3hmi

X-ray diffraction
1.65Å resolution

The crystal structure of human ABL2 in complex with 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE

Released:
Source organism: Homo sapiens
Entry authors: Ugochukwu E, Salah E, Barr A, Mahajan P, Shrestha B, Savitsky P, Chaikuad A, Allerston C, von Delft F, Bountra C, Arrowsmith CH, Weigelt J, Edwards A, Knapp S, Structural Genomics Consortium (SGC)

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase ABL2 Chain: A
Molecule details ›
Chain: A
Length: 292 amino acids
Theoretical weight: 33.54 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P42684 (Residues: 279-546; Coverage: 23%)
Gene names: ABL2, ABLL, ARG
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: C2
Unit cell:
a: 165.92Å b: 39.8Å c: 43.13Å
α: 90° β: 95.69° γ: 90°
R-values:
R R work R free
0.19 0.188 0.234
Expression system: Trichoplusia ni