X-ray diffraction
2.8Å resolution

Crystal structure of p110alpha H1047R mutant in complex with niSH2 of p85alpha and the drug wortmannin


Function and Biology Details

Structure analysis Details

Assembly composition:
Non-polymer only dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Chain: A
Phosphatidylinositol 3-kinase regulatory subunit alpha Chain: B
Molecule details ›
Chain: B
Length: 373 amino acids
Theoretical weight: 44.26 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: P27986 (Residues: 322-694; Coverage: 52%)
Gene names: GRB1, PIK3R1
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 31-ID
Spacegroup: P212121
Unit cell:
a: 115.312Å b: 121.453Å c: 152.494Å
α: 90° β: 90° γ: 90°
R R work R free
0.243 0.223 0.307
Expression system: Spodoptera frugiperda