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Ring1B C-terminal domain/RYBP C-terminal domain Complex

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: positive regulation of DNA-templated transcription
Cellular component: ubiquitin ligase complex

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EC 2.3.2.27: RING-type E3 ubiquitin transferase

Reaction catalysed:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Systematic name:
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein]-L-lysine ubiquitin transferase (isopeptide bond-forming; RING-type)
Alternative Name(s):
  • RING E3 ligase
  • Ubiquitin transferase RING E3

GO terms

Biochemical function:
  • not assigned
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF17219
Domain description: Yaf2/RYBP C-terminal binding motif
Occurring in:
  1. RING1 and YY1-binding protein
The deposited structure of PDB entry 3ixs contains 6 copies of Pfam domain PF17219 (Yaf2/RYBP C-terminal binding motif) in RING1 and YY1-binding protein. Showing 1 copy in chain H.

PF16207
Domain description: RAWUL domain RING finger- and WD40-associated ubiquitin-like
Occurring in:
  1. E3 ubiquitin-protein ligase RING2
The deposited structure of PDB entry 3ixs contains 6 copies of Pfam domain PF16207 (RAWUL domain RING finger- and WD40-associated ubiquitin-like) in E3 ubiquitin-protein ligase RING2. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR033774
Domain description: Yaf2/RYBP C-terminal binding motif
Occurring in:
  1. RING1 and YY1-binding protein
IPR039958
Domain description: RING1 and YY1-binding protein/YY1-associated factor 2
Occurring in:
  1. RING1 and YY1-binding protein
IPR032443
Domain description: RAWUL domain
Occurring in:
  1. E3 ubiquitin-protein ligase RING2
IPR043540
Domain description: E3 ubiquitin-protein ligase RING1/RING2
Occurring in:
  1. E3 ubiquitin-protein ligase RING2

Structure domain

CATH CATH domain
3.10.20.90
Class: Alpha Beta
Architecture: Roll
Topology: Ubiquitin-like (UB roll)
Homology: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
Occurring in:
  1. E3 ubiquitin-protein ligase RING2
The deposited structure of PDB entry 3ixs contains 6 copies of CATH domain 3.10.20.90 (Ubiquitin-like (UB roll)) in E3 ubiquitin-protein ligase RING2. Showing 1 copy in chain A.

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