3h13

X-ray diffraction
2.2Å resolution

c-FLIPL protease-like domain

Released:
Source organism: Homo sapiens
Primary publication:
Mechanism of procaspase-8 activation by c-FLIPL.
Proc. Natl. Acad. Sci. U.S.A. 106 8169-74 (2009)
PMID: 19416807

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CASP8 and FADD-like apoptosis regulator subunit p43 Chain: A
Molecule details ›
Chain: A
Length: 272 amino acids
Theoretical weight: 31.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O15519 (Residues: 209-480; Coverage: 57%)
Gene names: CASH, CASP8AP1, CFLAR, CLARP, MRIT
Sequence domains: Caspase domain
Structure domains: Rossmann fold

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P3121
Unit cell:
a: 101.94Å b: 101.94Å c: 61.36Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.187 0.187 0.22
Expression system: Escherichia coli