› 3h95

X-ray diffraction
1.7Å resolution

Crystal structure of the NUDIX domain of NUDT6

Released:
DOI: 10.2210/pdb3h95/pdb
PDB entry 3h95 coloured by chain, front view.
PDB entry 3h95 coloured by chain, side view.
PDB entry 3h95 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Tresaugues L, Moche M, Arrowsmith CH, Berglund H, Bountra C, Collins R, Edwards AM, Flodin S, Flores A, Graslund S, Hammarstrom M, Johansson A, Johansson I, Karlberg T, Kotyenova T, Kotzch A, Nielsen TK, Nyman T, Persson C, Sagemark J, Schueler H, Schutz P, Siponen MI, Svensson L, Thorsell AG, Van Den Berg S, Weigelt J, Welin M, Wisniewska M, Nordlund P, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156796 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nucleoside diphosphate-linked moiety X motif 6 Chain: A
Molecule details ›
Chain: A
Length: 199 amino acids
Theoretical weight: 22.99 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P53370 (Residues: 141-316; Coverage: 56%)
Gene names: FGF2AS, NUDT6
Sequence domains: NUDIX domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand FLC 1 x FLC
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P41212
Unit cell:
a: 54.53Å b: 54.53Å c: 133.71Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.196 0.194 0.221
Expression system: Escherichia coli

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