› 3hnb

X-ray diffraction
1.15Å resolution

Factor VIII Trp2313-His2315 segment is involved in membrane binding as shown by crystal structure of complex between factor VIII C2 domain and an inhibitor

Released:
DOI: 10.2210/pdb3hnb/pdb
PDB 3hnb coloured by chain and viewed from the front.
PDB 3hnb coloured by chain and viewed from the side.
PDB 3hnb coloured by chain and viewed from the top.
Source organism: Homo sapiens
Primary publication:
Trp2313-His2315 of factor VIII C2 domain is involved in membrane binding: structure of a complex between the C2 domain and an inhibitor of membrane binding.
Liu Z, Lin L, Yuan C, Nicolaes GA, Chen L, Meehan EJ, Furie B, Furie B, Huang M
J. Biol. Chem. 285 8824-9 (2010)
PMID: 20089867

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Factor VIIIa light chain Chain: M
Molecule details ›
Chain: M
Length: 159 amino acids
Theoretical weight: 18.03 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P00451 (Residues: 2189-2347; Coverage: 7%)
Gene names: F8, F8C
Sequence domains: F5/8 type C domain
Structure domains: Galactose-binding domain-like

Ligands and Environments

1 bound ligand:
Ligand 768 1 x 768
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P212121
Unit cell:
a: 42.054Å b: 55.775Å c: 67.971Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.208 0.185 0.22
Expression system: Komagataella pastoris

Quick links

Citations

4 review citations

The role of phosphatidylserine on the membrane in immunity and blood coagulation.
Wang et al. (2022)
3 more

4 mentions without citation

Trp2313-His2315 of factor VIII C2 domain is involved in membrane binding: structure of a complex between the C2 domain and an inhibitor of membrane binding.
Liu et al. (2010)
3 more