X-ray diffraction
1.9Å resolution

Crystal Structure of Human Mitogen Activated Protein Kinase 11 (p38 beta) in complex with Nilotinib

Source organism: Homo sapiens
Entry authors: Filippakopoulos P, Barr A, Fedorov O, Keates T, Soundararajan M, Elkins J, Salah E, Burgess-Brown N, Ugochukwu E, Pike ACW, Muniz J, Roos A, Chaikuad A, von Delft F, Arrowsmith CH, Edwards AM, Weigelt J, Bountra C, Knapp S, Structural Genomics Consortium (SGC)

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Mitogen-activated protein kinase 11 Chain: A
Molecule details ›
Chain: A
Length: 348 amino acids
Theoretical weight: 39.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q15759 (Residues: 5-350; Coverage: 95%)
Gene names: MAPK11, PRKM11, SAPK2, SAPK2B
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P212121
Unit cell:
a: 38.94Å b: 60.08Å c: 148.55Å
α: 90° β: 90° γ: 90°
R R work R free
0.181 0.178 0.232
Expression system: Escherichia coli