› 3hcv

X-ray diffraction
1.95Å resolution

Crystal structure of HLA-B*2709 complexed with the double citrullinated vasoactive intestinal peptide type 1 receptor (VIPR) peptide (residues 400-408)

Released:
DOI: 10.2210/pdb3hcv/pdb
PDB 3hcv coloured by chain and viewed from the front.
PDB 3hcv coloured by chain and viewed from the side.
PDB 3hcv coloured by chain and viewed from the top.
Source organism: Homo sapiens
Entry authors: Beltrami A, Gabdulkhakov A, Rossmann M, Ziegler A, Uchanska-Ziegler B, Saenger W

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
HLA class I histocompatibility antigen, B alpha chain Chain: A
Molecule details ›
Chain: A
Length: 276 amino acids
Theoretical weight: 31.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01889 (Residues: 25-300; Coverage: 82%)
Gene names: HLA-B, HLAB
Sequence domains:
Structure domains:
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Vasoactive intestinal polypeptide receptor 1 Chain: C
Molecule details ›
Chain: C
Length: 9 amino acids
Theoretical weight: 1.4 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P32241 (Residues: 400-408; Coverage: 2%)
Gene name: VIPR1

Ligands and Environments

No bound ligands
1 modified residue:
Ligand CIR 2 x CIR

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P21
Unit cell:
a: 51.176Å b: 82.428Å c: 67.017Å
α: 90° β: 110.15° γ: 90°
R-values:
R R work R free
0.227 0.199 0.245
Expression systems:
  • Escherichia coli
  • Not provided

Quick links