› 3i1h

X-ray diffraction
2.2Å resolution

Crystal structure of human BFL-1 in complex with BAK BH3 peptide

Released:
DOI: 10.2210/pdb3i1h/pdb
PDB entry 3i1h coloured by chain, front view.
PDB entry 3i1h coloured by chain, side view.
PDB entry 3i1h coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Guan R, Xiao R, Zhao L, Acton T, White E, Gelinas C, Montelione GT, Northeast Structural Genomics Consortium (NESG)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172491 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Bcl-2-related protein A1 Chain: A
Molecule details ›
Chain: A
Length: 161 amino acids
Theoretical weight: 18.66 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q16548 (Residues: 1-151; Coverage: 86%)
Gene names: BCL2A1, BCL2L5, BFL1, GRS, HBPA1
Sequence domains: Apoptosis regulator proteins, Bcl-2 family
Structure domains: Blc2-like
Bcl-2 homologous antagonist/killer Chain: B
Molecule details ›
Chain: B
Length: 16 amino acids
Theoretical weight: 1.73 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q16611 (Residues: 72-87; Coverage: 8%)
Gene names: BAK, BAK1, BCL2L7, CDN1

Ligands and Environments

No bound ligands
1 modified residue:
Ligand CSD 1 x CSD

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4C
Spacegroup: P21
Unit cell:
a: 43.236Å b: 43.145Å c: 46.068Å
α: 90° β: 114.45° γ: 90°
R-values:
R R work R free
0.213 0.213 0.238
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

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