity to capsaicin. Chu Y, Cohen BE, Chuang HH. Sci Rep 10 8038 (2020)
  175. An insight into paracetamol and its metabolites using molecular docking and molecular dynamics simulation. Wang Y, Lin W, Wu N, He X, Wang J, Feng Z, Xie XQ. J Mol Model 24 243 (2018)
  176. Biochemical and structural analysis of the hyperpolarization-activated K(+) channel MVP. Randich AM, Cuello LG, Wanderling SS, Perozo E. Biochemistry 53 1627-1636 (2014)
  177. Discovery of N-(3-fluoro-4-methylsulfonamidomethylphenyl)urea as a potent TRPV1 antagonistic template. Ann J, Sun W, Zhou X, Jung A, Baek J, Lee S, Kim C, Yoon S, Hong S, Choi S, Turcios NA, Herold BK, Esch TE, Lewin NE, Abramovitz A, Pearce LV, Blumberg PM, Lee J. Bioorg Med Chem Lett 26 3603-3607 (2016)
  178. Exploring functional roles of TRPV1 intracellular domains with unstructured peptide-insertion screening. Ma L, Yang F, Vu S, Zheng J. Sci Rep 6 33827 (2016)
  179. Local Ca2+ signals couple activation of TRPV1 and ANO1 sensory ion channels. Shah S, Carver CM, Mullen P, Milne S, Lukacs V, Shapiro MS, Gamper N. Sci Signal 13 eaaw7963 (2020)
  180. Novel scaffolds for modulation of TRPV1 identified with pharmacophore modeling and virtual screening. Goldmann D, Pakfeifer P, Hering S, Ecker GF. Future Med Chem 7 243-256 (2015)
  181. Pirt Together with TRPV1 Is Involved in the Regulation of Neuropathic Pain. Wang C, Gu L, Ruan Y, Gegen T, Yu L, Zhu C, Yang Y, Zhou Y, Yu G, Tang Z. Neural Plast 2018 4861491 (2018)
  182. The molecular pathway of ATP-sensitive potassium channel in endothelial cells for mediating arteriole relaxation. Chen X, Han W, Zhang Y, Cui W, Pan Z, Jin X, Long C, Wang H. Life Sci 137 164-169 (2015)
  183. Thermal melt circular dichroism spectroscopic studies for identifying stabilising amphipathic molecules for the voltage-gated sodium channel NavMs. Ireland SM, Sula A, Wallace BA. Biopolymers 109 e23067 (2018)
  184. Visualization by high resolution immunoelectron microscopy of the transient receptor potential vanilloid-1 at inhibitory synapses of the mouse dentate gyrus. Canduela MJ, Mendizabal-Zubiaga J, Puente N, Reguero L, Elezgarai I, Ramos-Uriarte A, Gerrikagoitia I, Grandes P. PLoS One 10 e0119401 (2015)
  185. A conserved gating element in TRPV6 channels. Hofmann L, Wang H, Beck A, Wissenbach U, Flockerzi V. Cell Calcium 63 24-28 (2017)
  186. A multiscale model of mechanotransduction by the ankyrin chains of the NOMPC channel. Argudo D, Capponi S, Bethel NP, Grabe M. J Gen Physiol 151 316-327 (2019)
  187. Determining the molecular basis of voltage sensitivity in membrane proteins. Kasimova MA, Lindahl E, Delemotte L. J Gen Physiol 150 1444-1458 (2018)
  188. Extracellular cap domain is an essential component of the TRPV1 gating mechanism. Nadezhdin KD, Neuberger A, Nikolaev YA, Murphy LA, Gracheva EO, Bagriantsev SN, Sobolevsky AI. Nat Commun 12 2154 (2021)
  189. Insect TRP channels as targets for insecticides and repellents. Salgado VL. J Pestic Sci 42 1-6 (2017)
  190. Requirement of extracellular Ca2+ binding to specific amino acids for heat-evoked activation of TRPA1. Kurganov E, Saito S, Tanaka Saito C, Tominaga M. J Physiol 595 2451-2463 (2017)
  191. Spicy science: David Julius and the discovery of temperature-sensitive TRP channels. Bautista DM. Temperature (Austin) 2 135-141 (2015)
  192. TRPA1 modulation by piperidine carboxamides suggests an evolutionarily conserved binding site and gating mechanism. Chernov-Rogan T, Gianti E, Liu C, Villemure E, Cridland AP, Hu X, Ballini E, Lange W, Deisemann H, Li T, Ward SI, Hackos DH, Magnuson S, Safina B, Klein ML, Volgraf M, Carnevale V, Chen J. Proc Natl Acad Sci U S A 116 26008-26019 (2019)
  193. "TRPV1 is a component of the atrial natriuretic signaling complex, and using orally delivered antagonists, presents a valid therapeutic target in the longitudinal reversal and treatment of cardiac hypertrophy and heart failure". Horton JS, Shiraishi T, Alfulaij N, Small-Howard AL, Turner HC, Kurokawa T, Mori Y, Stokes AJ. Channels (Austin) 13 1-16 (2019)
