3ihj

X-ray diffraction
2.3Å resolution

Human alanine aminotransferase 2 in complex with PLP

Released:
Source organism: Homo sapiens
Entry authors: Wisniewska M, Siponen MI, Arrowsmith CH, Berglund H, Bountra C, Collins R, Edwards AM, Flodin S, Flores A, Graslund S, Hammarstrom M, Johansson A, Johansson I, Karlberg T, Kotenyova T, Kotzsch A, Moche M, Nielsen TK, Nordlund P, Nyman T, Persson C, Roos AK, Schutz P, Svensson L, Thorsell AG, Tresaugues L, Van Den Berg S, Weigelt J, Welin M, Schuler H, Structural Genomics Consortium (SGC)

Function and Biology Details

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alanine aminotransferase 2 Chain: A
Molecule details ›
Chain: A
Length: 498 amino acids
Theoretical weight: 55.41 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8TD30 (Residues: 49-523; Coverage: 91%)
Gene names: AAT2, ALT2, GPT2
Sequence domains: Aminotransferase class I and II
Structure domains:

Ligands and Environments


Cofactor: Ligand PLP 1 x PLP
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P6122
Unit cell:
a: 92.73Å b: 92.73Å c: 262.87Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.192 0.189 0.238
Expression system: Escherichia coli