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Crystal Structure of activated receptor tyrosine kinase in complex with substrates

X-ray diffraction
2.5Å resolution
PDB entry 3gqi coloured by chain, front view.
PDB entry 3gqi coloured by chain, side view.
PDB entry 3gqi coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 and Fibroblast growth factor receptor 1
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Multimeric state: hetero dimer
Accessible surface area: 26461.61 Å2
Buried surface area: 3526.48 Å2
Dissociation area: 1,077.38 Å2
Dissociation energy (ΔGdiss): 6.45 kcal/mol
Dissociation entropy (TΔSdiss): 13.12 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-145420

Macromolecules

Fibroblast growth factor receptor 1
Chain: A
Length: 326 amino acids
Theoretical weight: 37.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P11362 (Residues: 458-774; Coverage: 40%)
Gene names: BFGFR, CEK, FGFBR, FGFR1, FLG, FLT2, HBGFR
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:
CATH:
Fibroblast growth factor receptor 1 in PDB entry 3gqi, assembly 1, front view.
Fibroblast growth factor receptor 1 in PDB entry 3gqi, assembly 1, side view.
Fibroblast growth factor receptor 1 in PDB entry 3gqi, assembly 1, top view.
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1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
Chain: B
Length: 226 amino acids
Theoretical weight: 26.32 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P10686 (Residues: 545-770; Coverage: 18%)
Gene name: Plcg1
Pfam: SH2 domain
InterPro:
CATH: SH2 domain
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 in PDB entry 3gqi, assembly 1, front view.
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 in PDB entry 3gqi, assembly 1, side view.
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 in PDB entry 3gqi, assembly 1, top view.
Molecule details ›

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