  194. Charge Neutralization Drives the Shape Reconfiguration of DNA Nanotubes. Liu P, Zhao Y, Liu X, Sun J, Xu D, Li Y, Li Q, Wang L, Yang S, Fan C, Lin J. Angew Chem Int Ed Engl 57 5418-5422 (2018)
  195. Different ligands of the TRPV3 cation channel cause distinct conformational changes as revealed by intrinsic tryptophan fluorescence quenching. Billen B, Brams M, Debaveye S, Remeeva A, Alpizar YA, Waelkens E, Kreir M, Brüggemann A, Talavera K, Nilius B, Voets T, Ulens C. J Biol Chem 290 12964-12974 (2015)
  196. Endocannabinoid activation of the TRPV1 ion channel is distinct from activation by capsaicin. Li Y, Chen X, Nie Y, Tian Y, Xiao X, Yang F. J Biol Chem 297 101022 (2021)
  197. Evidence for Mechanosensitive Channel Activity of Tentonin 3/TMEM150C. Hong GS, Lee B, Oh U. Neuron 94 271-273.e2 (2017)
  198. Expression and Purification of the Pain Receptor TRPV1 for Spectroscopic Analysis. Velisetty P, Stein RA, Sierra-Valdez FJ, Vásquez V, Cordero-Morales JF. Sci Rep 7 9861 (2017)
  199. Heterologous calcium-dependent inactivation of Orai1 by neighboring TRPV1 channels modulates cell migration and wound healing. Bastián-Eugenio CE, Bohórquez-Hernández A, Pacheco J, Sampieri A, Asanov A, Ocelotl-Oviedo JP, Guerrero A, Darszon A, Vaca L. Commun Biol 2 88 (2019)
  200. Intracellular spermine blocks TRPC4 channel via electrostatic interaction with C-terminal negative amino acids. Kim J, Moon SH, Shin YC, Jeon JH, Park KJ, Lee KP, So I. Pflugers Arch 468 551-561 (2016)
  201. Mapping the neuroethological signatures of pain, analgesia, and recovery in mice. Bohic M, Pattison LA, Jhumka ZA, Rossi H, Thackray JK, Ricci M, Mossazghi N, Foster W, Ogundare S, Twomey CR, Hilton H, Arnold J, Tischfield MA, Yttri EA, St John Smith E, Abdus-Saboor I, Abraira VE. Neuron 111 2811-2830.e8 (2023)
  202. Molecular determinants for agonist recognition and discrimination in P2X2 receptors. Gasparri F, Wengel J, Grutter T, Pless SA. J Gen Physiol 151 898-911 (2019)
  203. Proximal C-Terminus Serves as a Signaling Hub for TRPA1 Channel Regulation via Its Interacting Molecules and Supramolecular Complexes. Zimova L, Barvikova K, Macikova L, Vyklicka L, Sinica V, Barvik I, Vlachova V. Front Physiol 11 189 (2020)
  204. Quantitative optical lock-in detection for quantitative imaging of switchable and non-switchable components. Abbandonato G, Storti B, Signore G, Beltram F, Bizzarri R. Microsc Res Tech 79 929-937 (2016)
  205. Single-particle cryoEM analysis at near-atomic resolution from several thousand asymmetric subunits. Passos DO, Lyumkis D. J Struct Biol 192 235-244 (2015)
  206. Studying Structural Dynamics of Potassium Channels by Single-Molecule FRET. Wang S, Brettmann JB, Nichols CG. Methods Mol Biol 1684 163-180 (2018)
  207. TRPV1 channel as a target for cancer therapy using CNT-based drug delivery systems. Ortega-Guerrero A, Espinosa-Duran JM, Velasco-Medina J. Eur Biophys J 45 423-433 (2016)
  208. The Pore Loop Domain of TRPV1 Is Required for Its Activation by the Volatile Anesthetics Chloroform and Isoflurane. Kimball C, Luo J, Yin S, Hu H, Dhaka A. Mol Pharmacol 88 131-138 (2015)
  209. Transient receptor potential channels in pulmonary chemical injuries and as countermeasure targets. Achanta S, Jordt SE. Ann N Y Acad Sci 1480 73-103 (2020)
  210. 2-Sulfonamidopyridine C-region analogs of 2-(3-fluoro-4-methylsulfonamidophenyl)propanamides as potent TRPV1 antagonists. Ann J, Ki Y, Yoon S, Kim MS, Lee JU, Kim C, Lee S, Jung A, Baek J, Hong S, Choi S, Pearce LV, Esch TE, Turcios NA, Lewin NE, Ogunjirin AE, Herold BK, McCall AK, Blumberg PM, Lee J. Bioorg Med Chem 24 1231-1240 (2016)
  211. A novel tarantula toxin stabilizes the deactivated voltage sensor of bacterial sodium channel. Tang C, Zhou X, Nguyen PT, Zhang Y, Hu Z, Zhang C, Yarov-Yarovoy V, DeCaen PG, Liang S, Liu Z. FASEB J 31 3167-3178 (2017)
  212. Antinociceptive effect of natural and synthetic alkamides involves TRPV1 receptors. de la Rosa-Lugo V, Acevedo-Quiroz M, Déciga-Campos M, Rios MY. J Pharm Pharmacol 69 884-895 (2017)
