3ho5

X-ray diffraction
3.01Å resolution

Crystal structure of Hedgehog-interacting protein (HHIP) and Sonic hedgehog (SHH) complex

Released:

Function and Biology Details

Structure analysis Details

Assemblies composition:
monomeric
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-172299 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Hedgehog-interacting protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 481 amino acids
Theoretical weight: 54.09 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q96QV1 (Residues: 193-667; Coverage: 70%)
Gene names: HHIP, HIP, UNQ5825/PRO19644
Sequence domains:
Structure domains: Laminin
Sonic hedgehog protein N-product Chain: H
Molecule details ›
Chain: H
Length: 169 amino acids
Theoretical weight: 19.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15465 (Residues: 29-197; Coverage: 39%)
Gene name: SHH
Sequence domains: Hedgehog amino-terminal signalling domain
Structure domains: Muramoyl-pentapeptide Carboxypeptidase; domain 2

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: P3121
Unit cell:
a: 101.618Å b: 101.618Å c: 302.83Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.234 0.231 0.287
Expression systems:
  • Trichoplusia ni
  • Escherichia coli