Function and Biology

Crystal structure of unliganded caspase-7

Source organism: Homo sapiens
Biochemical function: cysteine-type peptidase activity
Biological process: proteolysis
Cellular component: not assigned

EC 3.4.22.60: Caspase-7

Reaction catalysed:
Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Asp-Glu-Val-Asp-|-
Systematic name:
-
Alternative Name(s):
  • Apoptotic protease Mch-3
  • CASP-7
  • CMH-1
  • ICE-LAP3
  • ICE-like apoptotic protease 3
  • Mch3

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

InterPro InterPro annotations
IPR015917
Domain description: Peptidase C14A, caspase catalytic domain
Occurring in:
  1. Caspase-7 subunit p20
  2. Caspase-7 subunit p11
IPR002398
Domain description: Peptidase C14 family
Occurring in:
  1. Caspase-7 subunit p20
  2. Caspase-7 subunit p11
IPR029030
Domain description: Caspase-like domain superfamily
Occurring in:
  1. Caspase-7 subunit p20
  2. Caspase-7 subunit p11
IPR015471
Domain description: Caspase-7
Occurring in:
  1. Caspase-7 subunit p20
  2. Caspase-7 subunit p11

Structure domains

CATH CATH domains
3.30.70.1470
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Alpha-Beta Plaits
Homology: Caspase-like
Occurring in:
  1. Caspase-7 subunit p11
1 copy of CATH domain 3.30.70.1470 (Alpha-Beta Plaits) in Caspase-7 subunit p11 in PDB 3ibf.
3.40.50.1460
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Rossmann fold
Occurring in:
  1. Caspase-7 subunit p20
1 copy of CATH domain 3.40.50.1460 (Rossmann fold) in Caspase-7 subunit p20 in PDB 3ibf.