› › Function and Biology

Models of E1, E2 and CP of Venezuelan Equine Encephalitis Virus TC-83 strain restrained by a near atomic resolution cryo-EM map

Source organism: Venezuelan equine encephalitis virus (strain TC-83)
Biochemical function: serine-type endopeptidase activity
Biological process: proteolysis
Cellular component: viral capsid

Quick links

EC 3.4.21.90: Togavirin

Reaction catalysed:
Autocatalytic release of the core protein from the N-terminus of the togavirus structural polyprotein by hydrolysis of a -Trp-|-Ser- bond.
Alternative Name(s):
  • NsP2 proteinase
  • Sindbis virus core protein
  • Sindbis virus protease

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF00944
Domain description: Alphavirus core protein
Occurring in:
  1. Capsid protein
The deposited structure of PDB entry 3j0c contains 4 copies of Pfam domain PF00944 (Alphavirus core protein) in Capsid protein. Showing 1 copy in chain C.

PF00943
Domain description: Alphavirus E2 glycoprotein
Occurring in:
  1. Spike glycoprotein E2
The deposited structure of PDB entry 3j0c contains 4 copies of Pfam domain PF00943 (Alphavirus E2 glycoprotein) in Spike glycoprotein E2. Showing 1 copy in chain B.

PF01589
Domain description: Alphavirus E1 glycoprotein
Occurring in:
  1. Spike glycoprotein E1
The deposited structure of PDB entry 3j0c contains 4 copies of Pfam domain PF01589 (Alphavirus E1 glycoprotein) in Spike glycoprotein E1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000930
Domain description: Peptidase S3, togavirin
Occurring in:
  1. Capsid protein
IPR038055
Domain description: Flaviviral glycoprotein E, dimerisation domain
Occurring in:
  1. Spike glycoprotein E1
IPR043504
Domain description: Peptidase S1, PA clan, chymotrypsin-like fold
Occurring in:
  1. Capsid protein
IPR009003
Domain description: Peptidase S1, PA clan
Occurring in:
  1. Capsid protein
IPR042306
Domain description: Alphavirus E2 glycoprotein, domain C
Occurring in:
  1. Spike glycoprotein E2
IPR042305
Domain description: Alphavirus E2 glycoprotein, domain B
Occurring in:
  1. Spike glycoprotein E2
IPR000936
Domain description: Alphavirus E2 glycoprotein
Occurring in:
  1. Spike glycoprotein E2
IPR042304
Domain description: Alphavirus E2 glycoprotein, domain A
Occurring in:
  1. Spike glycoprotein E2
IPR014756
Domain description: Immunoglobulin E-set
Occurring in:
  1. Spike glycoprotein E1
IPR000336
Domain description: Flavivirus/Alphavirus glycoprotein, immunoglobulin-like domain superfamily
Occurring in:
  1. Spike glycoprotein E1
IPR036253
Domain description: Flavivirus glycoprotein, central and dimerisation domain superfamily
Occurring in:
  1. Spike glycoprotein E1
IPR002548
Domain description: Alphavirus E1 glycoprotein
Occurring in:
  1. Spike glycoprotein E1

Quick links