X-ray diffraction
1.6Å resolution

Crystal Structure of Cathepsin B from T. brucei in complex with CA074


Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Pept_C1 domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 325 amino acids
Theoretical weight: 35.92 KDa
Source organism: Trypanosoma brucei
Expression system: Komagataella pastoris
  • Canonical: Q6R7Z5 (Residues: 23-340; Coverage: 100%)
Sequence domains: Papain family cysteine protease
Structure domains: Cysteine proteinases

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL7-1
Spacegroup: P21
Unit cell:
a: 53.881Å b: 75.134Å c: 75.9Å
α: 90° β: 105.02° γ: 90°
R R work R free
0.148 0.147 0.178
Expression system: Komagataella pastoris