  213. Cytoplasmic Inter-Subunit Interface Controls Use-Dependence of Thermal Activation of TRPV3 Channel. Macikova L, Vyklicka L, Barvik I, Sobolevsky AI, Vlachova V. Int J Mol Sci 20 E3990 (2019)
  214. Discovering of Tumor-targeting Peptides using Bi-functional Microarray. Wang W, Wang Z, Bu X, Li R, Zhou M, Hu Z. Adv Healthc Mater 4 2802-2808 (2015)
  215. Heat-dependent opening of TRPV1 in the presence of capsaicin. Kwon DH, Zhang F, Suo Y, Bouvette J, Borgnia MJ, Lee SY. Nat Struct Mol Biol 28 554-563 (2021)
  216. Ion channel-mediated uptake of cationic vital dyes into live cells: a potential source of error when assessing cell viability. Bukhari M, Burm H, Samways DS. Cell Biol Toxicol 32 363-371 (2016)
  217. Isoform-specific modulation of the chemical sensitivity of conserved TRPA1 channel in the major honeybee ectoparasitic mite, Tropilaelaps mercedesae. Dong X, Kashio M, Peng G, Wang X, Tominaga M, Kadowaki T. Open Biol 6 160042 (2016)
  218. Structural basis for human TRPC5 channel inhibition by two distinct inhibitors. Song K, Wei M, Guo W, Quan L, Kang Y, Wu JX, Chen L. Elife 10 e63429 (2021)
  219. Structural determinants of TRPV4 inhibition and identification of new antagonists with antiviral activity. Doñate-Macian P, Duarte Y, Rubio-Moscardo F, Pérez-Vilaró G, Canan J, Díez J, González-Nilo F, Valverde MA. Br J Pharmacol 179 3576-3591 (2022)
  220. TRPV1 channel modulation by hyaluronan reduces pain. de la Peña E, Gomis A, Ferrer-Montiel A, Belmonte C. Channels (Austin) 10 81-82 (2016)
  221. TRPV1 variants impair intracellular Ca2+ signaling and may confer susceptibility to malignant hyperthermia. Vanden Abeele F, Lotteau S, Ducreux S, Dubois C, Monnier N, Hanna A, Gkika D, Romestaing C, Noyer L, Flourakis M, Tessier N, Al-Mawla R, Chouabe C, Lefai E, Lunardi J, Hamilton S, Fauré J, Van Coppenolle F, Prevarskaya N. Genet Med 21 441-450 (2019)
  222. The Contribution of the Ankyrin Repeat Domain of TRPV1 as a Thermal Module. Ladrón-de-Guevara E, Dominguez L, Rangel-Yescas GE, Fernández-Velasco DA, Torres-Larios A, Rosenbaum T, Islas LD. Biophys J 118 836-845 (2020)
  223. The push-to-open mechanism of the tethered mechanosensitive ion channel NompC. Wang Y, Guo Y, Li G, Liu C, Wang L, Zhang A, Yan Z, Song C. Elife 10 e58388 (2021)
  224. Uncovering a possible role of reactive oxygen species in magnetogenetics. Brier MI, Mundell JW, Yu X, Su L, Holmann A, Squeri J, Zhang B, Stanley SA, Friedman JM, Dordick JS. Sci Rep 10 13096 (2020)
  225. Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP2. Yin Y, Zhang F, Feng S, Butay KJ, Borgnia MJ, Im W, Lee SY. Science 378 eadd1268 (2022)
  226. Analgesic transient receptor potential vanilloid-1-active compounds inhibit native and recombinant T-type calcium channels. McArthur JR, Finol-Urdaneta RK, Adams DJ. Br J Pharmacol 176 2264-2278 (2019)
  227. Atomic insights into ML-SI3 mediated human TRPML1 inhibition. Schmiege P, Fine M, Li X. Structure 29 1295-1302.e3 (2021)
  228. Characterization of Membrane Patch-Ion Channel Probes for Scanning Ion Conductance Microscopy. Shi W, Zeng Y, Zhu C, Xiao Y, Cummins TR, Hou J, Baker LA. Small 14 e1702945 (2018)
  229. Cryo-electron microscopy structure of a human PRMT5:MEP50 complex. Timm DE, Bowman V, Madsen R, Rauch C. PLoS One 13 e0193205 (2018)
  230. Design, synthesis, and in silico studies of novel eugenyloxy propanol azole derivatives having potent antinociceptive activity and evaluation of their β-adrenoceptor blocking property. Behrouz S, Soltani Rad MN, Taghavi Shahraki B, Fathalipour M, Behrouz M, Mirkhani H. Mol Divers 23 147-164 (2019)
  231. Evidence that the TRPV1 S1-S4 membrane domain contributes to thermosensing. Kim M, Sisco NJ, Hilton JK, Montano CM, Castro MA, Cherry BR, Levitus M, Van Horn WD. Nat Commun 11 4169 (2020)
  232. Inactivation-mimicking block of the epithelial calcium channel TRPV6. Bhardwaj R, Lindinger S, Neuberger A, Nadezhdin KD, Singh AK, Cunha MR, Derler I, Gyimesi G, Reymond JL, Hediger MA, Romanin C, Sobolevsky AI. Sci Adv 6 eabe1508 (2020)
