PDBe 3i7z

X-ray diffraction
2.3Å resolution

Protein Tyrosine Phosphatase 1B - Transition state analog for the first catalytic step

Released:

Function and Biology Details

Reaction catalysed:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
monomeric
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tyrosine-protein phosphatase non-receptor type 1 Chain: A
Molecule details ›
Chain: A
Length: 321 amino acids
Theoretical weight: 37.37 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P18031 (Residues: 1-321; Coverage: 74%)
Gene names: PTP1B, PTPN1
Sequence domains: Protein-tyrosine phosphatase
Structure domains: Protein tyrosine phosphatase superfamily
EGFR receptor fragment Chain: B
Molecule details ›
Chain: B
Length: 6 amino acids
Theoretical weight: 725 Da
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P3121
Unit cell:
a: 88.02Å b: 88.02Å c: 118.62Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.207 0.206 0.233
Expression systems:
  • Escherichia coli
  • Not provided