3gxu

X-ray diffraction
2.5Å resolution

Crystal structure of Eph receptor and ephrin complex

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Ephrin type-A receptor 4 Chain: A
Molecule details ›
Chain: A
Length: 175 amino acids
Theoretical weight: 20.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P54764 (Residues: 29-203; Coverage: 18%)
Gene names: EPHA4, HEK8, SEK, TYRO1
Structure domains: Galactose-binding domain-like
Ephrin-B2 Chain: B
Molecule details ›
Chain: B
Length: 143 amino acids
Theoretical weight: 16.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P52799 (Residues: 27-169; Coverage: 46%)
Gene names: EFNB2, EPLG5, HTKL, LERK5
Sequence domains: Ephrin
Structure domains: Cupredoxins - blue copper proteins

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BRUKER AXS MICROSTAR-H
Spacegroup: P21
Unit cell:
a: 54.651Å b: 48.711Å c: 64.469Å
α: 90° β: 110.43° γ: 90°
R-values:
R R work R free
0.33 0.182 0.273
Expression system: Escherichia coli