  233. Light-coupled cryo-plunger for time-resolved cryo-EM. Yoder N, Jalali-Yazdi F, Noreng S, Houser A, Baconguis I, Gouaux E. J Struct Biol 212 107624 (2020)
  234. Multimerization of Homo sapiens TRPA1 ion channel cytoplasmic domains. Martinez GQ, Gordon SE. PLoS One 14 e0207835 (2019)
  235. Nociception and pain in humans lacking a functional TRPV1 channel. Katz B, Zaguri R, Edvardson S, Maayan C, Elpeleg O, Lev S, Davidson E, Peters M, Kfir-Erenfeld S, Berger E, Ghazalin S, Binshtok AM, Minke B. J Clin Invest 133 e153558 (2023)
  236. Side chain flexibility and coupling between the S4-S5 linker and the TRP domain in thermo-sensitive TRP channels: Insights from protein modeling. Romero-Romero S, Gomez Lagunas F, Balleza D. Proteins 85 630-646 (2017)
  237. Structural basis for promiscuous action of monoterpenes on TRP channels. Nguyen THD, Itoh SG, Okumura H, Tominaga M. Commun Biol 4 293 (2021)
  238. Structural biology: Pain-sensing TRPA1 channel resolved. Clapham DE. Nature 520 439-441 (2015)
  239. Structure of the ancient TRPY1 channel from Saccharomyces cerevisiae reveals mechanisms of modulation by lipids and calcium. Ahmed T, Nisler CR, Fluck EC, Walujkar S, Sotomayor M, Moiseenkova-Bell VY. Structure 30 139-155.e5 (2022)
  240. TRPA1 Channels in Drosophila and Honey Bee Ectoparasitic Mites Share Heat Sensitivity and Temperature-Related Physiological Functions. Peng G, Kashio M, Li T, Dong X, Tominaga M, Kadowaki T. Front Physiol 7 447 (2016)
  241. TRPM channels come into focus. Bae C, Jara-Oseguera A, Swartz KJ. Science 359 160-161 (2018)
  242. A Molecular Basis for the Inhibition of Transient Receptor Potential Vanilloid Type 1 by Gomisin A. Lee SB, Noh S, Yeom HD, Jo H, Eom S, Kim YS, Nam S, Bae H, Lee JH. Evid Based Complement Alternat Med 2017 6451905 (2017)
  243. A folding reaction at the C-terminal domain drives temperature sensing in TRPM8 channels. Díaz-Franulic I, Raddatz N, Castillo K, González-Nilo FD, Latorre R. Proc Natl Acad Sci U S A 117 20298-20304 (2020)
  244. Confined Dynamics of Water in Transmembrane Pore of TRPV1 Ion Channel. Trofimov YA, Krylov NA, Efremov RG. Int J Mol Sci 20 E4285 (2019)
  245. Cryo Electron Microscopy of TRP Channels. Samanta A, Hughes TET, Moiseenkova-Bell VY. Methods Mol Biol 1987 39-50 (2019)
  246. De Novo Design of Peptidic Positive Allosteric Modulators Targeting TRPV1 with Analgesic Effects. Xu L, Zhang H, Wang Y, Lu X, Zhao Z, Ma C, Yang S, Yarov-Yarovoy V, Tian Y, Zheng J, Yang F. Adv Sci (Weinh) 8 e2101716 (2021)
  247. Deficiency of Inositol Monophosphatase Activity Decreases Phosphoinositide Lipids and Enhances TRPV1 Function In Vivo. Caires R, Bell B, Lee J, Romero LO, Vásquez V, Cordero-Morales JF. J Neurosci 41 408-423 (2021)
  248. Determining the amphipol distribution within membrane-protein fibre samples using small-angle neutron scattering. Arunmanee W, Heenan RK, Lakey JH. Acta Crystallogr D Struct Biol 74 1192-1199 (2018)
  249. Dual regulation of TRPV1 channels by phosphatidylinositol via functionally distinct binding sites. Yazici AT, Gianti E, Kasimova MA, Lee BH, Carnevale V, Rohacs T. J Biol Chem 296 100573 (2021)
  250. How do you feel? A warm and touching 2021 Nobel tribute. Caterina MJ. J Clin Invest 131 e156587 (2021)
  251. Mechanosensitive Ion Channels in Cardiovascular Physiology. Teng J, Loukin S, Kung C. Exp Clin Cardiol 20 6550-6560 (2014)
  252. Mechanosensitive ion channels in cell migration. Canales Coutiño B, Mayor R. Cells Dev 166 203683 (2021)
  253. Novobiocin, a Newly Found TRPV1 Inhibitor, Attenuates the Expression of TRPV1 in Rat Intestine and Intestinal Epithelial Cell Line IEC-6. Liang Q, Lv X, Cai Q, Cai Y, Zhao B, Li G. Front Pharmacol 9 1171 (2018)
  254. Structural mechanisms of TRPV6 inhibition by ruthenium red and econazole. Neuberger A, Nadezhdin KD, Sobolevsky AI. Nat Commun 12 6284 (2021)
  255. Temperature oscillations drive cycles in the activity of MMP-2,9 secreted by a human trabecular meshwork cell line. Li SK, Banerjee J, Jang C, Sehgal A, Stone RA, Civan MM. Invest Ophthalmol Vis Sci 56 1396-1405 (2015)
