EC 1.17.4.1: Ribonucleoside-diphosphate reductase
Reaction catalysed:
2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H(2)O = ribonucleoside diphosphate + thioredoxin
Systematic name:
2'-deoxyribonucleoside-diphosphate:thioredoxin-disulfide 2'-oxidoreductase
Alternative Name(s):
- 2'-deoxyribonucleoside-diphosphate:oxidized-thioredoxin 2'-oxidoreductase
- ADP reductase
- CDP reductase
- NrdB (gene name)
- NrdF (gene name)
- NrdJ (gene name)
- Nucleoside diphosphate reductase
- RR
- Ribonucleoside 5'-diphosphate reductase
- Ribonucleoside diphosphate reductase
- Ribonucleotide diphosphate reductase
- Ribonucleotide reductase
- UDP reductase
GO terms
Biochemical function:
- disordered domain specific binding
- ribonucleoside-diphosphate reductase activity
- identical protein binding
- purine nucleotide binding
- oxidoreductase activity
- ATP binding
- protein binding
- ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
- catalytic activity
- nucleotide binding
Biological process:
- positive regulation of G1/S transition of mitotic cell cycle
- positive regulation of G0 to G1 transition
- retina development in camera-type eye
- protein heterotetramerization
- cell proliferation in forebrain
- positive regulation of G2/M transition of mitotic cell cycle
- response to ionizing radiation
- 2'-deoxyribonucleotide biosynthetic process
- deoxyribonucleotide biosynthetic process
- ribonucleoside diphosphate metabolic process
- male gonad development
- metabolic process
- DNA repair
- mitochondrial DNA replication
- DNA replication
- pyrimidine nucleobase metabolic process
- DNA synthesis involved in DNA repair
Cellular component:
Sequence families
Protein families (Pfam)
InterPro annotations
IPR013346
Domain description:
Ribonucleotide reductase, class I, alpha subunit, C-terminal
Occurring in:
Occurring in: