3hz1

X-ray diffraction
2.3Å resolution

Crystal structure of Hsp90 with fragments 37-D04 and 42-C03

Released:
Source organism: Homo sapiens
Entry authors: Barker J, Mather O, Cheng RKY, Palan S, Felicetti B, Whittaker M

Function and Biology Details

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Heat shock protein HSP 90-alpha Chain: A
Molecule details ›
Chain: A
Length: 249 amino acids
Theoretical weight: 27.96 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P07900 (Residues: 9-236; Coverage: 31%)
Gene names: HSP90A, HSP90AA1, HSPC1, HSPCA
Sequence domains: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
Structure domains: Histidine kinase-like ATPase, C-terminal domain

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: I222
Unit cell:
a: 66.952Å b: 91.061Å c: 99.31Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.204 0.201 0.265
Expression system: Escherichia coli