› 3hr3

X-ray diffraction
1.75Å resolution

Interplay of Structure, Hydration and Thermal Stability in Formacetal Modified Oligonucleotides: RNA May Tolerate Hydrophobic Modifications Better than DNA

Released:
DOI: 10.2210/pdb3hr3/pdb
PDB entry 3hr3 coloured by chain, front view.
PDB entry 3hr3 coloured by chain, side view.
PDB entry 3hr3 coloured by chain, top view.
Source organism: synthetic construct
Primary publication:
Interplay of structure, hydration and thermal stability in formacetal modified oligonucleotides: RNA may tolerate nonionic modifications better than DNA.
Kolarovic A, Schweizer E, Greene E, Gironda M, Pallan PS, Egli M, Rozners E
J Am Chem Soc 131 14932-7 (2009)
PMID: 19824732

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-116376 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
5'-D(*GP*CP*GP*(US4)P*(OMU))P*AP*CP*GP*C)-3' Chain: A
Molecule details ›
Chain: A
Length: 9 nucleotides
Theoretical weight: 3.01 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
1 modified residue:
Ligand OMU 1 x OMU

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: P41212
Unit cell:
a: 33.199Å b: 33.199Å c: 68.508Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.231 0.228 0.282
Expression system: Not provided

Quick links

Citations

1 review citation

Primitive genetic polymers.
Engelhart et al. (2010)
8 other articles

2 mentions without citation

The many twists and turns of DNA: template, telomere, tool, and target.
Egli et al. (2010)
1 more