› 3h00

X-ray diffraction
2.2Å resolution

Structure of the C-terminal Domain of a Putative HIV-1 gp41 Fusion Intermediate

Released:
DOI: 10.2210/pdb3h00/pdb
PDB entry 3h00 coloured by chain, front view.
PDB entry 3h00 coloured by chain, side view.
PDB entry 3h00 coloured by chain, top view.
Source organism: Human immunodeficiency virus type 1 lw12.3 isolate
Primary publication:
Role of a putative gp41 dimerization domain in human immunodeficiency virus type 1 membrane fusion.
Liu J, Deng Y, Li Q, Dey AK, Moore JP, Lu M
J Virol 84 201-9 (2010)
PMID: 19846514

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180642 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transmembrane protein gp41 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 39 amino acids
Theoretical weight: 4.8 KDa
Source organism: Human immunodeficiency virus type 1 lw12.3 isolate
Expression system: Escherichia coli
UniProt:
  • Canonical: Q70626 (Residues: 636-674; Coverage: 5%)
Gene name: env

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: C2
Unit cell:
a: 120.764Å b: 47.499Å c: 74.824Å
α: 90° β: 128.32° γ: 90°
R-values:
R R work R free
0.214 0.212 0.255
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Biochemistry and biophysics of HIV-1 gp41 - membrane interactions and implications for HIV-1 envelope protein mediated viral-cell fusion and fusion inhibitor design.
Cai et al. (2011)
11 other articles

6 mentions without citation

Molecular Investigation of SARS-CoV-2 Proteins and Their Interactions with Antiviral Drugs.
Calligari et al. (2020)
5 more