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Covalent Ubiquitin-Usp5 Complex

Source organism: Homo sapiens
Biochemical function: metal ion binding
Biological process: negative regulation of ubiquitin-dependent protein catabolic process
Cellular component: cytosol

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EC 3.4.19.12: Ubiquitinyl hydrolase 1

Reaction catalysed:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Systematic name:
-
Alternative Name(s):
  • Ubiquitin C-terminal hydrolase
  • Ubiquitin carboxyl-terminal hydrolase
  • Ubiquitin thiolesterase
  • Yeast ubiquitin hydrolase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00627
Domain description: UBA/TS-N domain
Occurring in:
  1. Ubiquitin carboxyl-terminal hydrolase 5
The deposited structure of PDB entry 3ihp contains 4 copies of Pfam domain PF00627 (UBA/TS-N domain) in Ubiquitin carboxyl-terminal hydrolase 5. Showing 2 copies in chain B.

PF00240
Domain description: Ubiquitin family
Occurring in:
  1. Ubiquitin
The deposited structure of PDB entry 3ihp contains 2 copies of Pfam domain PF00240 (Ubiquitin family) in Ubiquitin. Showing 1 copy in chain C.

PF00443
Domain description: Ubiquitin carboxyl-terminal hydrolase
Occurring in:
  1. Ubiquitin carboxyl-terminal hydrolase 5
The deposited structure of PDB entry 3ihp contains 2 copies of Pfam domain PF00443 (Ubiquitin carboxyl-terminal hydrolase) in Ubiquitin carboxyl-terminal hydrolase 5. Showing 1 copy in chain B.

PF02148
Domain description: Zn-finger in ubiquitin-hydrolases and other protein
Occurring in:
  1. Ubiquitin carboxyl-terminal hydrolase 5
The deposited structure of PDB entry 3ihp contains 2 copies of Pfam domain PF02148 (Zn-finger in ubiquitin-hydrolases and other protein) in Ubiquitin carboxyl-terminal hydrolase 5. Showing 1 copy in chain B.

PF17807
Domain description: Variant UBP zinc finger
Occurring in:
  1. Ubiquitin carboxyl-terminal hydrolase 5
The deposited structure of PDB entry 3ihp contains 2 copies of Pfam domain PF17807 (Variant UBP zinc finger) in Ubiquitin carboxyl-terminal hydrolase 5. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR015940
Domain description: Ubiquitin-associated domain
Occurring in:
  1. Ubiquitin carboxyl-terminal hydrolase 5
IPR019956
Domain description: Ubiquitin domain
Occurring in:
  1. Ubiquitin
IPR000626
Domain description: Ubiquitin-like domain
Occurring in:
  1. Ubiquitin
IPR001607
Domain description: Zinc finger, UBP-type
Occurring in:
  1. Ubiquitin carboxyl-terminal hydrolase 5
IPR013083
Domain description: Zinc finger, RING/FYVE/PHD-type
Occurring in:
  1. Ubiquitin carboxyl-terminal hydrolase 5
IPR018200
Domain description: Ubiquitin specific protease, conserved site
Occurring in:
  1. Ubiquitin carboxyl-terminal hydrolase 5
IPR019954
Domain description: Ubiquitin conserved site
Occurring in:
  1. Ubiquitin
IPR029071
Domain description: Ubiquitin-like domain superfamily
Occurring in:
  1. Ubiquitin
IPR009060
Domain description: UBA-like superfamily
Occurring in:
  1. Ubiquitin carboxyl-terminal hydrolase 5
IPR041812
Domain description: Ubiquitin carboxyl-terminal hydrolase 5, UBA1 domain
Occurring in:
  1. Ubiquitin carboxyl-terminal hydrolase 5
IPR028889
Domain description: Ubiquitin specific protease domain
Occurring in:
  1. Ubiquitin carboxyl-terminal hydrolase 5
IPR001394
Domain description: Peptidase C19, ubiquitin carboxyl-terminal hydrolase
Occurring in:
  1. Ubiquitin carboxyl-terminal hydrolase 5
IPR038765
Domain description: Papain-like cysteine peptidase superfamily
Occurring in:
  1. Ubiquitin carboxyl-terminal hydrolase 5
IPR041432
Domain description: Ubiquitinyl hydrolase, variant UBP zinc finger
Occurring in:
  1. Ubiquitin carboxyl-terminal hydrolase 5
IPR016652
Domain description: Ubiquitinyl hydrolase
Occurring in:
  1. Ubiquitin carboxyl-terminal hydrolase 5
IPR008916
Domain description: Retrovirus capsid, C-terminal
Occurring in:
  1. Ubiquitin carboxyl-terminal hydrolase 5

Structure domains

CATH CATH domains
3.30.40.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Herpes Virus-1
Homology: Zinc/RING finger domain, C3HC4 (zinc finger)
Occurring in:
  1. Ubiquitin carboxyl-terminal hydrolase 5
The deposited structure of PDB entry 3ihp contains 4 copies of CATH domain 3.30.40.10 (Herpes Virus-1) in Ubiquitin carboxyl-terminal hydrolase 5. Showing 2 copies in chain B.
1.10.8.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Helicase, Ruva Protein; domain 3
Homology: DNA helicase RuvA subunit, C-terminal domain
Occurring in:
  1. Ubiquitin carboxyl-terminal hydrolase 5
The deposited structure of PDB entry 3ihp contains 4 copies of CATH domain 1.10.8.10 (Helicase, Ruva Protein; domain 3) in Ubiquitin carboxyl-terminal hydrolase 5. Showing 2 copies in chain B.
3.90.70.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Cathepsin B; Chain A
Homology: Cysteine proteinases
Occurring in:
  1. Ubiquitin carboxyl-terminal hydrolase 5
The deposited structure of PDB entry 3ihp contains 2 copies of CATH domain 3.90.70.10 (Cathepsin B; Chain A) in Ubiquitin carboxyl-terminal hydrolase 5. Showing 1 copy in chain B.
3.10.20.90
Class: Alpha Beta
Architecture: Roll
Topology: Ubiquitin-like (UB roll)
Homology: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
Occurring in:
  1. Ubiquitin
The deposited structure of PDB entry 3ihp contains 2 copies of CATH domain 3.10.20.90 (Ubiquitin-like (UB roll)) in Ubiquitin. Showing 1 copy in chain C.

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