PDBe 3hpn

X-ray diffraction
2.52Å resolution

Ligand recognition by A-class EPH receptors: crystal structures of the EPHA2 ligand-binding domain and the EPHA2/EPHRIN-A1 complex


Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Entry contents:
1 distinct polypeptide molecule
Ephrin type-A receptor 2 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 174 amino acids
Theoretical weight: 19.91 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
  • Canonical: P29317 (Residues: 28-201; Coverage: 18%)
Gene names: ECK, EPHA2
Sequence domains: Ephrin receptor ligand binding domain
Structure domains: Galactose-binding domain-like

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P1
Unit cell:
a: 41.271Å b: 91.187Å c: 91.132Å
α: 117.14° β: 97.27° γ: 100.79°
R R work R free
0.236 0.232 0.307
Expression system: Homo sapiens