X-ray diffraction
2Å resolution

Crystal structure of PYK2 in complex with Sulfoximine-substituted trifluoromethylpyrimidine analog


Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Protein-tyrosine kinase 2-beta Chain: A
Molecule details ›
Chain: A
Length: 277 amino acids
Theoretical weight: 32.19 KDa
Source organism: Homo sapiens
Expression system: unidentified baculovirus
  • Canonical: Q14289 (Residues: 416-692; Coverage: 28%)
Gene names: FAK2, PTK2B, PYK2, RAFTK
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P21
Unit cell:
a: 37.281Å b: 92.83Å c: 42.843Å
α: 90° β: 92.64° γ: 90°
R R work R free
0.225 0.222 0.273
Expression system: unidentified baculovirus