› 3gwx

X-ray diffraction
2.4Å resolution

MOLECULAR RECOGNITION OF FATTY ACIDS BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS

Released:
DOI: 10.2210/pdb3gwx/pdb
PDB 3gwx coloured by chain and viewed from the front.
PDB 3gwx coloured by chain and viewed from the side.
PDB 3gwx coloured by chain and viewed from the top.
Source organism: Homo sapiens
Primary publication:
Molecular recognition of fatty acids by peroxisome proliferator-activated receptors.
Xu HE, Lambert MH, Montana VG, Parks DJ, Blanchard SG, Brown PJ, Sternbach DD, Lehmann JM, Wisely GB, Willson TM, Kliewer SA, Milburn MV
Mol. Cell 3 397-403 (1999)
PMID: 10198642

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxisome proliferator-activated receptor delta Chains: A, B
Molecule details ›
Chains: A, B
Length: 271 amino acids
Theoretical weight: 31.02 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q03181 (Residues: 171-441; Coverage: 62%)
Gene names: NR1C2, PPARB, PPARD
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand EPA 2 x EPA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P21
Unit cell:
a: 39.379Å b: 95.543Å c: 96.181Å
α: 90° β: 97.89° γ: 90°
R-values:
R R work R free
0.242 0.242 0.301
Expression system: Escherichia coli

Quick links

Citations

194 review citations

Metabolic factors contribute to T-cell inhibition in the ovarian cancer ascites.
Gong et al. (2020)
193 more

8 mentions without citation

Activation of PPARĪ“: from computer modelling to biological effects.
Kahremany et al. (2015)
7 more