  256. Editorial The hills and valleys of calcium signaling. Zhu MX, Tuo B, Yang JJ. Sci China Life Sci 59 743-748 (2016)
  257. Three multi-allelic gene pairs are responsible for self-sterility in the ascidian Ciona intestinalis. Sawada H, Yamamoto K, Yamaguchi A, Yamada L, Higuchi A, Nukaya H, Fukuoka M, Sakuma T, Yamamoto T, Sasakura Y, Shirae-Kurabayashi M. Sci Rep 10 2514 (2020)
  258. Tyrosine Residues from the S4-S5 Linker of Kv11.1 Channels Are Critical for Slow Deactivation. Ng CA, Gravel AE, Perry MD, Arnold AA, Marcotte I, Vandenberg JI. J Biol Chem 291 17293-17302 (2016)
  259. A Family of Auxiliary Subunits of the TRP Cation Channel Encoded by the Complex inaF Locus. Chen Z, Montell C. Genetics 215 713-728 (2020)
  260. A Potential Route of Capsaicin to Its Binding Site in the TRPV1 Ion Channel. Domene C, Darré L, Oakes V, Gonzalez-Resines S. J Chem Inf Model 62 2481-2489 (2022)
  261. Antioxidative and Analgesic Effects of Naringin through Selective Inhibition of Transient Receptor Potential Vanilloid Member 1. Eom S, Lee BB, Lee S, Park Y, Yeom HD, Kim TH, Nam SH, Lee JH. Antioxidants (Basel) 11 64 (2021)
  262. Applications of Cryo-EM in small molecule and biologics drug design. Lees JA, Dias JM, Han S. Biochem Soc Trans 49 2627-2638 (2021)
  263. Combination of a Rapidly Penetrating Agonist and a Slowly Penetrating Antagonist Affords Agonist Action of Limited Duration at the Cellular Level. Pearce LV, Ann J, Blumberg PM, Lee J. Biomol Ther (Seoul) 27 435-441 (2019)
  264. Comparative Analysis of Single-Molecule Dynamics of TRPV1 and TRPV4 Channels in Living Cells. Kuwashima Y, Yanagawa M, Abe M, Hiroshima M, Ueda M, Arita M, Sako Y. Int J Mol Sci 22 8473 (2021)
  265. Data-driven determination of number of discrete conformations in single-particle cryo-EM. Zhou Y, Moscovich A, Bartesaghi A. Comput Methods Programs Biomed 221 106892 (2022)
  266. Divining the design principles of voltage sensors. Toombes GE, Swartz KJ. J Gen Physiol 143 139-144 (2014)
  267. Endogenous and Exogenous Vanilloids Evoke Disparate TRPV1 Activation to Produce Distinct Neuronal Responses. Kumar R, Geron M, Hazan A, Priel A. Front Pharmacol 11 903 (2020)
  268. Evidence for a phenotypic switch in corneal afferents after lacrimal gland excision. Sullivan C, Lee J, Bushey W, Demers D, Dinsdale S, Lowe K, Olmeda J, Meng ID. Exp Eye Res 218 109005 (2022)
  269. General flexible nature of the cytosolic regions of fungal transient receptor potential (TRP) channels, revealed by expression screening using GFP-fusion techniques. Ihara M, Takano Y, Yamashita A. Protein Sci 23 923-931 (2014)
  270. Identification of a Partial and Selective TRPV1 Agonist CPIPC for Alleviation of Inflammatory Pain. Dong L, Zhou Q, Liang Q, Qiao Z, Liu Y, Shao L, Wang K. Molecules 27 5428 (2022)
  271. Identification of a single aspartate residue critical for both fast and slow calcium-dependent inactivation of the human TRPML1 channel. Wu G, Yang X, Shen Y. J Biol Chem 293 11736-11745 (2018)
  272. Inhibition of Ligand-Gated TRPA1 by General Anesthetics. Ton HT, Phan TX, Ahern GP. Mol Pharmacol 98 185-191 (2020)
  273. Kainic Acid Activates TRPV1 via a Phospholipase C/PIP2-Dependent Mechanism in Vitro. Mohandass A, Surenkhuu B, Covington K, Baskaran P, Lehmann T, Thyagarajan B. ACS Chem Neurosci 11 2999-3007 (2020)
  274. Mapping temperature-dependent conformational change in the voltage-sensing domain of an engineered heat-activated K+ channel. Chen H, Deng J, Cui Q, Chanda B, Henzler-Wildman K. Proc Natl Acad Sci U S A 118 e2017280118 (2021)
  275. Mechanisms and significance of Ca2+ entry through TRPC channels. Bacsa B, Tiapko O, Stockner T, Groschner K. Curr Opin Physiol 17 25-33 (2020)
  276. Modulation of TRPV2 by endogenous and exogenous ligands: A computational study. Feng S, Pumroy RA, Protopopova AD, Moiseenkova-Bell VY, Im W. Protein Sci 32 e4490 (2023)
