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Human cytochrome P450 2E1 in complex with omega-imidazolyl-decanoic acid

X-ray diffraction
2.7Å resolution
PDB entry 3gph coloured by chain, front view.
PDB entry 3gph coloured by chain, side view.
PDB entry 3gph coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Cytochrome P450 2E1
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Multimeric state: monomeric
Accessible surface area: 19829.23 Å2
Buried surface area: 1196.08 Å2
Dissociation area: 598.04 Å2
Dissociation energy (ΔGdiss): 19.43 kcal/mol
Dissociation entropy (TΔSdiss): 5.87 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-138579
Assembly 2
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Assembly Name: Cytochrome P450 2E1
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Multimeric state: monomeric
Accessible surface area: 19862.14 Å2
Buried surface area: 1211.44 Å2
Dissociation area: 605.72 Å2
Dissociation energy (ΔGdiss): 21.04 kcal/mol
Dissociation entropy (TΔSdiss): 5.87 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-138579

Macromolecules

Cytochrome P450 2E1
Chains: A, B
Length: 476 amino acids
Theoretical weight: 55.06 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05181 (Residues: 32-493; Coverage: 94%)
Gene names: CYP2E, CYP2E1
Pfam: Cytochrome P450
InterPro:
CATH: Cytochrome P450
Cytochrome P450 2E1 in PDB entry 3gph, assembly 1, front view.
Cytochrome P450 2E1 in PDB entry 3gph, assembly 1, side view.
Cytochrome P450 2E1 in PDB entry 3gph, assembly 1, top view.
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