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Activator-Bound Structure of Human Pyruvate Kinase M2

X-ray diffraction
2Å resolution
PDB entry 3h6o coloured by chain, front view.
PDB entry 3h6o coloured by chain, side view.
PDB entry 3h6o coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Pyruvate kinase PKM
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Multimeric state: homo tetramer
Accessible surface area: 67377.17 Å2
Buried surface area: 19358.68 Å2
Dissociation area: 2,944.32 Å2
Dissociation energy (ΔGdiss): 29.82 kcal/mol
Dissociation entropy (TΔSdiss): 16.15 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-146985

Macromolecules

Pyruvate kinase PKM
Chains: A, B, C, D
Length: 550 amino acids
Theoretical weight: 60.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P14618 (Residues: 1-531; Coverage: 100%)
Gene names: OIP3, PK2, PK3, PKM, PKM2
Pfam:
InterPro:
CATH:
Pyruvate kinase PKM in PDB entry 3h6o, assembly 1, front view.
Pyruvate kinase PKM in PDB entry 3h6o, assembly 1, side view.
Pyruvate kinase PKM in PDB entry 3h6o, assembly 1, top view.
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