  277. Molecular basis for the sensitivity of TRP channels to polyunsaturated fatty acids. Riehle M, Tsvetkov D, Gohlke BO, Preissner R, Harteneck C, Gollasch M, Nürnberg B. Naunyn Schmiedebergs Arch Pharmacol 391 833-846 (2018)
  278. Neurogenic substance P-influences on action potential production in afferent neurons of the kidney? Rodionova K, Hilgers KF, Linz P, Schätzl J, Raschke G, Ott C, Schmieder RE, Schiffer M, Amann K, Veelken R, Ditting T. Pflugers Arch 473 633-646 (2021)
  279. New capsaicin analogs as molecular rulers to define the permissive conformation of the mouse TRPV1 ligand-binding pocket. Vu S, Singh V, Wulff H, Yarov-Yarovoy V, Zheng J. Elife 9 e62039 (2020)
  280. Opening of capsaicin receptor TRPV1 is stabilized equally by its four subunits. Li S, Nguyen PT, Vu S, Yarov-Yarovoy V, Zheng J. J Biol Chem 299 104828 (2023)
  281. Rational antibody design for undruggable targets using kinetically controlled biomolecular probes. Trkulja CL, Jungholm O, Davidson M, Jardemark K, Marcus MM, Hägglund J, Karlsson A, Karlsson R, Bruton J, Ivarsson N, Srinivasa SP, Cavallin A, Svensson P, Jeffries GDM, Christakopoulou MN, Reymer A, Ashok A, Willman G, Papadia D, Johnsson E, Orwar O. Sci Adv 7 eabe6397 (2021)
  282. Real-Time Observation of Capsaicin-Induced Intracellular Domain Dynamics of TRPV1 Using the Diffracted X-ray Tracking Method. Mio K, Ohkubo T, Sasaki D, Arai T, Sugiura M, Fujimura S, Nozawa S, Sekiguchi H, Kuramochi M, Sasaki YC. Membranes (Basel) 13 708 (2023)
  283. Role of Src kinase in regulating protein kinase C mediated phosphorylation of TRPV1. Robilotto GL, Mohapatra DP, Shepherd AJ, Mickle AD. Eur J Pain 26 1967-1978 (2022)
  284. Sequence and structural conservation reveal fingerprint residues in TRP channels. Cabezas-Bratesco D, Mcgee FA, Colenso CK, Zavala K, Granata D, Carnevale V, Opazo JC, Brauchi SE. Elife 11 e73645 (2022)
  285. Structural basis of TRPV3 inhibition by an antagonist. Fan J, Hu L, Yue Z, Liao D, Guo F, Ke H, Jiang D, Yang Y, Lei X. Nat Chem Biol 19 81-90 (2023)
  286. The asparagine 533 residue in the outer pore loop region of the mouse PKD2L1 channel is essential for its voltage-dependent inactivation. Shimizu T, Higuchi T, Toba T, Ohno C, Fujii T, Nilius B, Sakai H. FEBS Open Bio 7 1392-1401 (2017)
  287. Transient Receptor Potential channels: A Global Bibliometric analysis From 2012 to 2021. Zhu X, Tian C, Zhou Y, Shi J, Yuan G, Zhang L, Jiang Y, Xue W, Du Y, Hu Y. Channels (Austin) 15 624-634 (2021)
  288. Transient receptor potential channel involvement in antinociceptive effect of citral in orofacial acute and chronic pain models. Alves Rodrigues Santos SA, de Barros Mamede Vidal Damasceno M, Alves Magalhães FE, Sessle BJ, Amaro de Oliveira B, Alves Batista FL, Vieira-Neto AE, Rolim Campos A. EXCLI J 21 869-887 (2022)
  289. Two Vanilloid Ligand Bindings Per Channel Are Required to Transduce Capsaicin-Activating Stimuli. Liu TY, Chu Y, Mei HR, Chang D, Chuang HH. Front Mol Neurosci 12 302 (2019)
  290. Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis. Kwon DH, Zhang F, Fedor JG, Suo Y, Lee SY. Nat Commun 13 2874 (2022)
  291. Voltage vs. Ligand I: Structural basis of the intrinsic flexibility of S3 segment and its significance in ion channel activation. Balleza D, Rosas ME, Romero-Romero S. Channels (Austin) 13 455-476 (2019)
  292. t-Butyl pyridine and phenyl C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as potent TRPV1 antagonists. Lee S, Kang DW, Ryu H, Kim C, Ann J, Lee H, Kim E, Hong S, Choi S, Blumberg PM, Frank-Foltyn R, Bahrenberg G, Stockhausen H, Christoph T, Lee J. Bioorg Med Chem 25 2451-2462 (2017)
  293. In vitro exposure to Hymenoptera venom and constituents activates discrete ionotropic pathways in mast cells. Jansen C, Shimoda LMN, Starkus J, Lange I, Rysavy N, Maaetoft-Udsen K, Tobita C, Stokes AJ, Turner H. Channels (Austin) 13 264-286 (2019)
  294. A Comparison Study of the Effect on IBS-D Rats among Ginger-Partitioned Moxibustion, Mild Moxibustion, and Laser Moxibustion. Sun C, Yang X, Xie S, Zhou Z, Yu G, Feng S, Zhao J, Wu J, Ji C. Evid Based Complement Alternat Med 2021 4296216 (2021)
