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Lovastatin polyketide enoyl reductase (LovC) mutant K54S with bound NADP

Source organism: Aspergillus terreus
Biochemical function: NADPH binding
Biological process: lovastatin biosynthetic process
Cellular component: not assigned

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EC 2.3.1.161: Lovastatin nonaketide synthase

Reaction catalysed:
9 malonyl-CoA + 11 NADPH + S-adenosyl-L-methionine + holo-[lovastatin nonaketide synthase] = dihydromonacolin L-[lovastatin nonaketide synthase] + 9 CoA + 9 CO(2) + 11 NADP(+) + S-adenosyl-L-homocysteine + 6 H(2)O
Systematic name:
Acyl-CoA:malonyl-CoA C-acyltransferase (dihydromonacolin L acid-forming)
Alternative Name(s):
  • Acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing, thioester-hydrolyzing)
  • LNKS
  • LovB
  • LovC

GO terms

Sequence family

Pfam Protein family (Pfam)
PF08240
Domain description: Alcohol dehydrogenase GroES-like domain
Occurring in:
  1. Lovastatin nonaketide synthase, enoyl reductase component lovC
The deposited structure of PDB entry 3gqv contains 1 copy of Pfam domain PF08240 (Alcohol dehydrogenase GroES-like domain) in Lovastatin nonaketide synthase, enoyl reductase component lovC. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR047122
Domain description: Trans-enoyl reductase-like
Occurring in:
  1. Lovastatin nonaketide synthase, enoyl reductase component lovC
IPR036291
Domain description: NAD(P)-binding domain superfamily
Occurring in:
  1. Lovastatin nonaketide synthase, enoyl reductase component lovC
IPR013154
Domain description: Alcohol dehydrogenase-like, N-terminal
Occurring in:
  1. Lovastatin nonaketide synthase, enoyl reductase component lovC
IPR020843
Domain description: Polyketide synthase, enoylreductase domain
Occurring in:
  1. Lovastatin nonaketide synthase, enoyl reductase component lovC
IPR011032
Domain description: GroES-like superfamily
Occurring in:
  1. Lovastatin nonaketide synthase, enoyl reductase component lovC

Structure domains

CATH CATH domains
3.90.180.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Quinone Oxidoreductase; Chain A, domain 1
Homology: Medium-chain alcohol dehydrogenases, catalytic domain
Occurring in:
  1. Lovastatin nonaketide synthase, enoyl reductase component lovC
The deposited structure of PDB entry 3gqv contains 1 copy of CATH domain 3.90.180.10 (Quinone Oxidoreductase; Chain A, domain 1) in Lovastatin nonaketide synthase, enoyl reductase component lovC. Showing 1 copy in chain A.
3.40.50.720
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: NAD(P)-binding Rossmann-like Domain
Occurring in:
  1. Lovastatin nonaketide synthase, enoyl reductase component lovC
The deposited structure of PDB entry 3gqv contains 1 copy of CATH domain 3.40.50.720 (Rossmann fold) in Lovastatin nonaketide synthase, enoyl reductase component lovC. Showing 1 copy in chain A.

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