Function and Biology

Pseudo-atomic model of the AKAP18-PKA Complex in a linear conformation derived from electron microscopy

Source organisms:
Biochemical function: protein binding
Biological process: modulation of chemical synaptic transmission
Cellular component: protein-containing complex

EC 2.7.11.11: cAMP-dependent protein kinase

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Systematic name:
ATP:protein phosphotransferase (cAMP-dependent)
Alternative Name(s):
  • PKA
  • PKA C
  • Protein kinase A
  • STK22

Sequence families

Pfam Protein families (Pfam)
PF00027
Domain description: Cyclic nucleotide-binding domain
Occurring in:
  1. cAMP-dependent protein kinase type II-alpha regulatory subunit

PF00069
Domain description: Protein kinase domain
Occurring in:
  1. cAMP-dependent protein kinase catalytic subunit alpha

PF02197
Domain description: Regulatory subunit of type II PKA R-subunit
Occurring in:
  1. cAMP-dependent protein kinase type II-alpha regulatory subunit

PF10469
Domain description: AKAP7 2'5' RNA ligase-like domain
Occurring in:
  1. A-kinase anchor protein 7 isoforms delta and gamma

PF10470
Domain description: PKA-RI-RII subunit binding domain of A-kinase anchor protein
Occurring in:
  1. A-kinase anchor protein 7 isoforms delta and gamma

InterPro InterPro annotations
IPR000595
Domain description: Cyclic nucleotide-binding domain
Occurring in:
  1. cAMP-dependent protein kinase type II-alpha regulatory subunit
IPR018490
Domain description: Cyclic nucleotide-binding-like
Occurring in:
  1. cAMP-dependent protein kinase type II-alpha regulatory subunit
IPR000719
Domain description: Protein kinase domain
Occurring in:
  1. cAMP-dependent protein kinase catalytic subunit alpha
IPR003117
Domain description: cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain
Occurring in:
  1. cAMP-dependent protein kinase type II-alpha regulatory subunit
IPR014710
Domain description: RmlC-like jelly roll fold
Occurring in:
  1. cAMP-dependent protein kinase type II-alpha regulatory subunit
IPR011009
Domain description: Protein kinase-like domain superfamily
Occurring in:
  1. cAMP-dependent protein kinase catalytic subunit alpha
IPR012198
Domain description: cAMP-dependent protein kinase regulatory subunit
Occurring in:
  1. cAMP-dependent protein kinase type II-alpha regulatory subunit
IPR039035
Domain description: cAMP-dependent protein kinase catalytic subunit alpha
Occurring in:
  1. cAMP-dependent protein kinase catalytic subunit alpha
IPR000961
Domain description: AGC-kinase, C-terminal
Occurring in:
  1. cAMP-dependent protein kinase catalytic subunit alpha
IPR009097
Domain description: Cyclic phosphodiesterase
Occurring in:
  1. A-kinase anchor protein 7 isoforms delta and gamma
IPR019511
Domain description: A-kinase anchor protein 7, RI-RII subunit-binding domain
Occurring in:
  1. A-kinase anchor protein 7 isoforms delta and gamma
IPR019510
Domain description: Protein kinase A anchor protein, nuclear localisation signal domain
Occurring in:
  1. A-kinase anchor protein 7 isoforms delta and gamma