  295. A Structural Overview of TRPML1 and the TRPML Family. Fine M, Li X. Handb Exp Pharmacol 278 181-198 (2023)
  296. A bivalent remipede toxin promotes calcium release via ryanodine receptor activation. Maxwell MJ, Thekkedam C, Lamboley C, Chin YK, Crawford T, Smith JJ, Liu J, Jia X, Vetter I, Laver DR, Launikonis BS, Dulhunty A, Undheim EAB, Mobli M. Nat Commun 14 1036 (2023)
  297. Amelioration of Sensorineural Hearing Loss through Regulation of Trpv1, Cacna1h, and Ngf Gene Expression by a Combination of Cuscutae Semen and Rehmanniae Radix Preparata. Hong BN, Shin SW, Nam YH, Shim JH, Kim NW, Kim MC, Nuankaew W, Kwak JH, Kang TH. Nutrients 15 1773 (2023)
  298. Bibliometric Analysis of Global Research on Transient Receptor Potential Vanilloid 1 in the Field of Pain. Wang S, Wang W, Ye X. J Pain Res 16 1517-1532 (2023)
  299. Bortezomib-induced neuropathy is in part mediated by the sensitization of TRPV1 channels. Sprague JM, Yekkirala AS, Singh B, Tochitsky I, Stephens M, Viramontes O, Ivanis J, Biscola NP, Havton LA, Woolf CJ, Latremoliere A. Commun Biol 6 1228 (2023)
  300. Calcium binding and permeation in TRPV channels: Insights from molecular dynamics simulations. Liu C, Xue L, Song C. J Gen Physiol 155 e202213261 (2023)
  301. Capsaicin and Proton Differently Modulate Activation Kinetics of Mouse Transient Receptor Potential Vanilloid-1 Channel Induced by Depolarization. Takahashi K, Araki K, Miyamoto H, Shirakawa R, Yoshida T, Wakamori M. Front Pharmacol 12 672157 (2021)
  302. Centipede Venom Peptides Acting on Ion Channels. Chu Y, Qiu P, Yu R. Toxins (Basel) 12 E230 (2020)
  303. Cryo-EM structure of mouse TRPML2 in lipid nanodiscs. Song X, Li J, Tian M, Zhu H, Hu X, Zhang Y, Cao Y, Ye H, McCormick PJ, Zeng B, Fu Y, Duan J, Zhang J. J Biol Chem 298 101487 (2022)
  304. Decoding the Effect of Hydrostatic Pressure on TRPV1 Lower-Gate Conformation by Molecular-Dynamics Simulation. Zamri MHB, Ujihara Y, Nakamura M, Mofrad MRK, Sugita S. Int J Mol Sci 23 7366 (2022)
  305. Discovery of a Remarkable Methyl Shift Effect in the Vanilloid Activity of Triterpene Amides. Vitale RM, Avonto C, Del Prete D, Moriello AS, Amodeo P, Appendino G, De Petrocellis L. J Nat Prod 83 3476-3481 (2020)
  306. During capsaicin-induced central sensitization, brush allodynia is associated with baseline warmth sensitivity, whereas mechanical hyperalgesia is associated with painful mechanical sensibility, anxiety and somatization. Meeker TJ, Schmid AC, Liu Y, Keaser ML, Dorsey SG, Seminowicz DA, Greenspan JD. Eur J Pain 25 1971-1993 (2021)
  307. Effect of truncation on TRPM7 channel activity. Xie Z, Abumaria N. Channels (Austin) 17 2200874 (2023)
  308. Estrogen metabolites increase nociceptor hyperactivity in a mouse model of uterine pain. Xie Z, Feng J, Cai T, McCarthy R, Eschbach MD, Wang Y, Zhao Y, Yi Z, Zang K, Yuan Y, Hu X, Li F, Liu Q, Das A, England SK, Hu H. JCI Insight 7 e149107 (2022)
  309. Functional analysis of thermo-sensitive TRPV1 in an aquatic vertebrate, masu salmon (Oncorhynchus masou ishikawae). Yoshimura A, Saito S, Saito CT, Takahashi K, Tominaga M, Ohta T. Biochem Biophys Rep 31 101315 (2022)
  310. Genetically-encoded BRET probes shed light on ligand bias-induced variable ion selectivity in TRPV1 and P2X5/7. Chappe YL, Pierredon S, Joushomme A, Molle P, Garenne A, Canovi A, Barbeau S, Poulletier De Gannes F, Hurtier A, Lagroye I, Ducret T, Quignard JF, Compan V, Percherancier Y. Proc Natl Acad Sci U S A 119 e2205207119 (2022)
  311. Highly Efficient Real-Time TRPV1 Screening Methodology for Effective Drug Candidates. Lim SG, Seo SE, Jo S, Kim KH, Kim L, Kwon OS. ACS Omega 7 36441-36447 (2022)
  312. Human TRPV1 structure and inhibition by the analgesic SB-366791. Neuberger A, Oda M, Nikolaev YA, Nadezhdin KD, Gracheva EO, Bagriantsev SN, Sobolevsky AI. Nat Commun 14 2451 (2023)
  313. Inferring functional units in ion channel pores via relative entropy. Schmidt M, Schroeder I, Bauer D, Thiel G, Hamacher K. Eur Biophys J 50 37-57 (2021)
