EC 2.1.1.45: Thymidylate synthase
Reaction catalysed:
5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP
Systematic name:
5,10-methylenetetrahydrofolate:dUMP C-methyltransferase
Alternative Name(s):
- Methylenetetrahydrofolate:dUMP C-methyltransferase
- TMP synthetase
- Thymidylate synthetase
- dTMP synthase
GO terms
Biochemical function:
- sequence-specific mRNA binding
- heterocyclic compound binding
- protein homodimerization activity
- transferase activity, transferring one-carbon groups
- transferase activity
- methyltransferase activity
- folic acid binding
- thymidylate synthase activity
- dihydrofolate reductase activity
- mRNA binding
- mRNA regulatory element binding translation repressor activity
Biological process:
- liver regeneration
- DNA biosynthetic process
- intestinal epithelial cell maturation
- response to folic acid
- response to glucocorticoid
- cartilage development
- developmental growth
- response to organophosphorus
- tetrahydrofolate metabolic process
- response to ethanol
- tetrahydrofolate interconversion
- response to cytokine
- response to vitamin A
- response to progesterone
- methylation
- uracil metabolic process
- negative regulation of translation
- response to organic cyclic compound
- response to toxic substance
- response to xenobiotic stimulus
- nucleotide biosynthetic process
- circadian rhythm
- regulation of translation
- dTTP biosynthetic process
- dTMP biosynthetic process
- pyrimidine nucleobase metabolic process
Protein family (Pfam)
InterPro annotations
CATH domain