3j5m

Electron Microscopy
5.8Å resolution

Cryo-EM structure of the BG505 SOSIP.664 HIV-1 Env trimer with 3 PGV04 Fabs

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
Non-polymer only dodecamer (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Envelope glycoprotein gp160 Chains: A, E, I
Molecule details ›
Chains: A, E, I
Length: 475 amino acids
Theoretical weight: 53.12 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: Q2N0S6 (Residues: 30-504; Coverage: 55%)
Gene name: env
Sequence domains: Envelope glycoprotein GP120
BG505 SOSIP gp41 Chains: B, F, J
Molecule details ›
Chains: B, F, J
Length: 64 amino acids
Theoretical weight: 5.46 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
PGV04 light chain Chains: C, G, K
Molecule details ›
Chains: C, G, K
Length: 208 amino acids
Theoretical weight: 23.07 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
PGV04 heavy chain Chains: D, H, L
Molecule details ›
Chains: D, H, L
Length: 228 amino acids
Theoretical weight: 24.64 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 5.8Å
Relevant EMDB volumes: EMD-5779
Expression system: Homo sapiens