  314. Microsecond melting and revitrification of cryo samples. Voss JM, Harder OF, Olshin PK, Drabbels M, Lorenz UJ. Struct Dyn 8 054302 (2021)
  315. Molecular mechanism underlying modulation of TRPV1 heat activation by polyols. Nie Y, Li Y, Liu L, Ren S, Tian Y, Yang F. J Biol Chem 297 100806 (2021)
  316. Mutagenesis studies of TRPV1 subunit interfaces informed by genomic variant analysis. Mott TM, Ibarra JS, Kandula N, Senning EN. Biophys J 122 322-332 (2023)
  317. Nanchung and Inactive define pore properties of the native auditory transduction channel in Drosophila. Li B, Li S, Zheng H, Yan Z. Proc Natl Acad Sci U S A 118 e2106459118 (2021)
  318. Novel Alleles of gon-2, a C. elegans Ortholog of Mammalian TRPM6 and TRPM7, Obtained by Genetic Reversion Screens. Lambie EJ, Bruce RD, Zielich J, Yuen SN. PLoS One 10 e0143445 (2015)
  319. Profile of David Julius and Ardem Patapoutian: 2021 Nobel Laureates in Physiology or Medicine. Latorre R, Díaz-Franulic I. Proc Natl Acad Sci U S A 119 e2121015119 (2022)
  320. Purification and Reconstitution of TRPV1 for Spectroscopic Analysis. Sierra-Valdez FJ, Stein RA, Velissety P, Vasquez V, Cordero-Morales JF. J Vis Exp (2018)
  321. Pyrazole C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as potent TRPV1 antagonists. Lee S, Kim C, Ann J, Thorat SA, Kim E, Park J, Choi S, Blumberg PM, Frank-Foltyn R, Bahrenberg G, Stockhausen H, Christoph T, Lee J. Bioorg Med Chem Lett 27 4383-4388 (2017)
  322. Quantitative intrinsic auto-cathodoluminescence can resolve spectral signatures of tissue-isolated collagen extracellular matrix. Zielinski MS, Vardar E, Vythilingam G, Engelhardt EM, Hubbell JA, Frey P, Larsson HM. Commun Biol 2 69 (2019)
  323. Relation between flexibility and intrinsically disorder regions in thermosensitive TRP channels reveal allosteric effects. García-Morales A, Pulido NO, Balleza D. Eur Biophys J (2023)
  324. Responses to transient receptor potential (TRP) channel agonists in Chlamydomonas reinhardtii. Wada M, Kaizuka I, Yoshimura K. Biol Open 9 bio053140 (2020)
  325. Structural insights into TRPV2 activation by small molecules. Pumroy RA, Protopopova AD, Fricke TC, Lange IU, Haug FM, Nguyen PT, Gallo PN, Sousa BB, Bernardes GJL, Yarov-Yarovoy V, Leffler A, Moiseenkova-Bell VY. Nat Commun 13 2334 (2022)
  326. Structural mechanisms of TRPV2 modulation by endogenous and exogenous ligands. Su N, Zhen W, Zhang H, Xu L, Jin Y, Chen X, Zhao C, Wang Q, Wang X, Li S, Wen H, Yang W, Guo J, Yang F. Nat Chem Biol 19 72-80 (2023)
  327. Structure determination of the human TRPV1 ankyrin-repeat domain under nonreducing conditions. Tanaka M, Hayakawa K, Ogawa N, Kurokawa T, Kitanishi K, Ite K, Matsui T, Mori Y, Unno M. Acta Crystallogr F Struct Biol Commun 76 130-137 (2020)
  328. Structure-guided peptide engineering of a positive allosteric modulator targeting the outer pore of TRPV1 for long-lasting analgesia. Zhang H, Lin JJ, Xie YK, Song XZ, Sun JY, Zhang BL, Qi YK, Xu ZZ, Yang F. Nat Commun 14 4 (2023)
  329. TRPV1 and Piezo: the 2021 Nobel Prize in Physiology or Medicine. Cheng Y. IUCrJ 9 4-5 (2022)
  330. TRPV1 in Pain and Itch. Li F, Wang F. Adv Exp Med Biol 1349 249-273 (2021)
  331. Tetrahydropalmatine exerts analgesic effects by promoting apoptosis and inhibiting the activation of glial cells in rats with inflammatory pain. Liu B, Luo M, Meng D, Pan H, Shen H, Shen J, Yao M, Xu L. Mol Pain 17 17448069211042117 (2021)
  332. The capsaicin binding affinity of wildtype and mutant TRPV1 ion channels. Li S, Zheng J. J Biol Chem 299 105268 (2023)
  333. The past and future of transient receptor potential: A scientometric analysis. Jiang N, Pan C, Zhang S, Cheng B, Dong C. Medicine (Baltimore) 101 e30317 (2022)
  334. Two-state model explaining thermodynamic regulation of thermo-gating channels. Zhang XC, Yu Z. Biophys Rep 8 205-211 (2022)
  335. [Structural modeling of selectivity filter in transient receptor pontential melastatin 8 ion channel]. Xu L, Yang F. Zhejiang Da Xue Xue Bao Yi Xue Ban 48 19-24 (2019)


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