X-ray diffraction
2.24Å resolution

Homocitrate Synthase Lys4


Function and Biology Details

Reaction catalysed:
Acetyl-CoA + H(2)O + 2-oxoglutarate = (R)-2-hydroxybutane-1,2,4-tricarboxylate + CoA

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Homocitrate synthase, mitochondrial Chains: A, B
Molecule details ›
Chains: A, B
Length: 423 amino acids
Theoretical weight: 47.18 KDa
Source organism: Schizosaccharomyces pombe
Expression system: Escherichia coli
  • Canonical: Q9Y823 (Residues: 1-418; Coverage: 100%)
Gene names: SPBC1105.02c, lys4
Sequence domains: HMGL-like
Structure domains: Aldolase class I

Ligands and Environments

2 bound ligands:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P62
Unit cell:
a: 135.995Å b: 135.995Å c: 122.124Å
α: 90° β: 90° γ: 120°
R R work R free
0.193 0.191 0.22
Expression system: Escherichia coli