› 3hh7

X-ray diffraction
1.55Å resolution

Structural and Functional Characterization of a Novel Homodimeric Three-finger Neurotoxin from the Venom of Ophiophagus hannah (King Cobra)

Released:
DOI: 10.2210/pdb3hh7/pdb
PDB entry 3hh7 coloured by chain, front view.
PDB entry 3hh7 coloured by chain, side view.
PDB entry 3hh7 coloured by chain, top view.
Source organism: Ophiophagus hannah
Primary publication:
Structural and functional characterization of a novel homodimeric three-finger neurotoxin from the venom of Ophiophagus hannah (king cobra).
Roy A, Zhou X, Chong MZ, D'hoedt D, Foo CS, Rajagopalan N, Nirthanan S, Bertrand D, Sivaraman J, Kini RM
J Biol Chem 285 8302-15 (2010)
PMID: 20071329

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-108760 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Haditoxin Chains: A, B
Molecule details ›
Chains: A, B
Length: 65 amino acids
Theoretical weight: 7.55 KDa
Source organism: Ophiophagus hannah
UniProt:
  • Canonical: A8N286 (Residues: 22-86; Coverage: 100%)
Structure domains: CD59

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BRUKER AXS MICROSTAR-H
Spacegroup: P21
Unit cell:
a: 37.265Å b: 41.292Å c: 40.978Å
α: 90° β: 106.4° γ: 90°
R-values:
R R work R free
0.196 0.194 0.225

Quick links

Citations

6 review citations

Three-finger snake neurotoxins and Ly6 proteins targeting nicotinic acetylcholine receptors: pharmacological tools and endogenous modulators.
Tsetlin VI. (2015)
5 more

8 mentions without citation

Studies on sea snake venom.
Tamiya et al. (2011)
7 more