› 3h6h

X-ray diffraction
2.9Å resolution

Crystal structure of the GluR6 amino terminal domain dimer assembly MPD form

Released:
DOI: 10.2210/pdb3h6h/pdb
PDB 3h6h coloured by chain and viewed from the front.
PDB 3h6h coloured by chain and viewed from the side.
PDB 3h6h coloured by chain and viewed from the top.
Source organism: Rattus norvegicus
Primary publication:
The N-terminal domain of GluR6-subtype glutamate receptor ion channels.
Kumar J, Schuck P, Jin R, Mayer ML
Nat. Struct. Mol. Biol. 16 631-8 (2009)
PMID: 19465914

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor ionotropic, kainate 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 395 amino acids
Theoretical weight: 44.75 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
  • Canonical: P42260 (Residues: 32-420; Coverage: 44%)
Gene names: Glur6, Grik2
Sequence domains: Receptor family ligand binding region
Structure domains: Rossmann fold

Ligands and Environments

2 bound ligands:
Ligand NAG 8 x NAG
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P61
Unit cell:
a: 177.253Å b: 177.253Å c: 81.173Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.213 0.21 0.254
Expression system: Homo sapiens

Quick links

Citations

18 review citations

Evolution of glutamatergic signaling and synapses.
Moroz et al. (2021)
17 more

5 mentions without citation

Structure, Dynamics, and Allosteric Potential of Ionotropic Glutamate Receptor N-Terminal Domains.
Krieger et al. (2015)
4 more