3hkl

X-ray diffraction
2.1Å resolution

Crystal Structure of the Frizzled-like Cysteine-rich Domain of MuSK

Released:

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Muscle, skeletal receptor tyrosine protein kinase Chains: A, B
Molecule details ›
Chains: A, B
Length: 197 amino acids
Theoretical weight: 21.89 KDa
Source organism: Rattus norvegicus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q62838 (Residues: 313-494; Coverage: 22%)
Gene name: Musk
Sequence domains: Fz domain
Structure domains: Frizzled cysteine-rich domain

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4C
Spacegroup: P21
Unit cell:
a: 65.592Å b: 44.422Å c: 69.53Å
α: 90° β: 108.27° γ: 90°
R-values:
R R work R free
0.228 0.226 0.264
Expression system: Spodoptera frugiperda