Structure analysis

Crystal structure of the ATP-gated P2X4 ion channel in the closed, apo state at 3.5 Angstroms (R3)

X-ray diffraction
3.46Å resolution
Source organism: Danio rerio
Assembly composition:
homo trimer (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: homo trimer
Accessible surface area: 45600 Å2
Buried surface area: 13400 Å2
Dissociation area: 5,300 Å2
Dissociation energy (ΔGdiss): 52 kcal/mol
Dissociation entropy (TΔSdiss): 30 kcal/mol
Interface energy (ΔGint): -12 kcal/mol
Symmetry number: 3

Macromolecules

Chains: A, B, C
Length: 356 amino acids
Theoretical weight: 40.19 KDa
Source organism: Danio rerio
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q6NYR1 (Residues: 28-381; Coverage: 91%)
Gene name: p2rx4a
InterPro:
CATH:

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